Management of Bleeding Peptic Ulcer Disease

  • James C. Padussis
  • Theodore N. Pappas


Peptic ulcers are defects in the gastrointestinal mucosa that extend through the muscularis mucosae. They persist as a function of the acid or peptic activity in gastric juice. The natural history of peptic ulcer disease (PUD) ranges from resolution without intervention to the development of complications with potential for significant morbidity and mortality, such as bleeding and perforation. Peptic ulcer disease is an important cause of morbidity and health-care costs. Estimates of expenditures related to work loss, hospitalization, and outpatient care are $5.65 billion per year in the United States [1].


Peptic Ulcer Peptic Ulcer Disease Fibrin Sealant Endoscopic Therapy Transcatheter Embolization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.General Surgery Residency Training ProgramDuke University Medical CenterDurhamUSA
  2. 2.Department of SurgeryDuke University Medical CenterDurhamUSA

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