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Is Transcription the Dominant Force During Dynamic Changes in Gene Expression?

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Crossroads between Innate and Adaptive Immunity III

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 780))

Abstract

Dynamic changes in gene expression punctuate lymphocyte development and are a characteristic of lymphocyte activation. A prevailing view has been that these changes are driven by DNA transcription factors, which are the dominant force in gene expression. Accumulating evidence is challenging this DNA centric view and has highlighted the prevalence and dynamic nature of RNA handling mechanisms. Alternative splicing and differential polyadenylation appear to be more widespread than first thought. Changes in mRNA decay rates also affect the abundance of transcripts and this mechanism may contribute significantly to gene expression. Additional RNA handling mechanisms that control the intracellular localization of mRNA and association with translating ribosomes are also important. Thus, gene expression is regulated through the coordination of transcriptional and post-transcriptional mechanisms. Developing a more “RNA centric” view of gene expression will allow a more systematic understanding of how gene expression and cell function are integrated.

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Acknowledgements

I thank all of my colleagues for their contributions to our work on post-transcriptional control. Work in the author’s laboratory is supported by a Senior Non-clinical Fellowship by the Medical Research Council and by the Biotechnology and Biological Sciences Research Council.

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Authors and Affiliations

  1. Laboratory of Lymphocyte Signaling and Development, The Babraham Institute, Babraham, Cambridge, CB22 3AT, UK

    Martin Turner

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  1. Martin Turner
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Correspondence to Martin Turner .

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Editors and Affiliations

  1. Emory Vaccine Center &, Yerkes National Primate Research Center, Emory University, Gatewood Rd. 954, Atlanta, 30329, Georgia, USA

    Bali Pulendran

  2. College of Medicine, Department Microbiology & Immunology, Drexel University, Queen Lane 2900, Philadelphia, 19129, Pennsylvania, USA

    Peter D. Katsikis

  3. , Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immun, Athena Circle 9420, La Jolla, 92037, USA

    Stephen P. Schoenberger

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Turner, M. (2011). Is Transcription the Dominant Force During Dynamic Changes in Gene Expression?. In: Pulendran, B., Katsikis, P., Schoenberger, S. (eds) Crossroads between Innate and Adaptive Immunity III. Advances in Experimental Medicine and Biology, vol 780. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5632-3_1

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