Bridging Innate NK Cell Functions with Adaptive Immunity

  • Emanuela Marcenaro
  • Simona Carlomagno
  • Silvia Pesce
  • Alessandro Moretta
  • Simona Sivori
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 780)


Killer Ig-like receptors (KIRs) are major human NK receptors displaying either inhibitory or activating functions which recognize allotypic determinants of HLA-class I molecules. Surprisingly, NK cell treatment with CpG-ODN (TLR9 ligands) results in selective down-modulation of KIR3DL2, its co-internalization with CpG-ODN and its translocation to TLR9-rich early endosomes. This novel KIR-associated function may offer clues to better understand the possible role of certain KIRs and also emphasizes the involvement of NK cells in the course of microbial infections. NK cells are involved not only in innate immune responses against viruses and tumors but also participate in the complex network of cell-to cell interaction that leads to the development of adaptive immune responses. In this context the interaction of NK cells with DC appears to play a crucial role in the acquisition of CCR7, a chemokine receptor that enables NK cells to migrate towards lymph nodes in response to CCL19 and/or CCL21. Analysis of NK cell clones revealed that KIR-mismatched but not KIR-matched NK cells acquire CCR7. These data have important implications in haploidentical haematopoietic stem cell transplantation (HSCT), in which KIR-mismatched NK cells may acquire the ability to migrate to secondary lymphoid compartments (SLCs), where they can kill recipient’s antigen presenting cells (APCs) and T cells thus preventing graft versus host (and host vs. graft) reactions.


Natural Killer Natural Killer Cell Human Natural Killer Cell Natural Killer Cell Function Natural Killer Cell Subset 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by grants awarded by Associazione Italiana per la Ricerca sul Cancro (A.I.R.C.): MFAG project n. 6383 (S.S.) and IG project n. 10643 (A.M.); Istituto Superiore di Sanità (I.S.S.), agreement n. 40G.41; Ministero della Sanità, Ministero dell’Istruzione, dell’Università e della Ricerca Scientifica e Tecnologica (MIUR-PRIN 2006/project 2006061378_003; MIUR-FIRB 2003 project RBLA039LSF_001) and Progetto di Ricerca di Ateneo 2008 dell’Università di Genova, project E.M.


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Copyright information

© Springer Science+Businees Media, LLC 2011

Authors and Affiliations

  • Emanuela Marcenaro
  • Simona Carlomagno
  • Silvia Pesce
  • Alessandro Moretta
    • 1
    • 2
  • Simona Sivori
  1. 1.Dipartimento di Medicina Sperimentale-sezione IstologiaUniversità degli Studi di GenovaGenovaItaly
  2. 2.Centro di Eccellenza per le Ricerche BiomedicheUniversità degli Studi di GenovaGenovaItaly

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