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KIR/HLA: Genetic Clues for a Role of NK Cells in the Control of HIV

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Crossroads between Innate and Adaptive Immunity III

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 780))

Abstract

Early events following HIV infections determine the course of disease progression. Mounting evidence suggests that antiviral immune responses induced soon after infection, prior to the induction of adaptive immune responses, are key to early control of viral infection. Among the early innate immune effector cells, natural killer (NK) cells represent a unique subset of lymphoctyes that do not express an antigen specific receptor. Rather, these cells integrate signals from an arsenal of non-specific inhibitory and activating receptors that are expressed on their cell surface. As such, these cells are classified as cells of the innate immune system, and they are able to lyse certain tumor targets and infected cells without the need for prior antigen sensitization. Over the past decade, accumulating evidence suggests that these innate lymphocytes may not be as innate as once believed, but that individual NK cell clones may show some target cell specificity, and play a critical early role following infection with HIV.

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Authors and Affiliations

  1. Ragon Institute of MGH, MIT, and Harvard, 149 13th ST., Room 6618b, Charlestown, MA, 02129, USA

    Galit Alter

Authors
  1. Lena Fadda
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  2. Galit Alter
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Correspondence to Galit Alter .

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Editors and Affiliations

  1. Emory Vaccine Center &, Yerkes National Primate Research Center, Emory University, Gatewood Rd. 954, Atlanta, 30329, Georgia, USA

    Bali Pulendran

  2. College of Medicine, Department Microbiology & Immunology, Drexel University, Queen Lane 2900, Philadelphia, 19129, Pennsylvania, USA

    Peter D. Katsikis

  3. , Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immun, Athena Circle 9420, La Jolla, 92037, USA

    Stephen P. Schoenberger

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Fadda, L., Alter, G. (2011). KIR/HLA: Genetic Clues for a Role of NK Cells in the Control of HIV. In: Pulendran, B., Katsikis, P., Schoenberger, S. (eds) Crossroads between Innate and Adaptive Immunity III. Advances in Experimental Medicine and Biology, vol 780. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5632-3_3

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