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SuperMEN1 pp 87–95Cite as

Role of Menin in Neuroendocrine Tumorigenesis

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 668))

Abstract

The menin protein encoded by the MEN1 tumor suppressor gene is ubiquitously expressed and highly conserved evolutionarily. The combination of findings from current in vitro and in vivo studies has not yielded a comprehensive understanding of the mechanisms of menin’s tumor suppressor activity or the specific role for menin in endocrine tumorigenesis, although its diverse interactions suggest possible pivotal roles in transcriptional regulation, DNA processing and repair and cytoskeletal integrity. This manuscript summarizes recent research findings including studies of global gene expression in MEN1-associared neuroendocrine tumors and pivotal changes in intracellular signaling pathways associated with neuroendocrine tumorigenesis. Finally, the clinical applications provided by the understanding of the effects of MEN1 gene mutations on neuroendocrine tumor development in patients with this familial cancer syndrome are discussed.

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Author information

Authors and Affiliations

  1. Department of Surgery Division of Surgical Oncology, Scott and White Memorial Hospital Clinic, Texas A&M University System Health Sciences Center College of Medicine, 2401 S. 31st Street, Temple, Texas, 76508, USA

    Terry C. Lairmore

  2. Section of Endocrine Surgery Department of Surgery, The University ofWisconsin University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin, USA

    Herbert Chen (Chief of Endocrine Surgery)

Authors
  1. Terry C. Lairmore
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  2. Herbert Chen
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Editors and Affiliations

  1. 2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary

    Katalin Balogh MD, PhD

  2. Hungarian Academy of Sciences Molecular Medicine Research Group and 2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary

    Attila Patocs MD, MSc, PhD

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Lairmore, T.C., Chen, H. (2009). Role of Menin in Neuroendocrine Tumorigenesis. In: Balogh, K., Patocs, A. (eds) SuperMEN1. Advances in Experimental Medicine and Biology, vol 668. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1664-8_9

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