Abstract
We propose a method to localise the 3D positions of microcalcifications found in X-ray mammograms using the 3D breast modelling framework of Chung et al. [1]. The accuracy of the method was first studied using a phantom embedded with X-ray visible beads. The phantom was subjected to mammographic-like compressions and imaged under X-ray to determine the positions of the beads. Using these data as inputs, the proposed modelling framework was used to predict the bead positions in the uncompressed phantom, which were also determined experimentally using bi-plane X-ray. The bead locations were reconstructed to within 2.8, 3.6 and 2.1 mm. The proposed method was demonstrated on a clinical case by successfully reconstructing the 3D positions of microcalcifications identified in X-ray mammograms and mapping them to a 3D MR data set of the same breast, demonstrating its potential to reliably track such features across different imaging modalities.
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Acknowledgment
We gratefully acknowledge financial support from the New Zealand Government’s Foundation for Research Science & Technology (UOAX0707). M.P. Nash is supported by a James Cook Fellowship administered by the Royal Society of New Zealand on behalf of the New Zealand Government.
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Rajagopal, V., Chung, JH., Highnam, R.P., Warren, R., Nielsen, P.M., Nash, M.P. (2010). Mapping Microcalcifications Between 2D Mammograms and 3D MRI Using a Biomechanical Model of the Breast. In: Miller, K., Nielsen, P. (eds) Computational Biomechanics for Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5874-7_3
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DOI: https://doi.org/10.1007/978-1-4419-5874-7_3
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