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Atherosclerosis in the Rheumatic Diseases: Compounding the Age Risk

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Geriatric Rheumatology

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Abstract

In geriatrics, atherosclerosis is a common ­comorbidity, since aging is the strongest risk factor for its development. Patients with autoimmune rheumatic disease have an increased risk of atherosclerotic cardiovascular ­disease (ASCVD) morbidity and mortality. Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) have been studied the most, but other autoimmune diseases may confer the risk of ASCVD as well. In addition to traditional risk factors, systemic inflammation likely contributes to ASCVD risk. Atherosclerosis is considered an inflammatory process, and may be accelerated by systemic inflammation. ASCVD risk reduction can be targeted by aggressive management of ASCVD risk factors and the primary rheumatic disease.

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  1. Education Veterans Administration Medical Center, University of Pennsylvania, 3900 Woodland Ave Rm 948A, Philadelphia, PA, 19104, USA

    Joan M. Von Feldt (Associate Chief of Staff)

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  1. Naoto Yokogawa
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    Yuri Nakasato

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    Raymond L. Yung

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Yokogawa, N., Von Feldt, J.M. (2011). Atherosclerosis in the Rheumatic Diseases: Compounding the Age Risk. In: Nakasato, Y., Yung, R. (eds) Geriatric Rheumatology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5792-4_3

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