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Gonadotropin-Releasing Hormone Agonists in Fertility Preservation

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Fertility Preservation

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Abstract

Fertility preservation in females diagnosed with cancer has become an important area of investigation due to increasing cancer survival rates combined with delayed childbearing. Initial studies using gonadotropin-releasing hormone (GnRH) agonist cotreatment with chemotherapy demonstrated promising results for fertility preservation. If this protective effect of GnRH agonists is confirmed by the ongoing prospective randomized clinical trials, GnRH agonist cotreatment may become valuable option for fertility preservation in reproductive-age women undergoing chemotherapy. Thus, ovarian protection may enable the preservation of future fertility in survivors and, in addition, prevent other adverse effects of premature menopause, such as bone density loss, sexual dysfunction, and vasomotor symptoms.

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Authors and Affiliations

  1. Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA

    Hakan Cakmak MD (Resident)

  2. Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06510, USA

    Emre Seli MD (Associate Professor, Associate Director for Research)

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  1. Hakan Cakmak MD
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  1. School of Medicine, Department of Obstetrics, Gynecology, Yale University, Cedar St. 333, New Haven, 06510, Connecticut, USA

    Emre Seli

  2. , Director, Center for Reproductive, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, 44195, Ohio, USA

    Ashok Agarwal

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Cakmak, H., Seli, E. (2012). Gonadotropin-Releasing Hormone Agonists in Fertility Preservation. In: Seli, E., Agarwal, A. (eds) Fertility Preservation. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1783-6_13

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