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Stem Cell Origin of Brain Tumors

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Frontiers in Brain Repair

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 671))

Abstract

The biology of both normal and tumor development clearly possesses overlapping and parallel features. Oncogenes and tumor suppressors are relevant not only in tumor biology, but also in physiological developmental regulators of growth and differentiation. Conversely, genes identified as regulators of developmental biology are relevant to tumor biology. This is particularly relevant in the context of brain tumors, where recent evidence is mounting that the origin of brain tumors, specifically gliomas, may represent dysfunctional developmental neurobiology. NSCs are increasingly being investigated as the cell type that originally undergoes malignant transformation—the cell of origin—and the evidence for this is discussed.

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Author information

Authors and Affiliations

  1. Division of Neurosurgery, UCSD Medical Center, San Diego, California, USA

    Dawn Waters & Ben Newman

  2. Pediatric Neurosurgery, Rady Children’s Hospital, San Diego, California, USA

    Michael L. Levy

Authors
  1. Dawn Waters
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  2. Ben Newman
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  3. Michael L. Levy
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Corresponding author

Correspondence to Michael L. Levy .

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Editors and Affiliations

  1. Division of Neurosurgery, City of Hope Comprehensive Cancer Center & Beckman Research Institute, Duarte, California, USA

    Rahul Jandial MD, PhD

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Waters, D., Newman, B., Levy, M.L. (2010). Stem Cell Origin of Brain Tumors. In: Jandial, R. (eds) Frontiers in Brain Repair. Advances in Experimental Medicine and Biology, vol 671. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5819-8_5

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