Acute Myeloid Leukemia with Myelodysplasia-Related Changes and Therapy-Related Acute Myeloid Leukemia

  • Sergej N. Konoplev
  • Carlos E. Bueso-Ramos
Part of the Molecular Pathology Library book series (MPLB, volume 4)


Acute myeloid leukemia (AML) is a heterogeneous clonal malignant disorder resulting from genetic alterations in multipotent hematopoietic stem cells. These alterations limit the ability of stem cells to differentiate into erythrocytes, granulocytes, and platelets and lead to the proliferation of leukemic cells or blasts.


Acute Myeloid Leukemia Leukemia Stem Cell Multilineage Dysplasia Acute Monocytic Leukemia Normal Hematopoietic Stem Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We thank Kimberly J.T. Herrick for her accurate and helpful editorial suggestions and La Kisha Rodgers and Geneva Williams for their secretarial support.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Sergej N. Konoplev
    • 1
  • Carlos E. Bueso-Ramos
    • 1
  1. 1.Department of HematopathologyThe University of Texas MD Anderson Cancer CenterHoustonUSA

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