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Oral Absorption

  • Siamak Cyrus Khojasteh
  • Harvey Wong
  • Cornelis E. C. A. Hop
Chapter

Abstract

The most common route of drug administration is the oral route. As such, an understanding of factors that influence oral absorption is important. For a drug to enter the systemic circulation following oral administration, the drug must first dissolve, cross the intestinal membrane, and pass through the liver. This chapter gives a general overview of oral absorption and include concepts such as first-pass metabolism.

Keywords

Extraction Ratio Oral Absorption Biopharmaceutics Classification System Permeation Rate Absorption Rate Constant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

List of Abbreviations

BCS

Biopharmaceutics classification system

BDDCS

Biopharmaceutics drug disposition classification system

AUCPO

AUC following an oral dose

AUCIV

AUC following an intravenous dose

Eg

Extraction ratio of the gut

Eh

Extraction ratio of the liver

F

Bioavailability

Fa

Fraction of drug absorbed from the intestinal lumen

Fg

Fraction of orally administered drug escaping intestinal metabolism

Fh

Fraction of orally administered drug escaping hepatic metabolism/elimination

MAD

Maximum absorbable dose

References

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Additional Readings

  1. Amidon GL, Lennernas H, Shah VP et al (1995) A theoretical basis for a biopharmaceutical drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm Res 12:413–420PubMedCrossRefGoogle Scholar
  2. Ehrhardt C, Kim KJ (2008) Drug absorption studies: in situ, in vitro and in silico models. Springer Science and Business Media, LLC, New York, NYGoogle Scholar
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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Siamak Cyrus Khojasteh
    • 1
  • Harvey Wong
    • 1
  • Cornelis E. C. A. Hop
    • 1
  1. 1.Genentech, Inc.San FranciscoUSA

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