Skip to main content

Understanding Gene, Environment, and Gene × Environment Interaction Effects: The Example of Childhood Externalizing Disorders

  • Chapter
  • First Online:
Handbook of Genomics and the Family

Abstract

In the past, models of children’s social development focused almost exclusively on causal mechanisms believed to be primarily environmental. Oftentimes, parenting styles were implicated as the primary causal factors in the development of children’s social and emotional adjustment (e.g., Bates, Bayles, Bennett, Ridge, & Brown, 1991; Hetherington & Martin, 1979; Patterson, 1982). Peer influence on child behavior has also been researched in depth (Berkowitz & Lundy, 1957; Pravder & Israel, 1983), as were adverse environmental conditions such as poverty (Schweinhart & Weikart, 1988). While these causal pathways each have merit, theories of the origins of children’s adjustment and maladjustment evolved dramatically during the 1990s to consider increasingly complex transactional systems in which psychological, sociological, and genetic factors are interrelated in their influence on child adjustment (Bates et al., 1991; Bronfenbrenner & Ceci, 1994).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 229.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 299.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 449.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Bakermans-Kranenburg, M. J., VanIJzendoorn, M. H., Pijlman, F. T. A., Mesman, J., & Juffer, F. (2008). Experimental evidence for differential susceptibility: Dopamine D4 receptor polymorphism (DRD4 VNTR) moderates intervention effects on toddlers’ externalizing behavior in randomized controlled trial. Developmental Psychology, 44(1), 293–300.

    PubMed  Google Scholar 

  • Bartels, M. (2007). An update on longitudinal twin and family studies. Twin Research and Human Genetics, 10(1), 1–2.

    Google Scholar 

  • Bartels, M., Hudziak, J. J., van den Oord, E. J. C. G., Beijsterveldt, C. E. M., Rietveld, M. J. H., & Boomsma, D. I. (2003). Co-occurrence of aggressive behavior and rule breaking behavior at age 12: Multi-rater analyses. Behavior Genetics, 33(5), 607–621.

    PubMed  Google Scholar 

  • Bartels, M., van Beijsterveldt, C. E. M., Derks, E. M., Stroet, T. M., Polderman, T. J. C., Hudziak, J. J., et al. (2007). Young Netherlands twin register (Y-NTR): A longitudinal multiple informant study of problem behavior. Twin Research and Human Genetics, 10(1), 3–11.

    PubMed  Google Scholar 

  • Bartels, M., van den Oord, E. J. C. G., Hudziak, J. J., Rietveld, M. J. H., van Beijsterveldt, C. E. M., & Boomsma, D. I. (2004). Genetic and environmental mechanisms underlying stability and change in problem behaviors at ages 3, 7, 10, and 12. Developmental Psychology, 40(5), 852–867.

    PubMed  Google Scholar 

  • Bates, J. E., Bayles, K., Bennett, D. S., Ridge, B., & Brown, M. M. (1991). Origins of externalizing behavior problems at eight years of age. In D. J. Pepler & K. H. Rubin (Eds.), The development and treatment of childhood aggression (pp. 93–120). Hillsdale, NJ: Lawrence Erlbaum Associates, Inc.

    Google Scholar 

  • Beaver, K. M., Wright, J. P., DeLisi, M., Daigle, L. E., Swatt, M. L., & Gibson, C. L. (2007a). Evidence of a gene × environment interaction in the creation of victimization: Results from a longitudinal sample of adolescents. International Journal of Offender Therapy and Comparative Criminology, 51(6), 620–645.

    PubMed  Google Scholar 

  • Beaver, K. M., Wright, J. P., DeLisi, M., Walsh, A., Vaughn, M. G., Boisvert, D., et al. (2007b). A gene × gene interaction between DRD2 and DRD4 is associated with conduct disorder and antisocial behavior in males. Behavioral and Brain Functions, 3(1), 30.

    PubMed  Google Scholar 

  • Berkowitz, L., & Lundy, R. M. (1957). Personality characteristics related to susceptibility to influence by peers or authority figures. Journal of Personality, 25, 306–316.

    PubMed  Google Scholar 

  • Boomsma, D. I., Beem, A. L., van den Berg, M., Dolan, C. V., Koopmans, J. R., Vink, J. M., et al. (2000). Netherlands twin family study of anxious depression (NETSAD). Twin Research, 3(4 ), 323–334.

    PubMed  Google Scholar 

  • Boomsma, D. I., de Geus, E. J. C., Vink, J. M., Stubbe, J. H., Distel, M. A., Hottenga, J. J., et al. (2006). Netherlands twin register: From twins to twin families. Twin Research and Human Genetics, 9(6), 849–857.

    PubMed  Google Scholar 

  • Botto, L. D., & Khoury, M. J. (2001). Commentary: Facing the challenge of gene–environment interaction: The 2×4 model and beyond. American Journal of Epidemiology, 153(10), 1016–1020.

    PubMed  Google Scholar 

  • Bouchard, T. J., Lykken, D. T., McGue, M., Segal, N. L., & Tellegen, A. (1990). Sources of human psychological differences: The Minnesota Study of Twins Reared Apart. Science, 250(4978), 223–228.

    PubMed  Google Scholar 

  • Braungart-Rieker, J., Rende, R. D., Plomin, R., & DeFries, J. C. (1995). Genetic mediation of longitudinal associations between family environment and childhood behavior problems. Development and Psychopathology, 7(2), 233–245.

    Google Scholar 

  • Bronfrenbrenner, U., & Ceci, S. J. (1994). Nature-nurture reconceptualized in developmental perspective: A bioecological model. Psychological Review, 101(4), 568–586.

    Google Scholar 

  • Burt, S. A., Krueger, R. F., McGue, M., & Iacono, W. G. (2001). Sources of covariation among attention-deficit/hyperactivity disorder, oppositional defiant disorder, and conduct disorder: The importance of shared environment. Journal of Abnormal Psychology, 110(4), 516–525.

    PubMed  Google Scholar 

  • Burt, S. A., Krueger, R. F., McGue, M., & Iacono, W. (2003). Parent–child conflict and the comorbidity among childhood externalizing disorders. Archives of General Psychiatry, 60, 505–613.

    PubMed  Google Scholar 

  • Burt, S. A., McGue, M., Krueger, R. F., & Iacono, W. (2005). Sources of covariation among the child-externalizing disorders: Informant effects and the shared environment. Psychological Medicine, 35(8), 1133–1144.

    PubMed  Google Scholar 

  • Button, T. M. M., Scourfield, J., Martin, N., Purcell, S., & McGuffin, P. (2005). Family dysfunction interacts with genes in the causation of antisocial symptoms. Behavior Genetics, 35(2), 115–120.

    PubMed  Google Scholar 

  • Cadoret, R. J., Troughton, E., Bagford, J., & Woodworth, G. (1990). Genetic and environmental factors in adoptee antisocial personality. European Archives of Psychiatry and Neurological Sciences, 239(4), 231–240.

    PubMed  Google Scholar 

  • Cadoret, R. J., Yates, W. R., Troughton, E., Woodworth, G., & Stewart, M. A. (1995). Adoption study demonstrating two genetic pathways to drug abuse. Archives of General Psychiatry, 52(1), 42–52.

    PubMed  Google Scholar 

  • Caspi, A., Begg, D., Dickson, N., Harrington, H., Langley, J., Moffitt, T. E., et al. (1997). Personality differences predict health-risk behaviors in young adulthood: Evidence from a longitudinal study. Journal of Personality and Social Psychology, 73(5), 1052–1063.

    PubMed  Google Scholar 

  • Caspi, A., McClay, J., Moffit, T. E., Mill, J., Martin, J., Craig, I. W., et al. (2002). Role of genotype in the cycle of violence in maltreated children. Science, 297, 851–854.

    PubMed  Google Scholar 

  • Charles, S. T., Gatz, M., Pedersen, N. L., & Dahlberg, L. (1999). Genetic and behavioral risk factors for self-reported joint pain among a population-based sample of Swedish twins. Health Psychology, 18(6), 644–654.

    PubMed  Google Scholar 

  • Cleveland, H. H., Wiebe, R. P., van den Oord, E. J. C. G., & Rowe, D. C. (2000). Behavior problems among children from different family structures: The influence of genetic self-selection. Child Development, 71(3), 733–751.

    PubMed  Google Scholar 

  • Coon, H., Carey, G., Corley, R., & Fulker, D. W. (1992). Identifying children in the Colorado Adoption Project at risk for conduct disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 31(3), 503–511.

    PubMed  Google Scholar 

  • Deater-Deckard, K. (2000). Parenting and child behavioral adjustment in early childhood: A quantitative genetic approach to studying family processes. Child Development, 71(2), 468–484.

    PubMed  Google Scholar 

  • Deater-Deckard, K., Fulker, D. W., & Plomin, R. (1999). A genetic study of the family environment in the transition to early adolescence. Journal of Child Psychology and Psychiatry, 40(5), 769–775.

    PubMed  Google Scholar 

  • Defries, J. C., Plomin, R., & Fulker, D. W. (1994). Nature and nurture during middle childhood. Cambridge, MA: Blackwell.

    Google Scholar 

  • Derks, E. M., Hudziak, J. J., Dolan, C. V., van Beijsterveldt, T. C. E. M., Verhulst, F. C., & Boomsma, D. I. (2008). Genetic and environmental influences on the relation between attention problems and attention deficit hyperactivity disorder. Behavior Genetics, 389(1), 11–23.

    Google Scholar 

  • DiLalla, D. L., Carey, G., Gottesman, I. I., & Bouchard, T. J. (1996). Heritability of MMPI personality indicators of psychopathology in twins reared apart. Journal of Abnormal Psychology, 105(4), 491–499.

    PubMed  Google Scholar 

  • Dick, D. M., Viken, R. J., Kaprio, J., Pulkkinen, L., & Rose, R. J. (2005). Understanding the covariation among childhood externalizing symptoms: Genetic and environmental influences on conduct disorder, attention deficit hyperactivity disorder, and oppositional defiant disorder symptoms. Journal of Abnormal Child Psychology, 33(2), 219–229.

    PubMed  Google Scholar 

  • D’Onofrio, B. M., Turkheimer, E., Eaves, L. J., Corey, L. A., Berg, K., Solaas, M. H., et al. (2003). The role of the children of twins design in elucidating causal relations between parent characteristics and child outcomes. Journal of Child Psychology and Psychiatry, 44, 1130–1144.

    PubMed  Google Scholar 

  • D’Onofrio, B. M., Turkheimer, E., Emery, R. E., Heath, A. C., Madden, P. A., Slutske, W. S., et al. (2006). A genetically informed study of the processes underlying the association between parental marital instability and offspring adjustment. Developmental Psychology, 42(3), 486–499.

    PubMed  Google Scholar 

  • Eaves, L., Silberg, J., & Erkanli, A. (2003). Resolving multiple epigenetic pathways to adolescent depression. Journal of Child Psychology and Psychiatry, 44(7), 1006–1014.

    PubMed  Google Scholar 

  • Eaves, L. J., Silberg, J. L., Maes, H. H., Simonoff, E., Pickles, A., Rutter, M., et al. (1997). Genetics and developmental psychopathology: 2. The main effects of genes and environment on behavioral problems in the Virginia Twin Study of Adolescent Behavioral Development. Journal of Child Psychology and Psychiatry, 38(8), 965–980.

    PubMed  Google Scholar 

  • Eley, T. C., Lichtenstein, P., & Moffitt, T. E. (2003). A longitudinal behavioral genetic analysis of the etiology of aggressive and nonaggressive antisocial behavior. Development and Psychopathology, 15(2), 383–402.

    PubMed  Google Scholar 

  • Feinberg, M. E., Button, T. M. M., Neiderhiser, J. M., Reiss, D., & Hetherington, E. M. (2007). Parenting and adolescent antisocial behavior and depression: Evidence of genotype × parenting environment interaction. Archives of General Psychiatry, 64, 457–465.

    PubMed  Google Scholar 

  • Foley, D. L., Eaves, L. J., Wormley, B., Sliberg, J. L., Maes, H. H., Kuhn, J., et al. (2004). Childhood adversity, monoamine oxidase A genotype, and risk for conduct disorder. Archives of General Psychiatry, 61, 738–744.

    PubMed  Google Scholar 

  • Ganiban, J. M., Spotts, E. L., Lichtenstein, P., Khera, G. S., Reiss, D., & Neiderhiser, J. M. (2007). Can genetic factors explain the spillover of warmth and negativity across family relationships? Twin Research and Human Genetics, 10(2), 299–313.

    PubMed  Google Scholar 

  • Ge, X., Conger, R. D., Cadoret, R. J., Neiderhiser, J. M., Yates, W., Troughton, E., et al. (1996). The developmental interface between nature and nurture: A mutual influence model of child antisocial behavior and parent behaviors. Developmental Psychology, 32(4), 574–589.

    Google Scholar 

  • Gelhorn, H. L., Stallings, M. C., Young, S. E., Corley, R. P., Rhee, S. H., & Hewitt, J. K. (2005). Genetic and environmental influences on conduct disorder: Symptom, domain and full-scale analyses. Journal of Child Psychology and Psychiatry, 46(6), 580–591.

    PubMed  Google Scholar 

  • Goldsmith, H. H., Lemery-Chalfant, K., Schmidt, N. L., Arneson, C. L., & Schmidt, C. K. (2007). Longitudinal analyses of affect, temperament, and childhood psychopathology. Twin Research and Human Genetics, 10(1), 119–126.

    Google Scholar 

  • Gottesman, I. I. (1963). Heritability of personality: A demonstration. Psychological Monographs: General and applied, 77(9), 1–21.

    Google Scholar 

  • Hann, D. M., & Borek, N. (Eds.). (2001). Taking stock of risk factors for child/youth externalizing behavior problems. Retrieved February 15, 2008, from http://www.tourettesyndrome.net/Files/takingstock.pdf

  • Harden, K. P., Turkheimer, E., Emery, R. E., D’Onofrio, B. M., Slutske, W. S., Heath, A. C., et al. (2007). Marital conflict and conduct problems in children of twins. Child Development, 78(1), 1–18.

    PubMed  Google Scholar 

  • Harris, K. M., Halpern, C. T., Smolen, A., & Haberstick, B. C. (2006). The national longitudinal study of adolescent health (add health) twin data. Twin Research and Human Genetics, 9(6), 988–997.

    PubMed  Google Scholar 

  • Haugaard, J. J., & Hazan, C. (2003). Adoption as a natural experiment. Development and Psychopathology, 15, 909–926.

    PubMed  Google Scholar 

  • Hetherington, E. M., & Martin, B. (1979). Family interaction. In H. C. Quay & J. S. Werry (Eds.), Psychopathological disorders of childhood (pp. 247–302). New York: Wiley.

    Google Scholar 

  • Jaffee, S. R., & Price, T. S. (2007). Gene–environment correlations: A review of the evidence and implications for prevention of mental illness. Molecular Psychiatry, 12(5), 432–442.

    PubMed  Google Scholar 

  • Kendler, K. S. (1997). The genetic epidemiology of psychiatric disorders: A current perspective. Social Psychiatry and Psychiatric Epidemiology, 32(1), 5–11.

    PubMed  Google Scholar 

  • Kendler, K. S., & Baker, J. H. (2007). Genetic influences on measures of the environment: A systematic review. Psychological Medicine, 37, 615–626.

    PubMed  Google Scholar 

  • Kendler, K. S., Kuhn, J. W., VIttum, J., Prescott, C. A., & Riley, B. (2005). The interaction of stressful life events and a serotonin expression polymorphism in the prediction of episodes of major expression. Archives of General Psychiatry, 62, 525–539.

    Google Scholar 

  • Kim-Cohen, J., Caspi, A., Taylor, A., Williams, B., Newcombe, R., Craig, I. W., et al. (2006). MAOA, maltreatment, and gene–environment interaction predicting children’s mental health: New evidence and a meta-analysis. Molecular Psychiatry, 11(10), 903–913.

    PubMed  Google Scholar 

  • Kim-Cohen, J., Moffitt, T. E., Caspi, A., & Taylor, A. (2004). Genetic and environmental processes in young children’s resilience and vulnerability to socioeconomic deprivation. Child Development, 75(3), 651–668.

    PubMed  Google Scholar 

  • Klein, D. N., Lewinsohn, P. M., Seeley, J. R., & Rohde, P. (2001). A family study of major depressive disorder in a community sample of adolescents. Archives of General Psychiatry, 58(1), 13–20.

    PubMed  Google Scholar 

  • Klump, K. L., Burt, A. S., McGue, M., & Iacono, W. G. (2007). Changes in genetic and environmental influences on disordered eating across adolescence: A twin study. Archives of General Psychiatry, 64(12), 1409–1415.

    PubMed  Google Scholar 

  • Lander, E. S. and Schork, N. J. (2006). Genetic dissection of complex traits. American Psychiatric Association Focus, 4, 442–458.

    Google Scholar 

  • Langinvainio, H., Koskenvuo, M., Kaprio, J., & Sistonen, P. (1984). Finnish twins reared apart: II. Validation of zygosity, environmental dissimilarity and weight and height. Acta Geneticae Medicae et Gemellologiae: Twin Research, 33(2), 251–258.

    PubMed  Google Scholar 

  • Leve, L. D., Neiderhiser, J. M., Ge, X., Scaramella, L. V., Conger, R. D., Reid, J. B., et al. (2007). The early growth and development study: A prospective adoption design. Twin Research and Human Genetics, 10(1), 84–95.

    PubMed  Google Scholar 

  • Leve, L. D., Neiderhiser, J. M., Scaramella, L. V., & Reiss, D. (2008). The Early Growth and Development Study: Using the prospective adoption design to examine genotype-environment interplay. Acta Psychologica Sinica, 40(10), 1106–1115.

    Google Scholar 

  • Lichtenstein, P., Pedersen, N. L., & McClearn, G. E. (1992). Origins of individual differences in occupational status and educational level: A study of twins reared apart and together. Acta Sociologica, 35, 13–31.

    Google Scholar 

  • Lichtenstein, P., Tuvblad, C., Larsson, H., & Carlstrom, E. (2007). A Swedish twin study of CHild and adolescent development: The TCHAD-study. Twin Research and Human Genetics, 10(1), 67–73.

    PubMed  Google Scholar 

  • Loehlin, J. C. (1996). The cholesky approach: A cautionary note. Behavior Genetics, 26(1), 65–69.

    Google Scholar 

  • Loehlin, J. C., Neiderhiser, J. M., & Reiss, D. (2005). Genetic and environmental components of adolescent adjustment and parental behavior: A multivariate analysis. Child Development, 76(5), 1104–1115.

    PubMed  Google Scholar 

  • Losoya, S. H., Callor, S., Rowe, D., & Goldsmith, H. H. (1997). Origins of familial similarity in parenting: A study of twins and adoptive siblings. Developmental Psychology, 33(6), 1012–1–23.

    Google Scholar 

  • Lynch, S. K., Turkheimer, E., D’Onofrio, B. M., Mendle, J., Emery, R. E., Slutske, W. S., et al. (2006). A genetically informed study of the association between harsh punishment and offspring behavior problems. Journal of Family Psychology, 20(2), 190–198.

    PubMed  Google Scholar 

  • McGue, M., Keyes, M., Sharma, A., Elkins, I., Legrand, L., Johnson, W., et al. (2007). The environments of adopted and non-adopted youth: Evidence on range restriction from the sibling interaction and behavior study (SIBS). Behavior Genetics, 37(3), 449–462.

    PubMed  Google Scholar 

  • Mendle, J., Turkheimer, E., D’Onofrio, B. M., Lynch, S. K., Emery, R. E., Slutske, W. S., et al. (2006). Family structure and age at menarche: A children-of-twins approach. Developmental Psychology, 42(3), 533–542.

    PubMed  Google Scholar 

  • Merikangas, K. R., & Swendsen, J. D. (1997). Genetic epidemiology of psychiatric disorders. Epidemiological Reviews, 19(1), 144–155.

    Google Scholar 

  • Miles, D. R., & Carey, G. (1997). Genetic and environmental architecture of human aggression. Journal of Personality and Social Psychology, 72(1), 207–217.

    PubMed  Google Scholar 

  • Moffitt, T. E., Caspi, A., & Rutter, M. (2005). Strategy for investigating interactions between measured genes and measured environments. Archives of General Psychiatry, 62, 473–481.

    PubMed  Google Scholar 

  • Nadder, T. S., Silberg, J. L., Eaves, L. J., Maes, H. H., & Meyer, J. M. (1998). Genetic effects on ADHD symptomatology in 7- to 13-year-old twins: Results from a telephone survey. Behavior Genetics, 28(2), 83–99.

    PubMed  Google Scholar 

  • Narusyte, J., Andershed, A., Neiderhiser, J. M., & Lichtenstein, P. (2007). Aggression as a mediator of genetic contributions to the association between negative parent–child relationships and adolescent antisocial behavior. European Child and Adolescent Psychiatry, 16(2), 128–137.

    PubMed  Google Scholar 

  • Narusyte, J., Neiderhiser, J. M., D’Onofrio, B. M., Reiss, D., Spotts, E. L., Ganiban, J., & Lichtenstein, P. (2008). Testing different types of genotype–environment correlation: An extended children-of-twins model. Developmental Psychology, 44(6), 1591–1603.

    Google Scholar 

  • Neiderhiser, J. M. (2001). Understanding the roles of genome and envirome: Methods in genetic epidemiology. British Journal of Psychiatry, 178(40), s12–s17.

    Google Scholar 

  • Neiderhiser, J. M., & Lichtenstein, P. (2008). The Twin and Offspring Study in Sweden: Advancing our understanding of genotype-environment interplay by studying twins and their families. Acta Psychologica Sinica, 40(10), 1116–1123.

    Google Scholar 

  • Neiderhiser, J. M., Reiss, D., & Hetherington, M. E. (2007). The Nonshared Environment in Adolescent Development (NEAD) project: A longitudinal family study of twins and siblings from adolescence to young adulthood. Twin Research and Human Genetics, 10(1), 74–83.

    PubMed  Google Scholar 

  • Neiderhiser, J. M., Reiss, D., Hetherington, E. M., & Plomin, R. (1999). Relationships between parenting and adolescent adjustment over time: Genetic and environmental contributions. Developmental Psychology, 35(3), 680–692.

    Google Scholar 

  • Neiderhiser, J. M., Reiss, D., Pedersen, N. L., Lichtenstein, P., Spotts, E. L., Hansson, K., et al. (2004). Genetic and environmental influences on mothering of adolescents: A comparison of two samples. Developmental Psychology, 40(3), 335–351.

    PubMed  Google Scholar 

  • Newman, D. L., Caspi, A., Moffitt, T. E., & Silva, P. A. (1997). Antecedents of adult interpersonal functioning: Effects of individual differences in age 3 temperament. Developmental Psychology, 33(2), 206–217.

    PubMed  Google Scholar 

  • Owen, D. R., & Sines, J. O. (1970). Heritability of personality in children. Behavior Genetics, 1, 235–248.

    PubMed  Google Scholar 

  • O’Connor, T. (2006). Toward integrating behavioral genetics and family process. Family, Systems, and Health, 24(4), 416–424.

    Google Scholar 

  • O’Connor, T. G., McGuire, S., Reiss, D., Hetherington, E. M., & Plomin, R. (1998). Co-occurrence of depressive symptoms and antisocial behavior in adolescence: A common genetic liability. Journal of Abnormal Psychology, 107(1), 27–37.

    PubMed  Google Scholar 

  • O’Connor, T. G., Neiderhiser, J. M., Reiss, D., Hetherington, E. M., & Plomin, R. (1998). Genetic contributions to continuity, change, and co-occurrence of antisocial and depressive symptoms in adolescence. Journal of Child Psychology and Psychiatry, 39(3), 323–336.

    PubMed  Google Scholar 

  • Patterson, G. R. Coercive family process: A social learning approach (Vol. 3). Eugene, Oreg.: Castalia, 1982.

    Google Scholar 

  • Pedersen, N. L., Plomin, R., McClearn, G. E., & Friberg, L. (1988). Neuroticism, extraversion, and related traits in adult twins reared apart and reared together. Journal of Personality and Social Psychology, 55(6), 950–957.

    Google Scholar 

  • Plomin, R. (1990). Nature and nurture: An introduction to human behavioral genetics. Belmont, CA: Wadsworth, Inc.

    Google Scholar 

  • Plomin, R., & DeFries, J. C. (1985). Origins of individual differences in infancy: The Colorado adoption project. Orlando, FL: Academic Press.

    Google Scholar 

  • Plomin, R., DeFries, J., & Loehlin, J. C. (1977). Genotype-environment interaction and correlation in the analysis of human behavior. Psychological Bulletin, 84(2), 309–322.

    PubMed  Google Scholar 

  • Plomin, R., Nitz, K., & Rowe, D. C. (1990). Behavioral genetics and aggressive behavior in childhood. In M. Lewis & S. M. Miller (Eds.), Handbook of developmental psychopathology. New York: Plenum.

    Google Scholar 

  • Plomin, R., Owen, M. J., & McGuffin, P. (1994). The genetic basis of complex human behaviors. Science, 264(5166), 1733–1739.

    Google Scholar 

  • Pravder, M. D., & Israel, A. C. (1983). The effect of peer influence systems on children’s coercive behavior. Journal of Clinical Child Psychology, 12(2), 145–152.

    Google Scholar 

  • Purcell, S. (2002). Variance components models for gene–environment interaction n in twin analysis. Twin Research, 5(6), 554–571.

    PubMed  Google Scholar 

  • Reddy, P. S., Reddy, Y. C. J., Srinath, S., Khanna, S., Sheshadri, S. P., & Girimaji, S. R. A. (2001). A family study of juvenile obsessive-compulsive disorder. The Canadian Journal of Psychiatry, 46(4), 346–351.

    Google Scholar 

  • Reiss, D., Hetherington, E. M., Plomin, R., Howe, G. W., Simmens, S. J., Henderson, S. H., et al. (1995). Genetic questions for environmental studies: Differential parenting and psychopathology in adolescence. Archives of General Psychiatry, 529(11), 925–936.

    Google Scholar 

  • Reiss, D., & Leve, L. (2007). Genetic expression outside the skin: Clues to the mechanisms of Genotype × Environment interaction. Developmental Psychopathology, 19, 1005–10027.

    Google Scholar 

  • Reiss, D., Neiderhiser, J. M., Hetherington, E. M., & Plomin, R. (2000). The relationship code: Deciphering genetic and social influences on adolescent development. Cambridge, MA: Harvard University Press.

    Google Scholar 

  • Reiss, D., Pedersen, N. L., Cederblad, M., Lichtenstein, P., Hansson, K., Neiderhiser, J. M., et al. (2001). Genetic probes of three theories of maternal adjustment: I. Recent evidence and a model. Family Process, 40(3), 247–259.

    PubMed  Google Scholar 

  • Reiss, D. (2008). Social processes and genetic influences in child development: Novel uses of twin and adoption studies. Acta Psychologica Sinica, 40(10), 1099–1105 .

    Google Scholar 

  • Rende, R. D., & Plomin, R. (1992). Relations between first-grade stress, temperament, and behavior problems. Journal of Applied Developmental Psychology, 13(4), 435–446.

    Google Scholar 

  • Rende, R., Slomkowski, C. L., Stocker, C., Fulker, D. W., & Plomin, R. (1992). Genetic and environmental influences on maternal and sibling interaction in middle childhood: A sibling adoption study. Developmental Psychology, 17, 203–208.

    Google Scholar 

  • Reznikoff, M., & Honeyman, M. S. (1967). MMPI profiles of monozygotic and dizygotic twin pairs. Journal of Consulting Psychology, 31(1), 100.

    Google Scholar 

  • Riggins-Caspers, K. M., Cadoret, R. J., Knutson, J. F., & Langehn, D. (2003). Biology-environment correlation: Contributions of harsh discipline and parental psychopathology to problem adolescent behaviors. Behavior Genetics, 33(3), 205–220.

    PubMed  Google Scholar 

  • Rubin, K. H., Burgess, K., & Coplan, R. (2002). Social inhibition and withdrawal in childhood. In P. K. Smith & C. Hart (Eds.), Handbook of childhood socia development. London: Blackwell.

    Google Scholar 

  • Rubin, K. H., Dwyer, K. M., Booth, C. L., Kim, A. H., Burgess, K. B., & Rose-Krasnor, L. (2004). Attachment, friendship, and psychosocial functioning in early adolescence. Journal of Early Adolescence, 24, 326–356.

    PubMed  Google Scholar 

  • Rutter, M., Macdonald, H., Le Couteur, A., Harrington, R., Bolton, P., & Bailey, A. (1990). Genetic factors in child psychiatric disorders-II: Empirical findings. Journal of Child Psychology and Psychiatry, 31(1), 39–83.

    PubMed  Google Scholar 

  • Rutter, M., Moffitt, T. E., & Caspi, A. (2006). Gene–environment interplay and psychopathology: Multiple varieties but real effects. Journal of Child Psychology and Psychiatry, 47(3–4), 226–261.

    PubMed  Google Scholar 

  • Rutter, M., & Silberg, J. (2002). Gene–environment interplay in relation to emotional and behavioral disturbance. Annual Review of Psychology, 53, 463–490.

    PubMed  Google Scholar 

  • Saudino, K., & Plomin, R. (2007). Why are hyperactivity and academic achievement related? Child Development, 78(3), 972–986.

    PubMed  Google Scholar 

  • Scarr, S., & McCartney, K. (1988). How people make their own environments: A theory of genotype -> environment effects. Child Development, 54, 424–435.

    Google Scholar 

  • Schweinhart, L. J., & Weikart, D. P. (1988). Early childhood education for at-risk four-year-olds? Yes. American Psychologist, 43(8), 665–667.

    Google Scholar 

  • Scourfield, J., Van den Bree, M., Martin, N., & McGuffin, P. (2004). Conduct problems in children and adolescents: A twin study. Archives of General Psychiatry, 61(5), 489–496.

    PubMed  Google Scholar 

  • Sham, P. (1996). Genetic epidemiology. British Medical Bulletin, 52(2), 408–433.

    PubMed  Google Scholar 

  • Silberg, J. L., & Eaves, L. J. (2004). Analysing the contributions of genes and parent–child interaction to childhood behavioural and emotional problems: A model for the children of twins. Psychological Medicine, 34(2), 347–356.

    PubMed  Google Scholar 

  • Slutske, W. S., Heath, A. C., Dinwiddie, S. H., Madden, P. A. F., Bucholz, K. K., Dunne, M. P., et al. (1997). Modeling genetic and environmental influences in the etiology of conduct disorder: A study of 2,682 adult twin pairs. Journal of Abnormal Psychology, 106(2), 266–279.

    PubMed  Google Scholar 

  • Spotts, E. L., Neiderhiser, J. M., Hetherington, E. M., & Reiss, D. (2001). The relation between observational measures of social problem solving and familial antisocial behavioral: Genetic and environmental influences. Journal of Research on Adolescence, 11(4), 351–374.

    Google Scholar 

  • Stoolmiller, M. (1999). Implications of the restricted range of family environments for estimates of heritability and nonshared environment in behavior-genetic adoption studies. Psychological Bulletin, 125(4), 392–409.

    PubMed  Google Scholar 

  • Tackett, J. L., Krueger, R. F., Iacono, W. G., & McGue, M. (2005). Symptom –based subfactors of DSM-Defined conduct disorder: Evidence for etiologic distinctions. Journal of Abnormal Psychology, 114(3), 483–487.

    PubMed  Google Scholar 

  • Tellegen, A., Lykken, D. T., Bouchard, T. J., Wilcox, K. J., Segal, N. L., & Rich, S. (1988). Personality similarity in twins reared apart and together. Journal of Personality and Social Psychology, 54(6), 1031–1039.

    PubMed  Google Scholar 

  • Tienari, P. (1991). Interaction between genetic vulnerability and family environment: The Finnish adoptive family study of schizophrenia. Acta Psychiatrica Scandinavica, 84, 460–465.

    PubMed  Google Scholar 

  • Truett, K. R., Eaves, L. J., Walters, E. E., Heath, A. C., Hewitt, J. K., Meyer, J. M., et al. (1994). A model system for analysis of family resemblance in extended kinships of twins. Behavior Genetics, 24(1), 35–49.

    PubMed  Google Scholar 

  • Ulbricht, J. A. & Neiderhiser, J. M. (2009). In Kim, Yong-Kyu (Ed.), Handbook of behavior genetics (pp. 209–221). New York, NY, US: Springer Science + Business Media.

    Google Scholar 

  • van Beijsterveldt, C. E. M., Bartels, M., Hudziak, J. J., & Boomsma, D. I. (2003). Causes of stability of aggression from early childhood to adolescence: A longitudinal genetic analysis in Dutch twins. Behavior Genetics, 33(5), 591–605.

    PubMed  Google Scholar 

  • van den Bree, M. B. M., Rice, F., Fowler, T. A., Shelton, K. H., Lifford, K. J., Scourfield, J., et al. (2007). The Cardiff Study of All Wales and North West of England Twins (CaStANET): A longitudinal research program of child and adolescent development. Twin Research and Human Genetics, 10(1), 13–23.

    PubMed  Google Scholar 

  • Viken, R. J., Kaprio, J., & Rose, R. J. (2007). Personality at age 16 and 17 and drinking problems at ages 18 and 25: Genetic analyses of data from FinnTwin16-25. Twin Research and Human Genetics, 10(1), 25–32.

    PubMed  Google Scholar 

  • Waldman, I. D. (2007). Behavior genetic approaches are integral for understanding the etiology of psychopathology. In L. Scott & W. O’Donohue (Eds.), The great ideas of clinical science: 17 principles that every mental health professional should understand (pp. 219–242). New York: Routledge/Taylor & Francis Group.

    Google Scholar 

  • Weiss, N. S. (2007). Assessing the influence of a genetic characteristic on disease in the presence of strong environmental etiology. Epidemiology, 18(4), 429–430.

    PubMed  Google Scholar 

  • Wickramaratne, P. J., Warner, V., & Weissman, M. M. (2000). Selecting early onset MDD probands for genetic studies: Results from a longitudinal high-risk study. American Journal of Medical Genetics, 96, 93–101.

    PubMed  Google Scholar 

  • Young, S. E., Smolen, A., Hewitt, J. K., Haperstick, B. C., Stallings, M. C., Corley, R. P., et al. (2006). Interaction between MAO-A genotype and maltreatment in the risk for conduct disorder: Failure to confirm in adolescent patient. American Journal of Psychiatry, 163, 1019–1024.

    PubMed  Google Scholar 

  • Zhao, L. P., Hsu, L., Davidov, O., Potter, J., Elston, R. C., & Prentice, R. L. (1997). Population-based family study designs: An interdisciplinary research framework for genetic epidemiology. Genetic Epidemiology, 14, 365–388.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Evrony, H., Ulbricht, J., Neiderhiser, J.M. (2010). Understanding Gene, Environment, and Gene × Environment Interaction Effects: The Example of Childhood Externalizing Disorders. In: Tercyak, K. (eds) Handbook of Genomics and the Family. Issues in Clinical Child Psychology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-5800-6_3

Download citation

Publish with us

Policies and ethics