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Prognostic Markers

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Molecular Pathology of Hematolymphoid Diseases

Part of the book series: Molecular Pathology Library ((MPLB,volume 4))

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Abstract

The prognosis of hematolymphoid neoplasms varies greatly, not only between different entities but also among tumors that have the same diagnoses. Clinical variation among similar tumors is due largely to genetic and molecular diversity as well as hosts related issues, e.g., age of patient. Molecular and/or genetic variation among similar tumors may reflect differences in a particular tumor pathogenesis relative to others and/or acquisition of additional molecular abnormalities leading to a further loss of normal cell growth control mechanisms. Interpreting studies that correlate clinical outcome and other data with molecularly defined differences among similar neoplasms may be complicated by different therapeutic regimens among different studies, as well differences in which specific clinical parameters are evaluated. For example, overall survival, time to first treatment, and risk of relapse may all yield different results for a given prognostic marker. In spite of these complications, molecular prognostic markers have the potential to tie tumor biology to clinical behavior in individual patients and therefore, may be more informative than those based on stage or other clinical or laboratory data. In addition, molecular techniques may be used to follow levels of minimal residual disease and to better monitor responses to therapy, which is one of the most important general prognostic markers identified to date. The molecular and genomic prognostic markers discussed in this chapter for several specific diseases represent those that have recently been shown to have clinical utility or have the most clinical potential (Table 3.1). The discussion of other molecular/genomic markers that may also have prognostic significance may be found in later chapters devoted to specific hematolymphoid neoplasms.

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  1. Department of Pathology, University of Utah, Salt Lake City, UT, USA

    David Bahler MD, PhD

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  1. Dept. Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, 27599-7525, USA

    Cherie H. Dunphy

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Bahler, D. (2010). Prognostic Markers. In: Dunphy, C. (eds) Molecular Pathology of Hematolymphoid Diseases. Molecular Pathology Library, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-5698-9_3

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