Abstract
The most common route of drug administration is the oral route. As such, an understanding of factors that influence oral absorption is important. For a drug to enter the systemic circulation following oral administration, the drug must first dissolve, cross the intestinal membrane, and pass through the liver. This chapter gives a general overview of oral absorption and include concepts such as first-pass metabolism.
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Abbreviations
- BCS:
-
Biopharmaceutics classification system
- BDDCS:
-
Biopharmaceutics drug disposition classification system
- AUCPO :
-
AUC following an oral dose
- AUCIV :
-
AUC following an intravenous dose
- E g :
-
Extraction ratio of the gut
- E h :
-
Extraction ratio of the liver
- F :
-
Bioavailability
- F a :
-
Fraction of drug absorbed from the intestinal lumen
- F g :
-
Fraction of orally administered drug escaping intestinal metabolism
- F h :
-
Fraction of orally administered drug escaping hepatic metabolism/elimination
- MAD:
-
Maximum absorbable dose
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Khojasteh, S.C., Wong, H., Hop, C.E.C.A. (2011). Oral Absorption. In: Drug Metabolism and Pharmacokinetics Quick Guide. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-5629-3_3
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DOI: https://doi.org/10.1007/978-1-4419-5629-3_3
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