Exploitation of Genetically Modified Neural Stem Cells for Neurological Disease

  • Allen L. Ho
  • Sassan Keshavarzi
  • Michael L. LevyEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 671)


The successful treatment and potential treatment of the central nervous system (CNS) pathology remains the most challenging frontier in medical science. The clinical modalities presently available are mostly of limited efficacy and with the aging population, neurodegerative diseases and CNS neoplasms are increasingly prevalent.

Neural stem cells (NSCs) have provided optimism for the horizon of therapeutic progress in treating neurological diseases. These mutipotent (able to differentiate into neurons, astrocytes and oligodendrocytes) cells can be obtained directly from the CNS or derived from of embryonic stem cells (ESCs). NSCs can be genetically manipulated in vitro to express desired transgenes for improved expandability, as well as for delivery of toxic payloads. NSCs also demonstrate the ability to engraft within the CNS, migrate to CNS pathology and in certain scenarios to reconstitute the injured or diseased nervous system.


Spinal Cord Injury Amyotrophic Lateral Sclerosis Neural Stem Cell Middle Cerebral Artery Occlusion Neural Progenitor Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2010

Authors and Affiliations

  • Allen L. Ho
    • 1
  • Sassan Keshavarzi
    • 2
  • Michael L. Levy
    • 3
    Email author
  1. 1.Harvard Medical SchoolBostonUSA
  2. 2.Division of NeurosurgeryUCSD Medical CenterSan DiegoUSA
  3. 3.Pediatric NeurosurgeryRady Children’s HospitalSan DiegoUSA

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