How Does Stress Work? The Role of Memes in Epigenesis
Stress responsiveness is affected by early experience. For example, in rats, high grooming and licking by mother in early life results in decreased reactivity to later stress by increasing the expression of glucocorticoid receptor genes in the brain. Memories of early experience and resulting changes in genes (epigenesis) determine stress sensitivity in later life. Epigenesis may result in increased or decreased susceptibility to influx of stress memes.
KeywordsCorticosteroid Cortisol Schizophrenia Adenosine Serotonin
- Baylin, S. (2001) DNA methylation and epigenetic mechanisms of carcinogenesis. Dev Biol (Basel), 106, 85–87, discussion 143–160.Google Scholar
- Dawkins, R. (1976) The Selfish Gene. Oxford University Press, New York.Google Scholar
- Selye, H. (1956) The Stress of Life. McGraw Hill, New York.Google Scholar
- Sterling, P., Eyer, J. (1988) Allostasis: A new paradigm to explain arousal pathology. In Handbook of Life Stress, Cognition and Health (J. Reason and S. Fisher eds.), pp. 629–649. Wiley, New York.Google Scholar