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Hydrogels for Cartilage Tissue Engineering

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Biomedical Applications of Hydrogels Handbook

Abstract

Tissue engineering is an emerging field of regenerative medicine that holds promise for the restoration of tissues and organs affected by chronic diseases, age-linked degeneration, congenital deformity, and trauma. Tissue engineering consists of building tissue and organs using cells grown on natural or artificial biomaterials outside the body. Recent efforts in bone and cartilage tissue regeneration have turned to tissue engineering, which have shown the proof of concept in clinical situations. Articular cartilage is composed of 70–80% of water retained in the form of a stable macromolecular gels. The extracellular matrix (ECM) and chondrocytes represent 20–30% of the articular cartilage. The lack of vascularization of the articular cartilage, however, prevents the development of an inflammatory response; this severely limits spontaneous repair. Currently, research is being directed to cell therapy associated with specific scaffold-like hydrogels. Articular cartilage, in particular, is considered to be a good candidate for tissue engineering, because it requires less metabolic involvement due to lower cellularity and avascular matrix. Cartilage organization and pathology have been highlighted here with respect to scaffold strategies using synthetic hydrogels as biomimetic extracellular matrices for tissue engineering.

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Authors and Affiliations

  1. Laboratoire d’ingénierie Ostéo-articulaire et dentaire, LIOAD, Inserm, UMR_S 791, 1 place A. Ricordeau, Nantes, F-44042, France

    Pierre Weiss, Ahmed Fatimi, Jerome Guicheux & Claire Vinatier

  2. Laboratoire d’ingénierie Ostéo-articulaire et dentaire, LIOAD Faculté de chirurgie dentaire, IFR 26, Université de Nantes, 1 place A. Ricordeau, Nantes, F-44042, France

    Pierre Weiss, Ahmed Fatimi, Jerome Guicheux & Claire Vinatier

  3. GRAFTYS SA, 415 rue Claude Ledoux, 13854, Aix en Provence, France

    Claire Vinatier

Authors
  1. Pierre Weiss
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  2. Ahmed Fatimi
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  3. Jerome Guicheux
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  4. Claire Vinatier
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Corresponding author

Correspondence to Pierre Weiss .

Editor information

Editors and Affiliations

  1. Virginia Commonwealth University, Richmond, 23284, Virgin Islands, USA

    Raphael M. Ottenbrite

  2. Dept. Biomedical Engineering, Purdue University, West Lafayette, 47907-1296, Indiana, USA

    Kinam Park

  3. Tokyo Women's Medical College, Kawada-cho Ichigaya 8-1, Tokyo, 162-8666, Japan

    Teruo Okano

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© 2010 Springer Science+Business Media, LLC

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Weiss, P., Fatimi, A., Guicheux, J., Vinatier, C. (2010). Hydrogels for Cartilage Tissue Engineering. In: Ottenbrite, R., Park, K., Okano, T. (eds) Biomedical Applications of Hydrogels Handbook. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5919-5_13

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