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Inorganic Nanoporous Membranes for Immunoisolated Cell-Based Drug Delivery

  • Chapter
Therapeutic Applications of Cell Microencapsulation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 670))

Abstract

Materials advances enabled by nanotechnology have brought about promising approaches to improve the encapsulation mechanism for immunoisolated cell-based drug delivery. Cell-based drug delivery is a promising treatment for many diseases but has thus far achieved only limited clinical success. Treatment of insulin dependent diabetes mellitus (IDDM) by transplantation of pancreatic β-cells represents the most anticipated application of cell-based drug delivery technology. This review outlines the challenges involved with maintaining transplanted cell viability and discusses how inorganic nanoporous membranes may be useful in achieving clinical success.

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Authors and Affiliations

  1. UCSF/UCB Joint Graduate Group in Bioengineering, University of California, San Francisco, University of California, Berkeley, USA

    Adam Mendelsohn & Tejal Desai

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  1. Adam Mendelsohn
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  2. Tejal Desai
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  1. Laboratory of Pharmacy and Pharmaceutical Technology, University of the Basque Country, Vitoria-Gasteiz, Spain

    José Luis Pedraz PHD  & Gorka Orive PhD  & 

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Mendelsohn, A., Desai, T. (2010). Inorganic Nanoporous Membranes for Immunoisolated Cell-Based Drug Delivery. In: Pedraz, J.L., Orive, G. (eds) Therapeutic Applications of Cell Microencapsulation. Advances in Experimental Medicine and Biology, vol 670. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5786-3_10

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