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Diabetes Mellitus and Transplantation: Risks for Post-transplant Diabetes

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Abstract

New onset diabetes mellitus after transplantation (NODAT) is a serious and frequently observed complication following solid organ transplantation. Kidney transplant recipients who develop NODAT are at increased risk of fatal and non-fatal cardiovascular events and other adverse outcomes including infection, reduced patient survival, graft rejection, and accelerated graft loss compared with those who do not develop diabetes. Identification of high-risk patients and implementation of measures to reduce the development of NODAT may improve long-term patient and graft outcome. The following chapter presents an overview of the literature on the current diagnostic criteria for NODAT, its incidence after solid organ transplantation, suggested risk factors, and potential pathogenic mechanisms. The impact of NODAT on patient and allograft outcomes and suggested guidelines for early identification and management of NODAT will also be discussed.

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Authors and Affiliations

  1. Division of Nephrology, Department of Medicine, Kidney and Pancreas Transplant Program, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    Phuong-Thu T. Pham MD & Alan H. Wilkinson MD, FRCP

  2. David Geffen School of Medicine at UCLA, Sepulveda VA, Internal Medicine, North Hills, CA, USA

    Phuong-Mai T. Pham MD

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  1. Phuong-Thu T. Pham MD
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  2. Phuong-Mai T. Pham MD
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  3. Alan H. Wilkinson MD, FRCP
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Correspondence to Phuong-Thu T. Pham MD .

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Editors and Affiliations

  1. Scripps Research Institute, N.Torrey Pines Rd. 10550, La Jolla, 92037, USA

    Dianne B. McKay

  2. Division of Transplantation, Sharp Memorial Hospital, Frost Street 7910, San Diego, 92123, USA

    Steven M. Steinberg

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Pham, PT.T., Pham, PM.T., Wilkinson, A.H. (2010). Diabetes Mellitus and Transplantation: Risks for Post-transplant Diabetes. In: McKay, D., Steinberg, S. (eds) Kidney Transplantation: A Guide to the Care of Kidney Transplant Recipients. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-1690-7_16

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  • DOI: https://doi.org/10.1007/978-1-4419-1690-7_16

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