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Adrenal Tumors in MEN1 Syndrome and the Role of Menin in Adrenal Tumorigenesis

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SuperMEN1

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 668))

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Abstract

Most of the adrenal tumors are benign adrenocortical adenoma (AA)and pheochromocytomas (Pheo) originatingfrom the adrenal medulla, but rarely malignant adrenocortical carcinomas (ACC) can be also found. Adrenal tumors causinghormonal overproduction such as aldosterone-producing and cortisol-producingtumors are also rare, whereas nonhyperfunctioning adenomas occur more frequently.1 During the last decades an extensive use of advanced imaging techniques (computer tomography, magnetic resonance imaging, endoscopic ultrasound) has led to an increased incidence of accidentally discovered adrenal masses, Le., incidentalomas.2–4 The prevalence of incidentalomas is up to 9% of all autopsy cases. The majority of these tumors are hormonally inactive and are of adrenocortical origin, but pheochromocytomas and hormonally active adrenocortical tumors associated with the development of Cushing’s syndrome or primary aldosteronism can also be found in some patient.1,4

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Authors and Affiliations

  1. Hungarian Academy of Sciences Molecular Medicine Research Group and 2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Central Isotope Laboratory Semmelweis University, 1088, Budapest, Szentkirályi u. 46, Hungary

    Attila Patocs

  2. 2nd Department of Medicine Faculty of Medicine, Semmelweis University, Budapest, Hungary

    Katalin Balogh & Karoly Racz

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  1. Attila Patocs
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  2. Katalin Balogh
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Editors and Affiliations

  1. 2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary

    Katalin Balogh MD, PhD

  2. Hungarian Academy of Sciences Molecular Medicine Research Group and 2nd Department of Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary

    Attila Patocs MD, MSc, PhD

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© 2009 Landes Bioscience and Springer Science+Business Media

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Patocs, A., Balogh, K., Racz, K. (2009). Adrenal Tumors in MEN1 Syndrome and the Role of Menin in Adrenal Tumorigenesis. In: Balogh, K., Patocs, A. (eds) SuperMEN1. Advances in Experimental Medicine and Biology, vol 668. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1664-8_10

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