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Biomaterial Surface Characteristics Modulate the Outcome of Bone Regeneration Around Endosseous Oral Implants: In Silico Modeling and Simulation

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Computational Biomechanics for Medicine

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Abstract

Experimental investigations have demonstrated the importance of platelets and their activation for bone regeneration around oral implants. This study aimed to numerically demonstrate the key role of activated platelets which is controlled by implant surface characteristics. The cellular activities involved in the process of peri-implant endosseous healing can be represented by migration, proliferation, differentiation, removal, extracellular matrix synthesis and degradation, and growth factor production/release and decay. These activities are described by a system of highly coupled non-linear partial differential equations of taxis–diffusion–reaction type. Moreover, cell–biomaterial interactions were treated by including surface-specific model parameters. A well-designed in vivo model that looked at healing around oral implants with different surface properties was selected from literature to validate the results. Numerical simulations agreed well with the experimentally observed healing response and demonstrated that platelet-related model parameters, which were dependent on implant surface characteristics, modulate the pattern of healing.

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Acknowledgments

Nadya Amor gratefully acknowledges the Research Council of K.U. Leuven for their financial support. Lies Geris is a postdoctoral research fellow of the Research Foundation Flanders (FWO-Vlaanderen).

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Authors and Affiliations

  1. Division of Biomechanics and Engineering Design, Department of Mechanical Engineering, Katholieke Universiteit Leuven, Heverlee, 3001, Leuven, Belgium

    Nadya Amor, Liesbet Geris, Jos Vander Sloten & Hans Van Oosterwyck

Authors
  1. Nadya Amor
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  2. Liesbet Geris
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  3. Jos Vander Sloten
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  4. Hans Van Oosterwyck
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Corresponding author

Correspondence to Nadya Amor .

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Editors and Affiliations

  1. Intelligent Systems for Medicine Lab., The University of Western Australia, Stirling Highway 35, Crawley/Perth, 6009, Australia

    Karol Miller

  2. Bioengineering Institute, University of Auckland, Symonds Street 70, Auckland, 1030, New Zealand

    Poul M.F. Nielsen

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Amor, N., Geris, L., Vander Sloten, J., Van Oosterwyck, H. (2010). Biomaterial Surface Characteristics Modulate the Outcome of Bone Regeneration Around Endosseous Oral Implants: In Silico Modeling and Simulation. In: Miller, K., Nielsen, P. (eds) Computational Biomechanics for Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5874-7_11

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  • DOI: https://doi.org/10.1007/978-1-4419-5874-7_11

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-5873-0

  • Online ISBN: 978-1-4419-5874-7

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