Skip to main content
SpringerLink
Log in

Miscellaneous Manifestations of Behçet’s Disease

  • Chapter
  • First Online:
Behçet’s Syndrome

Abstract

Behçet’s disease is infrequently associated with hematological, auditory, renal, and urological abnormalities. The most significant hematological alteration is the myelodysplastic syndrome, usually linked to trisomy 8. The development of BD-like symptoms in patients with chronic myelogenous leukemia has also been reported. Hearing loss, mostly of the sensorineural type seems to be more common than generally realized. It is usually indolent in nature and may be uni or bilateral. Renal involvement is rare as contrasted to the ANCA-associated vasculitides. However, it may be seen in the form of AA amyloidosis or as glomerulonephritis. Renal vascular disease or interstitial involvement may occasionally be observed. Successful transplantation in end-stage renal disease has been reported. Primary bladder involvement due to vasculitis and secondary involvement due to neuro-Behçet are examples of urological manifestations. They usually present with hematuria or voiding difficulties. Epididymitis and impotence are also seen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Rosenthal NS, Farhi DC (1996) Myelodysplastic syndromes and acute myeloid leukemia in connective tissue disease after single-agent chemotherapy. Am J Clin Pathol 106(5):676–679

    PubMed  CAS  Google Scholar 

  2. Lee KY, do Kim Y, Chang JY, Bang D (2008) Two cases of acute leukopenia induced by colchicine with concurrent immunosuppressants use in Behçet’s disease. Yonsei Med J 49(1):171–173

    Article  PubMed  Google Scholar 

  3. Fine LA, Hoffman LD, Hoffman MD (2007) Aphthous ulcerations associated with trisomy 8-positive myelodysplastic syndrome. J Am Acad Dermatol 57(2 Suppl):S38–S41

    Article  PubMed  Google Scholar 

  4. Ahn JK, Cha HS, Koh EM et al (2008) Behçet’s disease associated with bone marrow failure in Korean patients: clinical characteristics and the association of intestinal ulceration and trisomy 8. Rheumatology (Oxford) 47(8):1228–1230

    Article  CAS  Google Scholar 

  5. Lin YC, Liang TH, Chang HN, Lin JS, Lin HY (2008) Behçet’s disease associated with myelodysplastic syndrome. J Clin Rheumatol 14(3):169–174

    Article  PubMed  Google Scholar 

  6. Fujita H, Kiriyama M, Kawamura T et al (2002) Massive hemorrhage in a patient with intestinal Behçet’s disease: report of a case. Surg Today 32(4):378–382

    Article  PubMed  Google Scholar 

  7. Arimura K, Arima N, Matsushita K et al (2007) High incidence of morphological myelodysplasia and apoptotic bone marrow cells in Behçet’s disease. J Clin Immunol 27(2):145–151

    Article  PubMed  Google Scholar 

  8. Ohno E, Ohtsuka E, Watanabe K et al (1997) Behçet’s disease associated with myelodysplastic syndromes. A case report and a review of the literature. Cancer 79(2):262–268

    Article  PubMed  CAS  Google Scholar 

  9. Kimura S, Kuroda J, Akaogi T, Hayashi H, Kobayashi Y, Kondo M (2001) Trisomy 8 involved in myelodysplastic syndromes as a risk factor for intestinal ulcers and thrombosis – Behçet’s syndrome. Leuk Lymphoma 42(1–2):115–121

    Article  PubMed  CAS  Google Scholar 

  10. Kawabata H, Sawaki T, Kawanami T et al (2006) Myelodysplastic syndrome complicated with inflammatory intestinal ulcers: significance of trisomy 8. Intern Med 45(22):1309–1314

    Article  PubMed  Google Scholar 

  11. Eder L, Rozenbaum M, Boulman N et al (2005) Behçet’s disease, myelodysplastic syndrome, trisomy 8, gastroenterological involvement – an association. Clin Exp Rheumatol 23(4 Suppl 38):S91–S95

    PubMed  CAS  Google Scholar 

  12. Bangerter M, Griesshammer M, Tirpitz Cv et al (1999) Myelodysplastic syndrome with monosomy 7 after immunosuppressive therapy in Behçet’s disease. Scand J Rheumatol 28(2):117–119

    Article  PubMed  CAS  Google Scholar 

  13. Michels SD, McKenna RW, Arthur DC, Brunning RD (1985) Therapy-related acute myeloid leukemia and myelodysplastic syndrome: a clinical and morphologic study of 65 cases. Blood 65(6):1364–1372

    PubMed  CAS  Google Scholar 

  14. Nonami A, Takenaka K, Sumida C et al (2007) Successful treatment of myelodysplastic syndrome (MDS)-related intestinal Behçet’s disease by up-front cord blood transplantation. Intern Med 46(20):1753–1756

    Article  PubMed  Google Scholar 

  15. Tomonari A, Tojo A, Takahashi T et al (2004) Resolution of Behçet’s disease after HLA-mismatched unrelated cord blood transplantation for myelodysplastic syndrome. Ann Hematol 83(7):464–466

    Article  PubMed  Google Scholar 

  16. Yamato K (2003) Successful cord blood stem cell transplantation for myelodysplastic syndrome with Behçet’s disease. Int J Hematol 77(1):82–85

    Article  PubMed  Google Scholar 

  17. Demiroglu H, Dundar S (1997) Behçet’s disease and neutropenia. Int J Dermatol 36(7):557–559

    Article  PubMed  CAS  Google Scholar 

  18. Rogers RS 3rd (1997) Recurrent aphthous stomatitis: clinical characteristics and associated systemic disorders. Semin Cutan Med Surg 16(4):278–283

    Article  PubMed  Google Scholar 

  19. Leiferman KM, O’Duffy JD, Perry HO, Greipp PR, Giuliani ER, Gleich GJ (1982) Recurrent incapacitating mucosal ulcerations. A prodrome of the hypereosinophilic syndrome. JAMA 247(7):1018–1020

    Article  PubMed  CAS  Google Scholar 

  20. Budak-Alpdogan T, Demircay Z, Alpdogan O et al (1997) Behçet’s disease in patients with chronic myelogenous leukemia: possible role of interferon-alpha treatment in the occurrence of Behçet’s symptoms. Ann Hematol 74(1):45–48

    Article  PubMed  CAS  Google Scholar 

  21. Segawa F, Shimizu Y, Saito E, Kinoshita M (1995) Behçet’s disease induced by interferon therapy for chronic myelogenous leukemia. J Rheumatol 22(6):1183–1184

    PubMed  CAS  Google Scholar 

  22. Budak-Alpdogan T, Demircay Z, Alpdogan O et al (1998) Skin hyperreactivity of Behçet’s patients (pathergy reaction) is also positive in interferon alpha-treated chronic myeloid leukaemia patients, indicating similarly altered neutrophil functions in both disorders. Br J Rheumatol 37(11):1148–1151

    Article  PubMed  CAS  Google Scholar 

  23. Vaiopoulos G, Terpos E, Viniou N, Nodaros K, Rombos J, Loukopoulos D (2001) Behçet’s disease in a patient with chronic myelogenous leukemia under hydroxyurea treatment: a case report and review of the literature. Am J Hematol 66(1):57–58

    Article  PubMed  CAS  Google Scholar 

  24. Karincaoglu Y, Kaya E, Esrefoglu M, Aydogdu I (2003) Development of large genital ulcer due to hydroxyurea treatment in a patient with chronic myeloid leukemia and Behçet’s disease. Leuk Lymphoma 44(6):1063–1065

    Article  PubMed  CAS  Google Scholar 

  25. Cakmak SK, Gul U, Kilic A, Gonul M, Soylu S, Demirel O (2006) Behçet’s disease associated with chronic myelogenous leukemia and chronic graft-vs-host disease. Leuk Lymphoma 47(12):2674–2675

    Article  PubMed  Google Scholar 

  26. Kaklamani VG, Tzonou A, Kaklamanis PG (2005) Behçet’s disease associated with malignancies. Report of two cases and review of the literature. Clin Exp Rheumatol 23(4 Suppl 38):S35–S41

    PubMed  CAS  Google Scholar 

  27. Bakhshaee M, Ghasemi MM, Hatef MR, Talebmehr M, Shakeri MT (2007) Hearing loss in Behçet’s syndrome. Otolaryngol Head Neck Surg 137(3):439–442

    Article  PubMed  Google Scholar 

  28. Ak E, Harputluoglu U, Oghan F, Baykal B (2004) Behçet’s disease and hearing loss. Auris Nasus Larynx 31(1):29–33

    Article  PubMed  Google Scholar 

  29. Kulahli I, Balci K, Koseoglu E, Yuce I, Cagli S, Senturk M (2005) Audio-vestibular disturbances in Behçet’s patients: report of 62 cases. Hear Res 203(1–2):28–31

    Article  PubMed  Google Scholar 

  30. Bayazit YA, Yilmaz M, Gunduz B et al (2007) Distortion product otoacoustic emission findings in Behçet’s disease and rheumatoid arthritis. ORL J Otorhinolaryngol Relat Spec 69(4): 233–238

    Article  PubMed  Google Scholar 

  31. Evereklioglu C, Cokkeser Y, Doganay S, Er H, Kizilay A (2001) Audio-vestibular evaluation in patients with Behçet’s syndrome. J Laryngol Otol 115(9):704–708

    Article  PubMed  CAS  Google Scholar 

  32. Brama I, Fainaru M (1980) Inner ear involvement in Behçet’s disease. Arch Otolaryngol 106(4):215–217

    Article  PubMed  CAS  Google Scholar 

  33. Soylu L, Aydogan B, Soylu M, Ozsahinoglu C (1995) Hearing loss in Behçet’s disease. Ann Otol Rhinol Laryngol 104(11):864–867

    PubMed  CAS  Google Scholar 

  34. Gemignani G, Berrettini S, Bruschini P et al (1991) Hearing and vestibular disturbances in Behçet’s syndrome. Ann Otol Rhinol Laryngol 100(6):459–463

    PubMed  CAS  Google Scholar 

  35. Dagli M, Eryilmaz A, Tanrikulu S et al (2008) Evaluation of cochlear involvement by distortion product otoacoustic emission in Behçet’s disease. Auris Nasus Larynx 35(3):333–337

    Article  PubMed  Google Scholar 

  36. Muluk NB, Birol A (2007) Effects of Behçet’s disease on hearing thresholds and transient evoked otoacoustic emissions. J Otolaryngol 36(4):220–226

    Article  PubMed  Google Scholar 

  37. Pollak L, Luxon LM, Haskard DO (2001) Labyrinthine involvement in Behçet’s syndrome. J Laryngol Otol 115(7):522–529

    Article  PubMed  CAS  Google Scholar 

  38. Smith LN (1994) Unilateral sensorineural hearing loss in Behçet’s disease. Am J Otolaryngol 15(4):286–288

    Article  PubMed  CAS  Google Scholar 

  39. Choung YH, Cho MJ, Park K, Choi SJ, Shin YR, Lee ES (2006) Audio-vestibular disturbance in patients with Behçet’s disease. Laryngoscope 116(11):1987–1990

    Article  PubMed  Google Scholar 

  40. Igarashi Y, Watanabe Y, Aso S (1994) A case of Behçet’s disease with otologic symptoms. ORL J Otorhinolaryngol Relat Spec 56(5):295–298

    Article  PubMed  CAS  Google Scholar 

  41. Adler YD, Jovanovic S, Jivanjee A, Krause L, Zouboulis CC (2002) Adamantiades–Behçet’s disease with inner ear involvement. Clin Exp Rheumatol 20(4 Suppl 26):S40–S42

    PubMed  CAS  Google Scholar 

  42. Elidan J, Levi H, Cohen E, BenEzra D (1991) Effect of cyclosporine A on the hearing loss in Behçet’s disease. Ann Otol Rhinol Laryngol 100(6):464–468

    PubMed  CAS  Google Scholar 

  43. Quaranta N, Bartoli R, Giagnotti F, Di Cuonzo F, Quaranta A (2002) Cochlear implants in systemic autoimmune vasculitis syndromes. Acta Otolaryngol Suppl 548:44–48

    Article  PubMed  Google Scholar 

  44. Szilvassy J, Czigner J, Jori J et al (1998) Cochlear implantation of a Hungarian deaf and blind patient with discharging ears suffering from Behçet’s disease. J Laryngol Otol 112(2):169–171

    Article  PubMed  CAS  Google Scholar 

  45. Barna BP, Hughes GB (1988) Autoimmunity and otologic disease: clinical and experimental aspects. Clin Lab Med 8(2):385–398

    PubMed  CAS  Google Scholar 

  46. Akpolat T, Dilek M, Aksu K, Keser G, Toprak O, Cirit M, Oğuz Y, Taşkapan H, Adibelli Z, Akar H, Tokgöz B, Arici M, Celiker H, Diri B, Akpolat I (2008) Renal Behçet’s disease: an update. Semin Arthritis Rheum 38:241–248

    Article  PubMed  Google Scholar 

  47. Rosenthal T, Weiss P, Gafni J (1978) Renal involvement in Behçet’s syndrome. Arch Intern Med 138:1122–1124

    Article  PubMed  CAS  Google Scholar 

  48. Kaklamani VG, Nikolopoulou N, Sotsiou F, Billis A, Kaklamanis P (2001) Renal involvement in Adamantiades–Behçet’s disease. Case report and review of the literature. Clin Exp Rheumatol 19(5 Suppl 24):S55–S58

    PubMed  CAS  Google Scholar 

  49. Akpolat T, Akkoyunlu M, Akpolat I, Dilek M, Odabas AR, Ozen S (2002) Renal Behçet’s disease: a cumulative analysis. Semin Arthritis Rheum 31:317–337

    Article  PubMed  Google Scholar 

  50. Akpolat T, Diri B, Oğuz Y, Yilmaz E, Yavuz M, Dilek M (2003) Behçet’s disease and renal failure. Nephrol Dial Transplant 18:888–891

    Article  PubMed  CAS  Google Scholar 

  51. Akpolat T, Yilmaz E, Akpolat I, Dilek M, Karagoz F, Balci B, Ozen S (2002) Amyloidosis in Behçet’s disease and familial Mediterranean fever. Rheumatology (Oxford) 41:592–593

    Article  CAS  Google Scholar 

  52. Dilsen N, Konice M, Aral O, Erbengi T, Uysal V, Kocak N, Ozdogan E (1988) Behçet’s disease associated with amyloidosis in Turkey and in the world. Ann Rheum Dis 47:157–163

    Article  PubMed  Google Scholar 

  53. Yurdakul S, Tüzüner N, Yurdakul I, Hamuryudan V, Yazici H (1990) Amyloidosis in Behçet’s syndrome. Arthritis Rheum 33:1586–1589

    Article  PubMed  CAS  Google Scholar 

  54. Melikoglu M, Altiparmak MR, Fresko I, Tunc R, Yurdakul S, Hamuryudan V, Yazici H (2001) A reappraisal of amyloidosis in Behçet’s syndrome. Rheumatology (Oxford) 40:212–215

    Article  Google Scholar 

  55. Chiba M, Inoue Y, Arakawa H, Masamune O, Ohkubo M (1987) Behçet’s disease associated with amyloidosis. Gastroenterol Jpn 22:487–495

    PubMed  CAS  Google Scholar 

  56. Rosenthal T, Bank H, Aladjem M, David R, Gafni J (1975) Systemic amyloidosis in Behçet’s disease. Ann Intern Med 83:220–223

    PubMed  CAS  Google Scholar 

  57. Utku U, Dilek M, Akpolat I, Bedir A, Akpolat T (2007) SAA1 alpha/alpha alleles in Behçet’s disease related amyloidosis. Clin Rheumatol 26:927–929

    Article  PubMed  Google Scholar 

  58. Tasdemir I, Sivri B, Turgan C, Emri S, Yasavul U, Caglar S (1989) The expanding spectrum of a disease. Behçet’s disease associated with amyloidosis. Nephron 52:154–157

    Article  PubMed  CAS  Google Scholar 

  59. Altiparmak MR, Tanverdi M, Pamuk ON, Tunc R, Hamuryudan V (2002) Glomerulonephritis in Behçet’s disease: report of seven cases and review of the literature. Clin Rheumatol 21:14–18

    Article  PubMed  CAS  Google Scholar 

  60. Gürler A, Boyvat A, Türsen U (1997) Clinical manifestations of Behçet’s disease: an analysis of 2147 patients. Yonsei Med J 38:423–427

    PubMed  Google Scholar 

  61. Finucane P, Doyle CT, Ferriss JB, Molloy M, Murnaghan D (1985) Behçet’s syndrome with myositis and glomerulonephritis. Br J Rheumatol 24:372–375

    Article  PubMed  CAS  Google Scholar 

  62. Tietjen DP, Moore WJ (1990) Treatment of rapidly progressive glomerulonephritis due to Behçet’s syndrome with intravenous cyclophosphamide. Nephron 55:69–73

    Article  PubMed  CAS  Google Scholar 

  63. Fukuda Y, Hayashi H (1982) Renal involvement in Behçet’s disease. Ensyo 2:545–548

    Article  Google Scholar 

  64. Sugiyama E, Suzuki H, Akagawa N, Yamashita N, Yano S, Iida H, Kitagawa M (1984) [Behçet’s disease associated with IgA nephropathy: report of a case]. Nippon Naika Gakkai Zasshi 73:1818–1822

    Article  PubMed  CAS  Google Scholar 

  65. Sudo J, Matsubara T, Iwai H, Ueda Y, Kameda S, Iwata T et al (1987) IgA nephropathy developed in a patient with Behçet’s disease. Kidney dial 22:893–897

    Google Scholar 

  66. Donnelly S, Jothy S, Barré P (1989) Crescentic glomerulonephritis in Behçet’s syndrome – results of therapy and review of the literature. Clin Nephrol 31:213–218

    PubMed  CAS  Google Scholar 

  67. Hamuryudan V, Yurdakul S, Kural AR, Ince U, Yazici H (1991) Diffuse proliferative glomerulonephritis in Behçet’s syndrome. Br J Rheumatol 30:63–64

    Article  PubMed  CAS  Google Scholar 

  68. El Ramahi KM, Al Dalaan A, Al Shaikh A, Al Meshari K, Akhtar M (1998) Renal involvement in Behçet’s disease: review of 9 cases. J Rheumatol 25:2254–2260

    PubMed  Google Scholar 

  69. Koç Y, Güllü I, Akpek G, Akpolat T, Kansu E, Kiraz S, Batman F, Kansu T, Balkanci F, Akkaya S et al (1992) Vascular involvement in Behçet’s disease. J Rheumatol 19:402–410

    PubMed  Google Scholar 

  70. Sueyoshi E, Sakamoto I, Hayashi N, Fukuda T, Matsunaga N, Hayashi K, Inoue K (1996) Ruptured renal artery aneurysm due to Behçet’s disease. Abdom Imaging 21:166–167

    Article  PubMed  CAS  Google Scholar 

  71. Sherif A, Stewart P, Mendes DM (1992) The repetitive vascular catastrophes of Behçet’s disease: a case report with review of the literature. Ann Vasc Surg 6:85–89

    Article  PubMed  CAS  Google Scholar 

  72. Han K, Siegel R, Pantuck AJ, Gazi MA, Burno DK, Weiss RE (1999) Behçet’s syndrome with left ventricular aneurysm and ruptured renal artery pseudoaneurysm. Urology 54:162

    Article  PubMed  CAS  Google Scholar 

  73. Fukuda T, Hayashi K, Sakamoto I, Mori M (1995) Acute renal infarction caused by Behçet’s disease. Abdom Imaging 20:264–266

    Article  PubMed  CAS  Google Scholar 

  74. Malik GH, Sirwal IA, Pandit KA (1989) Behçet’s syndrome associated with minimal change glomerulonephritis and renal vein thrombosis. Nephron 52:87–89

    Article  PubMed  CAS  Google Scholar 

  75. Angotti C, D’Cruz DP, Abbs IC, Hughes GR (2003) Renal microinfarction in Behçet’s disease. Rheumatology (Oxford) 42:1416–1417

    Article  CAS  Google Scholar 

  76. Planer D, Verstandig A, Chajek-Shaul T (2001) Transcatheter embolization of renal artery aneurysm in Behçet’s disease. Vasc Med 6:109–112

    PubMed  CAS  Google Scholar 

  77. Apaydin S, Erek E, Ulkü U, Hamuryudan V, Yazici H, Sariyar M (1999) A successful renal transplantation in Behçet’s syndrome. Ann Rheum Dis 58:719

    Article  PubMed  CAS  Google Scholar 

  78. Kirkali Z, Yigitbasi O, Sasmaz R (1991) Urological aspects of Behçet’s disease. Br J Urol 67(6):638–639

    Article  PubMed  CAS  Google Scholar 

  79. Sharquie KE, Al-Rawi Z (1987) Epididymo-orchitis in Behçets disease. Br J Rheumatol 26(6):468–469

    Article  PubMed  CAS  Google Scholar 

  80. Kaklamani VG, Vaiopoulos G, Markomichelakis N, Kaklamanis P (2000) Recurrent epididymo-orchitis in patients with Behçet’s disease. J Urol 163(2):487–489

    Article  PubMed  CAS  Google Scholar 

  81. Callejas-Rubio JL, Ortego N, Diez A, Castro M, De La Higuera J (1998) Recurrent epididymo-orchitis secondary to Behçets disease. J Urol 160(2):496

    Article  PubMed  CAS  Google Scholar 

  82. Pannek J, Haupt G (1997) Orchitis due to vasculitis in autoimmune diseases. Scand J Rheumatol 26(3):151–154

    Article  PubMed  CAS  Google Scholar 

  83. Eilber KS, Freedland SJ, Rajfer J (2001) Polyarteritis nodosa presenting as hematuria and a testicular mass. J Urol 166(2):624

    Article  PubMed  CAS  Google Scholar 

  84. Mayer DF, Matteson EL (2004) Testicular involvement in rheumatoid vasculitis. Clin Exp Rheumatol 22(6 Suppl 36):S62–S64

    PubMed  CAS  Google Scholar 

  85. Joudi FN, Austin JC, Vogelgesang SA, Jensen CS (2004) Isolated testicular vasculitis presenting as a tumor-like lesion. J Urol 171(2 Pt 1):799

    Article  PubMed  Google Scholar 

  86. Ek L, Hedfors E (1993) Behçet’s disease: a review and a report of 12 cases from Sweden. Acta Derm Venereol 73(4):251–254

    PubMed  CAS  Google Scholar 

  87. Zouboulis CC, Kotter I, Djawari D et al (1997) Epidemiological features of Adamantiades–Behçet’s disease in Germany and in Europe. Yonsei Med J 38(6):411–422

    PubMed  CAS  Google Scholar 

  88. Fuse H, Ohkawa M, Yamaguchi K, Hirata A, Matsubara F (1995) Cryptococcal prostatitis in a patient with Behçet’s disease treated with fluconazole. Mycopathologia 130(3):147–150

    Article  PubMed  CAS  Google Scholar 

  89. Chajek T, Fainaru M (1975) Behçet’s disease. Report of 41 cases and a review of the literature. Medicine (Baltimore) 54(3):179–196

    Article  CAS  Google Scholar 

  90. Carswell GF (1976) A case of Behçet’s disease involving the bladder. Br J Urol 48(3): 199–202

    Article  PubMed  CAS  Google Scholar 

  91. McDonald GS, Gad-Al-Rab J (1980) Behçet’s disease with endocarditis and the Budd–Chiari syndrome. J Clin Pathol 33(7):660–669

    Article  PubMed  CAS  Google Scholar 

  92. Ates A, Aydintug OT, Duzgun N, Yaman O, Sancak T, Omur ND (2004) Behçet’s disease presenting as deep venous thrombosis and priapism. Clin Exp Rheumatol 22(1):107–109

    PubMed  CAS  Google Scholar 

  93. Moalla M, Gabsi M, el Ouakdi M, Zmerli S, Ben Ayed H (1990) Behçet disease and priapism. J Rheumatol 17(4):570–571

    PubMed  CAS  Google Scholar 

  94. Erdogru T, Kocak T, Serdaroglu P, Kadioglu A, Tellaloglu S (1999) Evaluation and therapeutic approaches of voiding and erectile dysfunction in neurological Behçet’s syndrome. J Urol 162(1):147–153

    Article  PubMed  CAS  Google Scholar 

  95. Kone-Paut I, Yurdakul S, Bahabri SA et al (1998) Clinical features of Behçet’s disease in children: an international collaborative study of 86 cases. J Pediatr 132(4):721–725

    Article  PubMed  CAS  Google Scholar 

  96. Shaefei N, Shahram F, Davatchi F et al (1998) Comparison of juvenile with adult Behçet’s disease (A). Arthritis Rheum 41(S124)

    Google Scholar 

  97. Pektas A, Devrim I, Besbas N, Bilginer Y, Cengiz AB, Ozen S (2008) A child with Behçet’s disease presenting with a spectrum of inflammatory manifestations including epididymoorchitis. Turk J Pediatr 50(1):78–80

    PubMed  Google Scholar 

  98. Lakhanpal S, Tani K, Lie JT, Katoh K, Ishigatsubo Y, Ohokubo T (1985) Pathologic features of Behçet’s syndrome: a review of Japanese autopsy registry data. Hum Pathol 16(8):790–795

    Article  PubMed  CAS  Google Scholar 

  99. Dokmeci F, Cengiz B, Ortac F (1996) Pelvic mass in a patient with Behçet’s disease. Obstet Gynecol 87(5 Pt 2):881

    PubMed  CAS  Google Scholar 

  100. Cetinel B, Obek C, Solok V, Yaycioglu O, Yazici H (1998) Urologic screening for men with Behçet’s syndrome. Urology 52(5):863–865

    Article  PubMed  CAS  Google Scholar 

  101. Monteiro H, Nogueira R, de Carvalho H (1995) Behçet’s syndrome and vesicovaginal fistula: an unusual complication. J Urol 153(2):407–408

    Article  PubMed  CAS  Google Scholar 

  102. Aoki T, Tanaka T, Akifuji Y et al (2000) Beneficial effects of interferon-alpha in a case with Behçet’s disease. Intern Med 39(8):667–669

    Article  PubMed  CAS  Google Scholar 

  103. Saito M, Miyagawa I (2000) Bladder dysfunction due to Behçet’s disease. Urol Int 65(1): 40–42

    Article  PubMed  CAS  Google Scholar 

  104. Karandreas N, Tsivgoulis G, Zambelis T et al (2007) Urinary frequency in a case of Neuro-Behçet disease involving the brainstem - clinical, electrophysiological and urodynamic features. Clin Neurol Neurosurg 109(9):806–810

    Article  PubMed  Google Scholar 

  105. Akman-Demir G, Serdaroglu P, Tasci B (1999) Clinical patterns of neurological involvement in Behçet’s disease: evaluation of 200 patients. The Neuro-Behçet Study Group. Brain 122(Pt 11):2171–2182

    Article  PubMed  Google Scholar 

  106. Yesilot N, Mutlu M, Gungor O, Baykal B, Serdaroglu P, Akman-Demir G (2007) Clinical characteristics and course of spinal cord involvement in Behçet’s disease. Eur J Neurol 14(7):729–737

    Article  PubMed  CAS  Google Scholar 

  107. Szymajda A, Eledrisi MS, Patel R, Chaljub G, Cepeda E, Kaushik P (2003) Diabetes insipidus as a consequence of neurologic involvement in Behçet’s syndrome. Endocr Pract 9(1): 33–35

    PubMed  Google Scholar 

  108. Jin-No M, Fujii T, Jin-No Y, Kamiya Y, Okada M, Kawaguchi M (1999) Central diabetes insipidus with Behçet’s disease. Intern Med 38(12):995–999

    Article  PubMed  CAS  Google Scholar 

  109. Cetinel B, Akpinar H, Tufek I, Uygun N, Solok V, Yazici H (1999) Bladder involvement in Behçet’s syndrome. J Urol 161(1):52–56

    Article  PubMed  CAS  Google Scholar 

  110. Theodorou C, Floratos D, Hatzinicolaou P, Vaiopoulos G (1999) Neurogenic bladder dysfunction due to Behçet’s disease. Int J Urol 6(8):423–425

    Article  PubMed  CAS  Google Scholar 

  111. Celik I, Altundag K, Erman M, Baltali E (1999) Cyclophosphamide-associated carcinoma of the urinary bladder in Behçet’s disease. Nephron 81(2):239

    Article  PubMed  CAS  Google Scholar 

  112. Baltaci S, Gogus C, Karamursel T, Tulunay O (2003) Invasive bladder carcinoma in a patient with Behçet’s disease. Int J Urol 10(12):669–671

    Article  PubMed  Google Scholar 

  113. Sarica K, Suzer O, Gurler A, Baltaci S, Ozdiler E, Dincel C (1995) Urological evaluation of Behçet patients and the effect of colchicine on fertility. Eur Urol 27(1):39–42

    PubMed  CAS  Google Scholar 

  114. Korkmaz C, Ozcan A, Akcar N (2005) Increased frequency of ultrasonographic findings suggestive of renal stones in patients with ankylosing spondylitis. Clin Exp Rheumatol 23(3):389–392

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Division of Rheumatology, Cerrahpasa Medical Faculty, Istanbul, Turkey

    İzzet Fresko

Authors
  1. Kenneth T. Calamia
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. İzzet Fresko
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to İzzet Fresko .

Editor information

Editors and Affiliations

  1. Hospital for Joint Diseases, Behçet's Syndrome Center, NYU Medical Center, East 20th Street 246, New York, 10003, New York, USA

    Yusuf Yazıcı

  2. , Department of Medicine, University of Istanbul, Istanbul, 34452, Turkey

    Hasan Yazıcı

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Calamia, K.T., Fresko, İ. (2010). Miscellaneous Manifestations of Behçet’s Disease. In: Yazıcı, Y., Yazıcı, H. (eds) Behçet’s Syndrome. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5641-5_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-4419-5641-5_11

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-5640-8

  • Online ISBN: 978-1-4419-5641-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation