Precursor T-Cell Neoplasms

  • Kim De Keersmaecker
  • Adolfo Ferrando
Chapter
Part of the Molecular Pathology Library book series (MPLB, volume 4)

Abstract

Precursor T-cell lymphoblastic leukemias and lymphomas represent 15% of childhood acute lymphoblastic leukemias (ALLs) and one third of pediatric non-Hodgkin lymphomas, respectively. T-cell ALLs are characterized by prominent (>30%) bone marrow (BM) infiltration with or without mediastinal mass, while T-cell lymphoblastic lymphomas show mediastinal masses in the context of limited or no BM involvement. These two clinical entities share a similar spectrum of molecular and cytogenetic abnormalities, and most probably represent different manifestations of the same disease, commonly designated here as T-ALL.

Keywords

Lymphoma Codon Leukemia Recombination Polypeptide 

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Kim De Keersmaecker
    • 1
    • 2
  • Adolfo Ferrando
    • 3
  1. 1.Departments of Pediatrics and PathologyColumbia University Medical CenterNew YorkUSA
  2. 2.Department of Molecular and Developmental Genetics-VIBCenter for Human Genetics, K.U. Leuven HospitalLeuvenBelgium
  3. 3.Institute for Cancer Genetics, Columbia UniversityNew YorkUSA

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