Cholinergic Sensitivity of the Developing Bullfrog (Rana catesbeiana) does not Explain Vulnerability to Chronic Nicotine Exposure
Juvenile bullfrogs previously identified as highly sensitive to acute nicotine, demonstrated normal neuroventilation following 3 wk of chronic nicotine exposure. Acute bath application of 1 μM galantamine, an acetylcholinesterase inhibitor, significantly attenuated both bullfrog normocapnic neuroventilation and response to hypercapnia in a fashion similar to that of acute nicotine. This would suggest that the developmental increase in nicotine sensitivity does not enhance vulnerability to chronic exposure, and that acute nicotine acts via endogenous acetylcholine pathways to depress neuroventilation and hypercapnic drive.
KeywordsDepression Attenuation Nicotine Alkaloid Acetylcholine
- Brundage, C.M., Cartagena, C.M., Potter, E.A., and Taylor, B.E. (2009) Nicotine elicits a developmentally dependent depression in bullfrog neuroventilation. Respir. Physiol. Neurobiol. ( In press).Google Scholar
- Eugenin, J., Otarola, M., Bravo, E., Coddou, C., Cerpa, V., Reyes-Parada, M., Llona, I., and von Bernhardi, R. (2008) Prenatal to early postnatal nicotine exposure impairs central chemoreception and modifies breathing pattern in mouse neonates: A probable link to sudden infant death syndrome. J. Neurosci. 28, 13907–13917.CrossRefPubMedGoogle Scholar
- Morguchi, S., Shioda, N., Han, F., Yeh, J.Z., Narahashi, T., and Fukunaga, K. (2009) Galantamine enhancement of long-term potentiation is mediated by calcium/calmodulin-dependent protein kinase II and protein kinase C activation. Hippocampus Feb 27 [ Epub ahead of print].Google Scholar