Cholinergic Sensitivity of the Developing Bullfrog (Rana catesbeiana) does not Explain Vulnerability to Chronic Nicotine Exposure

Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 669)

Abstract

Juvenile bullfrogs previously identified as highly sensitive to acute nicotine, demonstrated normal neuroventilation following 3 wk of chronic nicotine exposure. Acute bath application of 1 μM galantamine, an acetylcholinesterase inhibitor, significantly attenuated both bullfrog normocapnic neuroventilation and response to hypercapnia in a fashion similar to that of acute nicotine. This would suggest that the developmental increase in nicotine sensitivity does not enhance vulnerability to chronic exposure, and that acute nicotine acts via endogenous acetylcholine pathways to depress neuroventilation and hypercapnic drive.

Keywords

Depression Attenuation Nicotine Alkaloid Acetylcholine 

References

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Institute of Arctic BiologyUniversity of Alaska FairbanksFairbanksUSA
  2. 2.Department of Chemistry and BiochemistryUniversity of Alaska FairbanksFairbanksUSA
  3. 3.Institute of Arctic BiologyUniversity of Alaska FairbanksFairbanksUSA

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