Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

  • Patricia Aoun
Part of the Molecular Pathology Library book series (MPLB, volume 4)


Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is a clonal lymphoproliferative disorder of morphologically and immunophenotypically mature small B-cells that accumulate in the peripheral blood (PB), bone marrow, lymph nodes, spleen, and other extramedullary sites. In the majority of cases, the neoplastic B-cells exhibit a low mitotic rate and a high resistance to apoptosis. The criteria for diagnosis of chronic lymphocytic leukemia (CLL) have been updated recently by the International Workshop on Chronic Lymphocytic Leukemia. For a diagnosis of CLL, the revised recommendations require the presence of an absolute B-cell lymphocytosis of at least 5.0 × 109/L persisting for greater than 3 months and expressing the characteristic immunophenotype (i.e., CD5+/CD19+/CD20+dim/CD23+/monotypic light chaindim). The clonal B-cells are typically negative (or only weakly positive) for CD79b and FMC7. Cases in which the number of clonal B-cells in the PB is less than 5.0 × 109/L may be diagnosed as CLL if cytopenias or disease-related symptoms are present, or as SLL if lymphadenopathy and/or splenomegaly are present and the diagnosis is confirmed by tissue biopsy.


Chronic Lymphocytic Leukemia Ataxia Telangiectasia Mutate Chronic Lymphocytic Leukemia Patient Chronic Lymphocytic Leukemia Cell Immunoglobulin Heavy Chain Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Patricia Aoun
    • 1
  1. 1.Department of Pathology and MicrobiologyUniversity of Nebraska Medical CenterOmahaUSA

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