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Pediatric Chronic Pain

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Handbook of Pain and Palliative Care

Abstract

Pediatric chronic pain has extensive and frequently sustained detrimental effects on the health, development and quality of life of young people, with an attendant adverse impact on all those invested in their well-being. It has long been appreciated that the optimal management of pediatric chronic pain addresses its equally important biological, psychological, and social components. Nevertheless, despite significant advances in its management, pediatric chronic pain remains underdiagnosed, undertreated, and misunderstood. This discrepancy is largely due to the complexity and diversity of pediatric chronic pain and resulting clinical disconnect between its biomedical and psychosocial elements. This discussion will first present two theoretical models whose tenets and constructs form the basis and justification for a biopsychosocial approach to the management of pediatric chronic pain. The utility and perhaps the necessity of incorporating pediatric health-related quality as a multidimensional clinical measure will in turn be examined. Published biopsychosocial data on the types of pediatric patients who are typically referred to a pediatric pain medicine clinic will then be reviewed. Qualitative survey data on the pediatric chronic pain experience and its attendant personal narrative will also be reviewed in further support of its biopsychosocial nature. Finally, against the backdrop of the overall goal of multidisciplinary pediatric pain management, a brief synopsis of currently available evidence-based best practices, including biomedical and psychosocial modalities, will be provided. Potential areas for future research will lastly be highlighted.

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References

  • Aasland, A., Flato, B., & Vandvik, I. H. (1997). Psychosocial factors in children with idiopathic musculoskeletal pain: A prospective, longitudinal study. Acta Paediatrica, 86(7), 740–746.

    Article  PubMed  CAS  Google Scholar 

  • American Academy of Pediatrics. (2001). The new morbidity revisited: A renewed commitment to the psychosocial aspects of pediatric care. Committee on Psychosocial Aspects of Child and Family Health. Pediatrics, 108(5), 1227–1230.

    Article  Google Scholar 

  • American Academy of Pediatrics. (2003). Family-centered care and the pediatrician’s role. Pediatrics, 112(3 Pt 1), 691–697.

    Google Scholar 

  • American Academy of Pediatrics. (2005). Chronic abdominal pain in children. Pediatrics, 115(3), e370–e381.

    Article  Google Scholar 

  • Anderson, K. O., Green, C. R., & Payne, R. (2009). Racial and ethnic disparities in pain: Causes and consequences of unequal care. The Journal of Pain, 10(12), 1187–1204.

    Article  PubMed  Google Scholar 

  • Andrasik, F., & Schwartz, M. S. (2006). Behavioral assessment and treatment of pediatric headache. Behavior Modification, 30(1), 93–113.

    Article  PubMed  Google Scholar 

  • Bazzano, A. T., Mangione-Smith, R., Schonlau, M., Suttorp, M. J., & Brook, R. H. (2009). Off-label prescribing to children in the United States outpatient setting. Academic Pediatrics, 9(2), 81–88.

    Article  PubMed  Google Scholar 

  • Benjamin, D. K., Jr., Smith, P. B., Murphy, M. D., Roberts, R., Mathis, L., Avant, D., et al. (2006). Peer-reviewed publication of clinical trials completed for pediatric exclusivity. Journal of the American Medical Association, 296(10), 1266–1273.

    Article  PubMed  CAS  Google Scholar 

  • Benjamin, D. K., Jr., Smith, P. B., Sun, M. J., Murphy, M. D., Avant, D., Mathis, L., et al. (2009). Safety and transparency of pediatric drug trials. Archives of Pediatrics & Adolescent Medicine, 163(12), 1080–1086.

    Article  Google Scholar 

  • Bennett, S. M., Huntsman, E., & Lilley, C. M. (2000). Parent perceptions of the impact of chronic pain in children and adolescents. Children’s Health Care, 29(3), 147–159.

    Article  Google Scholar 

  • Berger, M. Y., Gieteling, M. J., & Benninga, M. A. (2007). Chronic abdominal pain in children. British Medical Journal, 334(7601), 997–1002.

    Article  PubMed  CAS  Google Scholar 

  • Bernard, S., Neville, K. A., Nguyen, A. T., & Flockhart, D. A. (2006). Interethnic differences in genetic polymorphisms of CYP2D6 in the U.S population: Clinical implications. The Oncologist, 11(2), 126–135.

    Article  PubMed  CAS  Google Scholar 

  • Beydoun, A., & Backonja, M. M. (2003). Mechanistic stratification of antineuralgic agents. Journal of Pain and Symptom Management, 25(5 Suppl), S18–S30.

    Article  PubMed  CAS  Google Scholar 

  • Bornhoft, G., Maxion-Bergemann, S., Wolf, U., Kienle, G. S., Michalsen, A., Vollmar, H. C., et al. (2006). Checklist for the qualitative evaluation of clinical studies with particular focus on external validity and model validity. BMC Medical Research Methodology, 6, 56.

    Article  PubMed  Google Scholar 

  • Bozkurt, P. (2005). Use of tramadol in children. Paediatric Anaesthesia, 15(12), 1041–1047.

    Article  PubMed  Google Scholar 

  • Brace, M. J., Scott Smith, M., McCauley, E., & Sherry, D. D. (2000). Family reinforcement of illness behavior: A comparison of adolescents with chronic fatigue syndrome, juvenile arthritis, and healthy controls. Journal of Developmental and Behavioral Pediatrics, 21(5), 332–339.

    Article  PubMed  CAS  Google Scholar 

  • Brattberg, G. (2004). Do pain problems in young school children persist into early adulthood? A 13-year follow-up. European Journal of Pain, 8(3), 187–199.

    Article  PubMed  Google Scholar 

  • Breitkreutz, J. (2008). European perspectives on pediatric formulations. Clinical Therapeutics, 30(11), 2146–2154.

    Article  PubMed  Google Scholar 

  • Brislin, R. P., & Rose, J. B. (2005). Pediatric acute pain management. Anesthesiology Clinics of North America, 23(4), 789–814.

    Article  PubMed  CAS  Google Scholar 

  • Bryson, H. M., & Wilde, M. I. (1996). Amitriptyline: A review of its pharmacological properties and therapeutic use in chronic pain states. Drugs & Aging, 8(6), 459–476.

    Article  CAS  Google Scholar 

  • Bursch, B., Walco, G. A., & Zeltzer, L. (1998). Clinical assessment and management of chronic pain and pain-­associated disability syndrome. Journal of Developmental and Behavioral Pediatrics, 19(1), 45–53.

    Article  PubMed  CAS  Google Scholar 

  • Buskila, D. (2009). Pediatric fibromyalgia. Rheumatic Diseases Clinics of North America, 35(2), 253–261.

    Article  PubMed  Google Scholar 

  • Caraco, Y. (2004). Genes and the response to drugs. The New England Journal of Medicine, 351(27), 2867–2869.

    Article  PubMed  CAS  Google Scholar 

  • Carr, D. B., Loeser, J. D., & Morris, D. B. (2005). Narrative, pain, and suffering. Seattle: IASP Press.

    Google Scholar 

  • Chambers, C. T. (2003). The role of family factors in pediatric pain. In P. J. McGrath & G. A. Finley (Eds.), Pediatric pain: Biological and social context (pp. 99–103). Seattle: IASP Press.

    Google Scholar 

  • Chambers, C. T., Craig, K. D., & Bennett, S. M. (2002). The impact of maternal behavior on children’s pain experiences: An experimental analysis. Journal of Pediatric Psychology, 27(3), 293–301.

    Article  PubMed  Google Scholar 

  • Chambliss, C. R., Heggen, J., Copelan, D. N., & Pettignano, R. (2002). The assessment and management of chronic pain in children. Paediatric Drugs, 4(11), 737–746.

    PubMed  Google Scholar 

  • Chen, D. T., Wynia, M. K., Moloney, R. M., & Alexander, G. C. (2009). U.S. physician knowledge of the FDA-approved indications and evidence base for commonly prescribed drugs: Results of a national survey. Pharmacoepidemiology and Drug Safety, 18(11), 1094–1100.

    Article  PubMed  Google Scholar 

  • Chung, A. M., & Eiland, L. S. (2008). Use of second-generation antiepileptic drugs in the pediatric population. Paediatric Drugs, 10(4), 217–254.

    Article  PubMed  Google Scholar 

  • Claar, R. L., Baber, K. F., Simons, L. E., Logan, D. E., & Walker, L. S. (2008). Pain coping profiles in adolescents with chronic pain. Pain, 140(2), 368–375.

    Article  PubMed  Google Scholar 

  • Clarke, S. A., & Eiser, C. (2004). The measurement of health-related quality of life (QOL) in paediatric clinical trials: A systematic review. Health and Quality of Life Outcomes, 2, 66.

    Article  PubMed  Google Scholar 

  • Clinch, J., & Eccleston, C. (2009). Chronic musculoskeletal pain in children: Assessment and management. Rheumatology (Oxford, England), 48(5), 466–474.

    Article  Google Scholar 

  • Collins, J. J., Dunkel, I. J., Gupta, S. K., Inturrisi, C. E., Lapin, J., Palmer, L. N., et al. (1999). Transdermal fentanyl in children with cancer pain: Feasibility, tolerability, and pharmacokinetic correlates. The Journal of Pediatrics, 134(3), 319–323.

    Article  PubMed  CAS  Google Scholar 

  • Conger, K. J., Rueter, M. A., & Conger, R. D. (2000). The role of economic pressure in the lives of parents and their adolescents: The family stress model. In L. J. Crockeet & R. J. Silbereisen (Eds.), Negotiating adolescence in times of social change (pp. 201–233). Cambridge: Cambridge University Press.

    Google Scholar 

  • Conger, R. D., & Donnellan, M. B. (2007). An Interactionist perspective on the socioeconomic context of human development. Annual Review of Psychology, 58, 175–199.

    Article  PubMed  Google Scholar 

  • Connelly, M., & Schanberg, L. (2006). Latest developments in the assessment and management of chronic musculoskeletal pain syndromes in children. Current Opinion in Rheumatology, 18(5), 496–502.

    Article  PubMed  Google Scholar 

  • Cremeens, J., Eiser, C., & Blades, M. (2006). Factors influencing agreement between child self-report and parent proxy-reports on the Pediatric Quality of Life Inventory 4.0 (PedsQL) generic core scales. Health and Quality of Life Outcomes, 4, 58.

    Article  PubMed  Google Scholar 

  • Cruz, M. J., Valencia, I., Legido, A., Kothare, S. V., Khurana, D. S., Yum, S., et al. (2009). Efficacy and tolerability of topiramate in pediatric migraine. Pediatric Neurology, 41(3), 167–170.

    Article  PubMed  Google Scholar 

  • Davies, E. H., Ollivier, C. M., & Saint Raymond, A. (2010). Paediatric investigation plans for pain: Painfully slow! European Journal of Clinical Pharmacology, 66(11), 1091–1097.

    Article  PubMed  Google Scholar 

  • De Civita, M., Regier, D., Alamgir, A. H., Anis, A. H., Fitzgerald, M. J., & Marra, C. A. (2005). Evaluating health-related quality-of-life studies in paediatric populations: Some conceptual, methodological and developmental considerations and recent applications. PharmacoEconomics, 23(7), 659–685.

    Article  PubMed  Google Scholar 

  • Degotardi, P. J., Klass, E. S., Rosenberg, B. S., Fox, D. G., Gallelli, K. A., & Gottlieb, B. S. (2006). Development and evaluation of a cognitive-behavioral intervention for juvenile fibromyalgia. Journal of Pediatric Psychology, 31(7), 714–723.

    Article  PubMed  Google Scholar 

  • Drotar, D. (2004a). Measuring child health: Scientific questions, challenges, and recommendations. Ambulatory Pediatrics, 4(4 Suppl), 353–357.

    Article  PubMed  Google Scholar 

  • Drotar, D. (2004b). Validating measures of pediatric health status, functional status, and health-related quality of life: Key methodological challenges and strategies. Ambulatory Pediatrics, 4(4 Suppl), 358–364.

    Article  PubMed  Google Scholar 

  • Duarte, M. A., Penna, F. J., Andrade, E. M., Cancela, C. S., Neto, J. C., & Barbosa, T. F. (2006). Treatment of nonorganic recurrent abdominal pain: Cognitive-behavioral family intervention. Journal of Pediatric Gastroenterology and Nutrition, 43(1), 59–64.

    Article  PubMed  Google Scholar 

  • Eccleston, C., & Clinch, J. (2007). Adolescent chronic pain and disability: A review of the current evidence in assessment and treatment. Paediatrics & Child Health, 12(2), 117–120.

    Google Scholar 

  • Eccleston, C., Crombez, G., Scotford, A., Clinch, J., & Connell, H. (2004). Adolescent chronic pain: Patterns and predictors of emotional distress in adolescents with chronic pain and their parents. Pain, 108(3), 221–229.

    Article  PubMed  Google Scholar 

  • Eccleston, C., Malleson, P. N., Clinch, J., Connell, H., & Sourbut, C. (2003). Chronic pain in adolescents: Evaluation of a programme of interdisciplinary cognitive behaviour therapy. Archives of Disease in Childhood, 88(10), 881–885.

    Article  PubMed  CAS  Google Scholar 

  • Eccleston, C., Palermo, T. M., Williams, A. C., Lewandowski, A., & Morley, S. (2009). Psychological therapies for the management of chronic and recurrent pain in children and adolescents. Cochrane Database Systemic Reviews, (2), CD003968.

    Google Scholar 

  • Edwards, C. L., Fillingim, R. B., & Keefe, F. (2001). Race, ethnicity and pain. Pain, 94(2), 133–137.

    Article  PubMed  CAS  Google Scholar 

  • Edwards, R. R., Moric, M., Husfeldt, B., Buvanendran, A., & Ivankovich, O. (2005). Ethnic similarities and differences in the chronic pain experience: A comparison of African American, Hispanic, and white patients. Pain Medicine, 6(1), 88–98.

    Article  PubMed  Google Scholar 

  • Eiser, C. (2004). Use of quality of life measures in clinical trials. Ambulatory Pediatrics, 4(4), 395–399.

    Article  PubMed  Google Scholar 

  • Eiser, C., Mohay, H., & Morse, R. (2000). The measurement of quality of life in young children. Child: Care, Health and Development, 26(5), 401–414.

    Article  CAS  Google Scholar 

  • Eiser, C., & Morse, R. (2001a). Can parents rate their child’s health-related quality of life? Results of a systematic review. Quality of Life Research, 10(4), 347–357.

    Article  PubMed  CAS  Google Scholar 

  • Eiser, C., & Morse, R. (2001b). The measurement of quality of life in children: Past and future perspectives. Journal of Developmental and Behavioral Pediatrics, 22(4), 248–256.

    Article  PubMed  CAS  Google Scholar 

  • Eiser, C., & Morse, R. (2001c). Quality-of-life measures in chronic diseases of childhood. Health Technology Assessment, 5(4), 1–157.

    PubMed  CAS  Google Scholar 

  • Estellat, C., Torgerson, D. J., & Ravaud, P. (2009). How to perform a critical analysis of a randomised controlled trial. Best Practice & Research. Clinical Rheumatology, 23(2), 291–303.

    Article  Google Scholar 

  • Finkel, J. C., Finley, A., Greco, C., Weisman, S. J., & Zeltzer, L. (2005). Transdermal fentanyl in the management of children with chronic severe pain: Results from an international study. Cancer, 104(12), 2847–2857.

    Article  PubMed  CAS  Google Scholar 

  • Finkel, J. C., Rose, J. B., Schmitz, M. L., Birmingham, P. K., Ulma, G. A., Gunter, J. B., et al. (2002). An evaluation of the efficacy and tolerability of oral tramadol hydrochloride tablets for the treatment of postsurgical pain in children. Anesthesia and Analgesia, 94(6), 1469–1473.

    PubMed  CAS  Google Scholar 

  • Finley, G. A. (Ed.). (2006). Bringing pain relief to children: Treatment approaches. New York: Humana Press.

    Google Scholar 

  • Flores, G. (2010). Technical report – Racial and ethnic disparities in the health and health care of children. Pediatrics, 125(4), e979–e1020.

    Article  PubMed  Google Scholar 

  • Forgeron, P. A., King, S., Stinson, J. N., McGrath, P. J., MacDonald, A. J., & Chambers, C. T. (2010). Social functioning and peer relationships in children and adolescents with chronic pain: A systematic review. Pain Research & Management, 15(1), 27–41.

    Google Scholar 

  • Forrest, C. B., Shipman, S. A., Dougherty, D., & Miller, M. R. (2003). Outcomes research in pediatric settings: Recent trends and future directions. Pediatrics, 111(1), 171–178.

    Article  PubMed  Google Scholar 

  • Fortier, M. A., Anderson, C. T., & Kain, Z. N. (2009). Ethnicity matters in the assessment and treatment of children’s pain. Pediatrics, 124(1), 378–380.

    Article  PubMed  Google Scholar 

  • Frank, A. W. (1995). The wounded storyteller: Body, illness, and ethics. Chicago: University of Chicago Press.

    Article  PubMed  Google Scholar 

  • Franzoni, E., Gentile, V., Pellicciari, A., Garone, C., Iero, L., Gualandi, S., et al. (2009). Prospective study on long-term treatment with oxcarbazepine in pediatric epilepsy. Journal of Neurology, 256(9), 1527–1532.

    Article  PubMed  CAS  Google Scholar 

  • Friedrichsdorf, S. J., & Kang, T. I. (2007). The management of pain in children with life-limiting illnesses. Pediatric Clinics of North America, 54(5), 645–672.

    Article  PubMed  Google Scholar 

  • Gaffney, A., McGrath, P. A., & Dick, B. (2003). Measuring pain in children: Developemental and instrument issues. In N. L. Schechter, C. B. Berde, & M. Yaster (Eds.), Pain in infants, children, and adolescents (2nd ed., pp. 128–141). Philadelphia: Lippincott Williams & Wilkins.

    Google Scholar 

  • Gardiner, S. J., & Begg, E. J. (2006). Pharmacogenetics, drug-metabolizing enzymes, and clinical practice. Pharmacological Reviews, 58(3), 521–590.

    Article  PubMed  CAS  Google Scholar 

  • Gauntlett-Gilbert, J., & Eccleston, C. (2007). Disability in adolescents with chronic pain: Patterns and predictors across different domains of functioning. Pain, 131(1–2), 132–141.

    Article  PubMed  Google Scholar 

  • Gold, J. I., Yetwin, A. K., Mahrer, N. E., Carson, M. C., Griffin, A. T., Palmer, S. N., et al. (2009). Pediatric chronic pain and health-related quality of life. Journal of Pediatric Nursing, 24(2), 141–150.

    Article  PubMed  Google Scholar 

  • Graumlich, S. E., Powers, S. W., Byars, K. C., Schwarber, L. A., Mitchell, M. J., & Kalinyak, K. A. (2001). Multidimensional assessment of pain in pediatric sickle cell disease. Journal of Pediatric Psychology, 26(4), 203–214.

    Article  PubMed  CAS  Google Scholar 

  • Green, C. (2011). Disparities in pain management and palliative care. In R. J. Moore (Ed.), Handbook of pain and palliative care: Biobehavioral approaches for the life course. New York: Springer.

    Google Scholar 

  • Green, C. R., Baker, T. A., Smith, E. M., & Sato, Y. (2003). The effect of race in older adults presenting for chronic pain management: A comparative study of black and white Americans. The Journal of Pain, 4(2), 82–90.

    Article  PubMed  Google Scholar 

  • Grond, S., & Sablotzki, A. (2004). Clinical pharmacology of tramadol. Clinical Pharmacokinetics, 43(13), 879–923.

    Article  PubMed  CAS  Google Scholar 

  • Guyatt, G. H., Feeny, D. H., & Patrick, D. L. (1993). Measuring health-related quality of life. Annals of Internal Medicine, 118(8), 622–629.

    Article  PubMed  CAS  Google Scholar 

  • Haig, G. M., Bockbrader, H. N., Wesche, D. L., Boellner, S. W., Ouellet, D., Brown, R. R., et al. (2001). Single-dose gabapentin pharmacokinetics and safety in healthy infants and children. The Journal of Clinical Pharmacology, 41(5), 507–514.

    Article  CAS  Google Scholar 

  • Hatzmann, J., Heymans, H. S., Ferrer-i-Carbonell, A., van Praag, B. M., & Grootenhuis, M. A. (2008). Hidden consequences of success in pediatrics: Parental health-related quality of life – results from the Care Project. Pediatrics, 122(5), e1030–e1038.

    Article  PubMed  Google Scholar 

  • Hauser, W., Bernardy, K., Uceyler, N., & Sommer, C. (2009). Treatment of fibromyalgia syndrome with gabapentin and pregabalin – A meta-analysis of randomized controlled trials. Pain, 145(1–2), 69–81.

    Article  PubMed  CAS  Google Scholar 

  • Hershey, A. D., Kabbouche, M. A., & Powers, S. W. (2006). Chronic daily headaches in children. Current Pain and Headache Reports, 10(5), 370–376.

    Article  PubMed  Google Scholar 

  • Hershey, A. D., Winner, P., Kabbouche, M. A., & Powers, S. W. (2007). Headaches. Current Opinion in Pediatrics, 19(6), 663–669.

    Article  PubMed  Google Scholar 

  • Holmbeck, G. N., Thill, A. W., Bachanas, P., Garber, J., Miller, K. B., Abad, M., Holmbeck, G. N., Thill, A. W., Bachanas, P., Garber, J., Miller, K. B., Abad, M., et al. (2008). Evidence-based assessment in pediatric psychology: Measures of psychosocial adjustment and psychopathology. Journal of Pediatric Psychology, 33(9), 958–980. discussion 952–981.

    Article  PubMed  Google Scholar 

  • Holmes, G. L. (1997). Gabapentin for treatment of epilepsy in children. Seminars in Pediatric Neurology, 4(3), 244–250.

    Article  PubMed  CAS  Google Scholar 

  • Holroyd, K. A., & Drew, J. B. (2006). Behavioral approaches to the treatment of migraine. Seminars in Neurology, 26(2), 199–207.

    Article  PubMed  Google Scholar 

  • Huertas-Ceballos, A., Logan, S., Bennett, C., & Macarthur, C. (2008). Psychosocial interventions for recurrent abdominal pain (RAP) and irritable bowel syndrome (IBS) in childhood. Cochrane Database Systemic Reviews, (1), CD003014.

    Google Scholar 

  • Hunfeld, J. A., Perquin, C. W., Bertina, W., Hazebroek-Kampschreur, A. J. M., van Suijlekom-Smit, L. W. A., Koes, B. W., et al. (2002a). Stability of pain parameters and pain-related quality of life in adolescents with persistent pain: A three-year follow-up. The Clinical Journal of Pain, 18(2), 99–106.

    Article  PubMed  Google Scholar 

  • Hunfeld, J. A., Perquin, C. W., Duivenvoorden, H. J., Hazebroek-Kampschreur, A. A., Passchier, J., van Suijlekom-Smit, L. W., et al. (2001). Chronic pain and its impact on quality of life in adolescents and their families. Journal of Pediatric Psychology, 26(3), 145–153.

    Article  PubMed  CAS  Google Scholar 

  • Hunfeld, J. A., Perquin, C. W., Hazebroek-Kampschreur, A. J. M., Passchier, J., van Suijlekom-Smit, L. W. A., & van der Wouden, J. C. (2002b). Physically unexplained chronic pain and its impact on children and their families: The mother’s perception. Psychology and Psychotherapy, 75(Pt 3), 251–260.

    Article  PubMed  Google Scholar 

  • Hwang, H., & Kim, K. J. (2008). New antiepileptic drugs in pediatric epilepsy. Brain & Development, 30(9), 549–555.

    Article  Google Scholar 

  • Jindal, V., Ge, A., & Mansky, P. J. (2008). Safety and efficacy of acupuncture in children: A review of the evidence. Journal of Pediatric Hematology/Oncology, 30(6), 431–442.

    Article  PubMed  Google Scholar 

  • Jordan, A. (2005). The impact of pediatric chronic pain on the family. Pediatric pain letter: Commentaries on pain in infants, children, and adolescents. Retrieved September 6, 2010, from http://pediatric-pain.ca/ppl/issues/v7n1_2005/v7n1_jordan.pdf.

  • Juni, P., Altman, D. G., & Egger, M. (2001). Systematic reviews in health care: Assessing the quality of controlled clinical trials. British Medical Journal, 323(7303), 42–46.

    Article  PubMed  CAS  Google Scholar 

  • Kashikar-Zuck, S., Goldschneider, K. R., Powers, S. W., Vaught, M. H., & Hershey, A. D. (2001). Depression and functional disability in chronic pediatric pain. The Clinical Journal of Pain, 17(4), 341–349.

    Article  PubMed  CAS  Google Scholar 

  • Kashikar-Zuck, S., Lynch, A. M., Graham, T. B., Swain, N. F., Mullen, S. M., & Noll, R. B. (2007). Social functioning and peer relationships of adolescents with juvenile fibromyalgia syndrome. Arthritis and Rheumatism, 57(3), 474–480.

    Article  PubMed  Google Scholar 

  • Kashikar-Zuck, S., Swain, N. F., Jones, B. A., & Graham, T. B. (2005). Efficacy of cognitive-behavioral intervention for juvenile primary fibromyalgia syndrome. The Journal of Rheumatology, 32(8), 1594–1602.

    PubMed  Google Scholar 

  • Kazdin, A. E. (2005). Evidence-based assessment for children and adolescents: Issues in measurement development and clinical application. Journal of Clinical Child and Adolescent Psychology, 34(3), 548–558.

    Article  PubMed  Google Scholar 

  • Kemper, K. J., Sarah, R., Silver-Highfield, E., Xiarhos, E., Barnes, L., & Berde, C. (2000). On pins and needles? Pediatric pain patients’ experience with acupuncture. Pediatrics, 105(4 Pt 2), 941–947.

    PubMed  CAS  Google Scholar 

  • Keogh, E. (2011). Sex differences in pain across the life course. In R. J. Moore (Ed.), Handbook of pain and palliative care: Biobehavioral approaches for the life course. New York: Springer.

    Google Scholar 

  • Knight, T. S., Burwinkle, T. M., & Varni, J. W. (2003). Heath-related quality of life. In E. J. Sobo & P. S. Kurtin (Eds.), Child health services research: Application, innovations, and insights (pp. 209–241). San Francisco: Jossey-Bass.

    Google Scholar 

  • Knotkova, H., & Pappagallo, M. (2007). Adjuvant analgesics. The Medical Clinics of North America, 91(1), 113–124.

    Article  PubMed  CAS  Google Scholar 

  • Kong, V. K., & Irwin, M. G. (2009). Adjuvant analgesics in neuropathic pain. European Journal of Anaesthesiology, 26(2), 96–100.

    Article  PubMed  CAS  Google Scholar 

  • Kothare, S. V., Mostofi, N., Khurana, D. S., Mohsem, B., Melvin, J. J., Hardison, H. H., et al. (2006). Oxcarbazepine therapy in very young children: A single-center clinical experience. Pediatric Neurology, 35(3), 173–176.

    Article  PubMed  Google Scholar 

  • Kozlowska, K., Rose, D., Khan, R., Kram, S., Lane, L., & Collins, J. (2008). A conceptual model and practice framework for managing chronic pain in children and adolescents. Harvard Review of Psychiatry, 16(2), 136–150.

    Article  PubMed  Google Scholar 

  • Kraemer, F. W., & Rose, J. B. (2009). Pharmacologic management of acute pediatric pain. Anesthesiology Clinics, 27(2), 241–268.

    Article  PubMed  CAS  Google Scholar 

  • Kroenke, K., Krebs, E. E., & Bair, M. J. (2009). Pharmacotherapy of chronic pain: A synthesis of recommendations from systematic reviews. General Hospital Psychiatry, 31(3), 206–219.

    Article  PubMed  Google Scholar 

  • Kundu, A., & Berman, B. (2007). Acupuncture for pediatric pain and symptom management. Pediatric Clinics of North America, 54(6), 885–889.

    Article  PubMed  Google Scholar 

  • Lago, P., Garetti, E., Merazzi, D., Pieragostini, L., Ancora, G., Pirelli, A., et al. (2009). Guidelines for procedural pain in the newborn. Acta Paediatrica, 98(6), 932–939.

    Article  PubMed  CAS  Google Scholar 

  • Lakshmi, C. V., Singhi, P., Malhi, P., & Ray, M. (2007). Topiramate in the prophylaxis of pediatric migraine: A double-blind placebo-controlled trial. Journal of Child Neurology, 22(7), 829–835.

    Article  PubMed  CAS  Google Scholar 

  • Lalwani, K., Shoham, A., Koh, J. L., & McGraw, T. (2005). Use of oxcarbazepine to treat a pediatric patient with resistant complex regional pain syndrome. The Journal of Pain, 6(10), 704–706.

    Article  PubMed  CAS  Google Scholar 

  • Landgraf, J. M., & Abetz, L. (1996). Measuring health outcomes in pediatric populations: Issues in psychometrics and application. In B. Spilker (Ed.), Quality of life and pharmacoeconomics in clinical trials (2nd ed., pp. 793–802). Philadelphia: Lippincott-Raven Publishers.

    Google Scholar 

  • Lee, B. H., Scharff, L., Sethna, N. F., McCarthy, C. F., Scott-Sutherland, J., Shea, A. M., et al. (2002). Physical therapy and cognitive-behavioral treatment for complex regional pain syndromes. The Journal of Pediatrics, 141(1), 135–140.

    Article  PubMed  Google Scholar 

  • Levy, R. L., Langer, S. L., Walker, L. S., Romano, J. M., Christie, D. L., Youssef, N., et al. (2010). Cognitive-behavioral therapy for children with functional abdominal pain and their parents decreases pain and other symptoms. The American Journal of Gastroenterology, 105(4), 946–956.

    Article  PubMed  Google Scholar 

  • Lewis, D. (2009). Pediatric migraine. Neurologic Clinics, 27(2), 481–501.

    Article  PubMed  Google Scholar 

  • Lewis, D., Winner, P., Saper, J., Ness, S., Polverejan, E., Wang, S., et al. (2009). Randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of topiramate for migraine prevention in pediatric subjects 12 to 17 years of age. Pediatrics, 123(3), 924–934.

    Article  PubMed  Google Scholar 

  • Lexi-Comp. (2010). Amitriptyline. Merck maunal online medical libraries Retrieved September 6, 2010, from http://www.merck.com/mmpe/print/lexicomp/amitriptyline.html.

  • Li, J. S., Eisenstein, E. L., Grabowski, H. G., Reid, E. D., Mangum, B., Schulman, K. A., et al. (2007). Economic return of clinical trials performed under the pediatric exclusivity program. Journal of the American Medical Association, 297(5), 480–488.

    Article  PubMed  CAS  Google Scholar 

  • Libonate, J., Evans, S., & Tsao, J. C. (2008). Efficacy of acupuncture for health conditions in children: A review. Scientific World Journal, 8, 670–682.

    Article  PubMed  Google Scholar 

  • Lin, Y. C., Lee, A. C., Kemper, K. J., & Berde, C. B. (2005). Use of complementary and alternative medicine in pediatric pain management service: A survey. Pain Medicine, 6(6), 452–458.

    Article  PubMed  Google Scholar 

  • Logan, D. E., Claar, R. L., & Scharff, L. (2008a). Social desirability response bias and self-report of psychological distress in pediatric chronic pain patients. Pain, 136(3), 366–372.

    Article  PubMed  Google Scholar 

  • Logan, D. E., & Scharff, L. (2005). Relationships between family and parent characteristics and functional abilities in children with recurrent pain syndromes: An investigation of moderating effects on the pathway from pain to disability. Journal of Pediatric Psychology, 30(8), 698–707.

    Article  PubMed  Google Scholar 

  • Logan, D. E., Simons, L. E., & Kaczynski, K. J. (2009). School functioning in adolescents with chronic pain: The role of depressive symptoms in school impairment. Journal of Pediatric Psychology, 34(8), 882–892.

    Article  PubMed  Google Scholar 

  • Logan, D. E., Simons, L. E., Stein, M. J., & Chastain, L. (2008b). School impairment in adolescents with chronic pain. The Journal of Pain, 9(5), 407–416.

    Article  PubMed  Google Scholar 

  • Long, A. C., & Palermo, T. M. (2009). Brief report: Web-based management of adolescent chronic pain: Development and usability testing of an online family cognitive behavioral therapy program. Journal of Pediatric Psychology, 34(5), 511–516.

    Article  PubMed  Google Scholar 

  • Lynch, A. M., Kashikar-Zuck, S., Goldschneider, K. R., & Jones, B. A. (2006). Psychosocial risks for disability in children with chronic back pain. The Journal of Pain, 7(4), 244–251.

    Article  PubMed  Google Scholar 

  • Malaty, H. M., Abudayyeh, S., O’Malley, K. J., Wilsey, M. J., Fraley, K., Gilger, M. A., et al. (2005). Development of a multidimensional measure for recurrent abdominal pain in children: Population-based studies in three settings. Pediatrics, 115(2), e210–e215.

    Article  PubMed  Google Scholar 

  • Malleson, P., & Clinch, J. (2003). Pain syndromes in children. Current Opinion in Rheumatology, 15(5), 572–580.

    Article  PubMed  Google Scholar 

  • Manolis, E., & Pons, G. (2009). Proposals for model-based paediatric medicinal development within the current European Union regulatory framework. British Journal of Clinical Pharmacology, 68(4), 493–501.

    Article  PubMed  Google Scholar 

  • Mao, J., Gold, M. S., & Backonja, M. M. (2011). Combination drug therapy for chronic pain: A call for more clinical studies. The Journal of Pain, 12(2), 157–166.

    Article  PubMed  CAS  Google Scholar 

  • Matza, L. S., Swensen, A. R., Flood, E. M., Secnik, K., & Leidy, N. K. (2004). Assessment of health-related quality of life in children: A review of conceptual, methodological, and regulatory issues. Value in Health, 7(1), 79–92.

    Article  PubMed  Google Scholar 

  • McClain, B. C., & Suresh, S. (Eds.). (2010). Handbook of pediatric chronic pain: Current science and integrative practice. New York: Springer.

    Google Scholar 

  • McGrath, P. A., & Hillier, L. M. (2003). Modifying the psychological factors that intensify chidren’s pain and prolong disability. In N. L. Schechter, C. B. Berde, & M. Yaster (Eds.), Pain in infants, children, and adolescents (2nd ed., pp. 85–104). Philadelphia: Lippincott Williams & Wilkins.

    Google Scholar 

  • McGrath, P. A., & Ruskin, D. A. (2007). Caring for children with chronic pain: Ethical considerations. Paediatric Anaesthesia, 17(6), 505–508.

    Article  PubMed  Google Scholar 

  • McGrath, P. J., Walco, G. A., Turk, D. C., Dworkin, R. H., Brown, M. T., Davidson, K., et al. (2008). Core outcome domains and measures for pediatric acute and chronic/recurrent pain clinical trials: PedIMMPACT recommendations. The Journal of Pain, 9(9), 771–783.

    Article  PubMed  Google Scholar 

  • Meldrum, M. L., Tsao, J. C., & Zeltzer, L. K. (2008). “Just be in pain and just move on”: Functioning limitations and strategies in the lives of children with chronic pain. Journal of Pain Management, 1(2), 131–141.

    PubMed  Google Scholar 

  • Meldrum, M. L., Tsao, J. C., & Zeltzer, L. K. (2009). “I can’t be what I want to be”: Children’s narratives of chronic pain experiences and treatment outcomes. Pain Medicine, 10(6), 1018–1034.

    Article  PubMed  Google Scholar 

  • Merlijn, V. P. B. M., Hunfeld, J. A. M., van der Wouden, J. C., Hazebroek-Kampschreur, A. A. J. M., Passchier, J., & Koes, B. W. (2006). Factors related to the quality of life in adolescents with chronic pain. The Clinical Journal of Pain, 22(3), 306–315.

    Article  PubMed  Google Scholar 

  • Milne, C. P., & Bruss, J. B. (2008). The economics of pediatric formulation development for off-patent drugs. Clinical Therapeutics, 30(11), 2133–2145.

    Article  PubMed  Google Scholar 

  • Miro, J., Huguet, A., & Nieto, R. (2007). Predictive factors of chronic pediatric pain and disability: A Delphi poll. The Journal of Pain, 8(10), 774–792.

    Article  PubMed  Google Scholar 

  • Morris, D. B. (2011). Narrative and pain: Towards an integrative model. In R. J. Moore (Ed.), Handbook of pain and palliative care: Biobehavioral approaches for the life course. New York: Springer.

    Google Scholar 

  • Mulvaney, S., Lambert, E. W., Garber, J., & Walker, L. S. (2006). Trajectories of symptoms and impairment for pediatric patients with functional abdominal pain: A 5-year longitudinal study. Journal of the American Academy of Child and Adolescent Psychiatry, 45(6), 737–744.

    Article  PubMed  Google Scholar 

  • Nguyen, M., Ugarte, C., Fuller, I., Haas, G., & Portenoy, R. K. (2005). Access to care for chronic pain: Racial and ethnic differences. The Journal of Pain, 6(5), 301–314.

    Article  PubMed  Google Scholar 

  • Palermo, T. M. (2000). Impact of recurrent and chronic pain on child and family daily functioning: A critical review of the literature. Journal of Developmental and Behavioral Pediatrics, 21(1), 58–69.

    Article  PubMed  CAS  Google Scholar 

  • Palermo, T. M. (2009). Assessment of chronic pain in children: Current status and emerging topics. Pain Research & Management, 14(1), 21–26.

    Google Scholar 

  • Palermo, T. M., & Chambers, C. T. (2005). Parent and family factors in pediatric chronic pain and disability: An integrative approach. Pain, 119(1–3), 1–4.

    Article  PubMed  Google Scholar 

  • Palermo, T. M., Long, A. C., Lewandowski, A. S., Drotar, D., Quittner, A. L., & Walker, L. S. (2008). Evidence-based assessment of health-related quality of life and functional impairment in pediatric psychology. Journal of Pediatric Psychology, 33(9), 983–996.

    Article  PubMed  Google Scholar 

  • Palermo, T. M., Wilson, A. C., Peters, M., Lewandowski, A., & Somhegyi, H. (2009). Randomized controlled trial of an Internet-delivered family cognitive-behavioral therapy intervention for children and adolescents with chronic pain. Pain, 146(1–2), 205–213.

    Article  PubMed  Google Scholar 

  • Panepinto, J. A., O’Mahar, K. M., DeBaun, M. R., Loberiza, F. R., & Scott, J. P. (2005). Health-related quality of life in children with sickle cell disease: Child and parent perception. British Journal of Haematology, 130(3), 437–444.

    Article  PubMed  Google Scholar 

  • Parsons, S. K., & Mayer, D. K. (2004). Health-related quality of life assessment in hematologic disease. Hematology/Oncology Clinics of North America, 18(6), 1235–1248.

    Article  PubMed  Google Scholar 

  • Perquin, C. W., Hunfeld, J. A., Hazebroek-Kampschreur, A. A., van Suijlekom-Smit, L. A., Passchier, J., Koes, B. W., et al. (2003). The natural course of chronic benign pain in childhood and adolescence: A two-year population-based follow-up study. European Journal of Pain, 7(6), 551–559.

    Article  PubMed  Google Scholar 

  • Peterson, C. C., & Palermo, T. M. (2004). Parental reinforcement of recurrent pain: The moderating impact of child depression and anxiety on functional disability. Journal of Pediatric Psychology, 29(5), 331–341.

    Article  PubMed  Google Scholar 

  • Pina-Garza, J. E., Espinoza, R., Nordli, D., Bennett, D. A., Spirito, S., Stites, T. E., et al. (2005). Oxcarbazepine adjunctive therapy in infants and young children with partial seizures. Neurology, 65(9), 1370–1375.

    Article  PubMed  CAS  Google Scholar 

  • Portenoy, R. K., Ugarte, C., Fuller, I., & Haas, G. (2004). Population-based survey of pain in the United States: Differences among white, African American, and Hispanic subjects. The Journal of Pain, 5(6), 317–328.

    Article  PubMed  Google Scholar 

  • Powers, S. W., & Andrasik, F. (2005). Biobehavioral treatment, disability, and psychological effects of pediatric headache. Pediatric Annals, 34(6), 461–465.

    PubMed  Google Scholar 

  • Radley, D. C., Finkelstein, S. N., & Stafford, R. S. (2006). Off-label prescribing among office-based physicians. Archives of Internal Medicine, 166(9), 1021–1026.

    Article  PubMed  Google Scholar 

  • Ransom, S., Pearman, T. P., Philip, E., & Anwar, D. (2011). Adult cancer-related pain. In R. J. Moore (Ed.), Handbook of pain and palliative care: Biobehavioral approaches for the life course. New York: Springer.

    Google Scholar 

  • Rice, L. J. (1996). Pain management in children. Canadian Journal of Anaesthesia, 43(5 Pt 2), R155–R162.

    Article  PubMed  CAS  Google Scholar 

  • Riley, J. L., III, Wade, J. B., Myers, C. D., Sheffield, D., Papas, R. K., & Price, D. D. (2002). Racial/ethnic differences in the experience of chronic pain. Pain, 100(3), 291–298.

    Article  PubMed  Google Scholar 

  • Roberts, R., Rodriguez, W., Murphy, D., & Crescenzi, T. (2003). Pediatric drug labeling: Improving the safety and efficacy of pediatric therapies. Journal of the American Medical Association, 290(7), 905–911.

    Article  PubMed  Google Scholar 

  • Robins, P. M., Smith, S. M., Glutting, J. J., & Bishop, C. T. (2005). A randomized controlled trial of a cognitive-behavioral family intervention for pediatric recurrent abdominal pain. Journal of Pediatric Psychology, 30(5), 397–408.

    Article  PubMed  Google Scholar 

  • Rose, J. B., Finkel, J. C., Arquedas-Mohs, A., Himelstein, B. P., Schreiner, M., & Medve, R. A. (2003). Oral tramadol for the treatment of pain of 7–30 days’ duration in children. Anesthesia and Analgesia, 96(1), 78–81.

    PubMed  CAS  Google Scholar 

  • Rosen, N. L. (2008). Psychological issues in the evaluation and treatment of tension-type headache. Current Pain and Headache Reports, 12(6), 425–432.

    Article  PubMed  Google Scholar 

  • Roth-Isigkeit, A., Thyen, U., Stoven, H., Schwarzenberger, J., & Schmucker, P. (2005). Pain among children and adolescents: Restrictions in daily living and triggering factors. Pediatrics, 115(2), e152–e162.

    Article  PubMed  Google Scholar 

  • Rothwell, P. M. (2005). External validity of randomised controlled trials: “to whom do the results of this trial apply?”. The Lancet, 365(9453), 82–93.

    Article  Google Scholar 

  • Rudolph, K. D., & Lambet, S. F. (2007). Child and adoescent depression. In E. J. Mash & R. A. Barkley (Eds.), Assessment of childhood disorders (4th ed., pp. 213–252). New York: The Guilford Press.

    Google Scholar 

  • Sansone, R. A., & Sansone, L. A. (2009). Tramadol: Seizures, serotonin syndrome, and coadministered antidepressants. Psychiatry (Edgmont), 6(4), 17–21.

    Google Scholar 

  • Sawyer, M. G., Carbone, J. A., Whitham, J. N., Roberton, D. M., Taplin, J. E., Varni, J. W., et al. (2005). The relationship between health-related quality of life, pain, and coping strategies in juvenile arthritis – A one year prospective study. Quality of Life Research, 14(6), 1585–1598.

    Article  PubMed  Google Scholar 

  • Sawyer, M. G., Whitham, J. N., Roberton, D. M., Taplin, J. E., Varni, J. W., & Baghurst, P. A. (2004). The relationship between health-related quality of life, pain and coping strategies in juvenile idiopathic arthritis. Rheumatology, 43(3), 325–330.

    Article  PubMed  CAS  Google Scholar 

  • Schechter, N. L., Berde, C. B., & Yaster, M. (2003). Pain in infants, children, and adolescents: An overview. In N. L. Schechter, C. B. Berde, & M. Yaster (Eds.), Pain in infants, children, and adolescents (2nd ed., pp. 3–18). Philadelphia: Lippincott Williams & Wilkins.

    Google Scholar 

  • Schor, E. L. (2003). Family pediatrics: Report of the task force on the family. Pediatrics, 111(6 Pt 2), 1541–1571.

    PubMed  Google Scholar 

  • Schwartz, L. A., Radcliffe, J., & Barakat, L. P. (2007). The development of a culturally sensitive pediatric pain management intervention for African American adolescents with sickle cell disease. Children’s Health Care, 36(3), 267–283.

    Article  PubMed  Google Scholar 

  • Simons, L. E., Claar, R. L., & Logan, D. L. (2008). Chronic pain in adolescence: Parental responses, adolescent coping, and their impact on adolescent’s pain behaviors. Journal of Pediatric Psychology, 33(8), 894–904.

    Article  PubMed  Google Scholar 

  • Simons, L. E., Logan, D. E., Chastain, L., & Cerullo, M. (2010a). Engagement in multidisciplinary interventions for pediatric chronic pain: Parental expectations, barriers, and child outcomes. The Clinical Journal of Pain, 26(4), 291–299.

    Article  PubMed  Google Scholar 

  • Simons, L. E., Logan, D. E., Chastain, L., & Stein, M. (2010b). The relation of social functioning to school impairment among adolescents with chronic pain. The Clinical Journal of Pain, 26(1), 16–22.

    Article  PubMed  Google Scholar 

  • Southam-Gerow, M. A., & Chorpita, B. F. (2007). Anxiety in children and adolescents. In E. J. Mash & R. A. Barkley (Eds.), Assessment of childhood disorders (4th ed., pp. 347–397). New York: The Guilford Press.

    Google Scholar 

  • Stevens, B. (1994). Pain assessment in children: Birth through adolescence. Child and Adolescent Clinics of North America, 6, 725–743.

    Google Scholar 

  • Tashakori, A., & Afshari, R. (2010). Tramadol overdose as a cause of serotonin syndrome: A case series. Clinical Toxicology (Philadelphia), 48(4), 337–341.

    Article  CAS  Google Scholar 

  • Theunissen, N. C., Vogels, T. G., Koopman, H. M., Verrips, G. H., Zwinderman, K. A., Verloove-Vanhorick, S. P., et al. (1998). The proxy problem: Child report versus parent report in health-related quality of life research. Quality of Life Research, 7(5), 387–397.

    Article  PubMed  CAS  Google Scholar 

  • Trautmann, E., & Kroner-Herwig, B. (2010). A randomized controlled trial of Internet-based self-help training for recurrent headache in childhood and adolescence. Behaviour Research and Therapy, 48(1), 28–37.

    Article  PubMed  Google Scholar 

  • Tsao, J. C. (2006). CAM for pediatric pain: What is state-of-the-research? Evidence-Based Complementary and Alternative Medicine, 3(1), 143–144.

    Article  PubMed  Google Scholar 

  • Tsao, J. C., Meldrum, M., Kim, S. C., Jacob, M. C., & Zeltzer, L. K. (2007). Treatment preferences for CAM in children with chronic pain. Evidence-Based Complementary and Alternative Medicine, 4(3), 367–374.

    Article  PubMed  Google Scholar 

  • Tsao, J. C., & Zeltzer, L. K. (2005). Complementary and alternative medicine approaches for pediatric pain: A review of the state-of-the-science. Evidence-Based Complementary and Alternative Medicine, 2(2), 149–159.

    Article  PubMed  Google Scholar 

  • Turk, D. C., & Flor, H. (1999). Chronic pain: A biobehavioral perspective. In R. J. Gatchel & D. C. Turk (Eds.), Psychosocial factors in pain: Critical perspectives (pp. 18–34). New York: The Guilford Press.

    Google Scholar 

  • Turk, D. C., & Monarch, E. S. (2002). Chronic biopsychosocial perspective on chronic pain. In D. C. Turk & R. J. Gatchel (Eds.), Psychological approaches to pain management: A practitioner’s handbook (2nd ed., pp. 3–29). New York: Guilford Press.

    Google Scholar 

  • Varni, J. W. (1995). Pediatric pain: A decade biobehavioral perspective. Behavioral Therapist, 18, 65–70.

    Google Scholar 

  • Varni, J. W., Blount, R. L., Waldron, S. A., & Smith, A. J. (1995). Management of pain and distress. In M. C. Roberts (Ed.), Handbook of pediatric psychology (2nd ed., pp. 105–123). New York: The Guilford Press.

    Google Scholar 

  • Varni, J. W., Burwinkle, T. M., Katz, E. R., Meeske, K., & Dickinson, P. (2002). The PedsQL in pediatric cancer: Reliability and validity of the Pediatric Quality of Life Inventory Generic Core Scales, Multidimensional Fatigue Scale, and Cancer Module. Cancer, 94(7), 2090–2106.

    Article  PubMed  Google Scholar 

  • Varni, J. W., Burwinkle, T. M., & Lane, M. M. (2005). Health-related quality of life measurement in pediatric clinical practice: An appraisal and precept for future research and application. Health and Quality of Life Outcomes, 3(1), 34.

    Article  PubMed  Google Scholar 

  • Varni, J. W., Rapoff, M. A., Waldron, S. A., Gragg, R. A., Bernstein, B. H., & Lindsley, C. B. (1996a). Chronic pain and emotional distress in children and adolescents. Journal of Developmental and Behavioral Pediatrics, 17(3), 154–161.

    Article  PubMed  CAS  Google Scholar 

  • Varni, J. W., Rapoff, M. A., Waldron, S. A., Gragg, R. A., Bernstein, B. H., & Lindsley, C. B. (1996b). Effects of perceived stress on pediatric chronic pain. Journal of Behavioral Medicine, 19(6), 515–528.

    Article  PubMed  CAS  Google Scholar 

  • Varrassi, G., Muller-Schwefe, G., Pergolizzi, J., Oronska, A., Morlion, B., Mavrocordatos, P., et al. (2010). Pharmacological treatment of chronic pain – The need for CHANGE. Current Medical Research and Opinion, 26(5), 1231–1245.

    Article  PubMed  CAS  Google Scholar 

  • Verdu, B., Decosterd, I., Buclin, T., Stiefel, F., & Berney, A. (2008). Antidepressants for the treatment of chronic pain. Drugs, 68(18), 2611–2632.

    Article  PubMed  CAS  Google Scholar 

  • Vetter, T. R. (2007). A primer on health-related quality of life in chronic pain medicine. Anesthesia and Analgesia, 104(3), 703–718.

    Article  PubMed  CAS  Google Scholar 

  • Vetter, T. R. (2008). A clinical profile of a cohort of patients referred to an anesthesiology-based pediatric chronic pain medicine program. Anesthesia and Analgesia, 106(3), 786–794.

    Article  PubMed  Google Scholar 

  • Vetter, T. R. (2011). Demographics of chronic pain in children. In B. C. McClain & S. Suresh (Eds.), Handbook of pediatric chronic pain: Current science and integrative practice (1st ed.). New York: Springer.

    Google Scholar 

  • von Weiss, R. T., Rapoff, M. A., Varni, J. W., Lindsley, C. B., Olson, N. Y., Madson, K. L., et al. (2002). Daily hassles and social support as predictors of adjustment in children with pediatric rheumatic disease. Journal of Pediatric Psychology, 27(2), 155–165.

    Article  Google Scholar 

  • Walco, G. A., Dworkin, R. H., Krane, E. J., LeBel, A. A., & Treede, R. D. (2010). Neuropathic pain in children: Special considerations. Mayo Clinic Proceedings, 85(3 Suppl), S33–S41.

    Article  PubMed  Google Scholar 

  • Walco, G. A., & Goldschneider, K. R. (Eds.). (2008). Pain in children: A practical guide for primary care (1st ed.). New York: Humana Press.

    Google Scholar 

  • Walco, G. A., Rozelman, H., & Maroof, D. A. (2009). The assessment and management of chronic and recurrent pain in adolescents. In W. T. O’Donohue (Ed.), Behavioral approaches to chronic disease in adolescence: A guide to integrative care (pp. 163–175). New York: Springer.

    Chapter  Google Scholar 

  • Walker, S. M. (2008). Pain in children: Recent advances and ongoing challenges. British Journal of Anaesthesia, 101(1), 101–110.

    Article  PubMed  CAS  Google Scholar 

  • Waterhouse, M., Tsao, J. C., & Zeltzer, L. K. (2009). Commentary on the use of acupuncture in chronic pediatric pain. Journal of Developmental and Behavioral Pediatrics, 30(1), 69–71.

    Article  PubMed  Google Scholar 

  • Waters, E., Stewart-Brown, S., & Fitzpatrick, R. (2003). Agreement between adolescent self-report and parent reports of health and well-being: Results of an epidemiological study. Child: Care, Health and Development, 29(6), 501–509.

    Article  CAS  Google Scholar 

  • Weinshilboum, R. (2003). Inheritance and drug response. The New England Journal of Medicine, 348(6), 529–537.

    Article  PubMed  Google Scholar 

  • White, K. S., & Farrell, A. D. (2006). Anxiety and psychosocial stress as predictors of headache and abdominal pain in urban early adolescents. Journal of Pediatric Psychology, 31(6), 582–596.

    Article  PubMed  Google Scholar 

  • Wiffen, P. J., McQuay, H. J., Edwards, J. E., & Moore, R. A. (2005). Gabapentin for acute and chronic pain. Cochrane Database Syst Rev, (3), CD005452.

    Google Scholar 

  • Wilson, J. F. (2003). Survey of reference ranges and clinical measurements for psychoactive drugs in serum. Therapeutic Drug Monitoring, 25(2), 243–247.

    Article  PubMed  Google Scholar 

  • Winner, P. (2008). Pediatric headache. Current Opinion in Neurology, 21(3), 316–322.

    Article  PubMed  Google Scholar 

  • Winner, P., Pearlman, E. M., Linder, S. L., Jordan, D. M., Fisher, A. C., & Hulihan, J. (2005). Topiramate for migraine prevention in children: A randomized, double-blind, placebo-controlled trial. Headache, 45(10), 1304–1312.

    Article  PubMed  Google Scholar 

  • Youssef, N. N., Murphy, T. G., Langseder, A. L., & Rosh, J. R. (2006). Quality of life for children with functional abdominal pain: A comparison study of patients’ and parents’ perceptions. Pediatrics, 117(1), 54–59.

    Article  PubMed  Google Scholar 

  • Zeltzer, L. K., Bursch, B., & Walco, G. (1997a). Pain responsiveness and chronic pain: A psychobiological perspective. Journal of Developmental and Behavioral Pediatrics, 18(6), 413–422.

    Article  PubMed  CAS  Google Scholar 

  • Zeltzer, L. K., Bush, J. P., Chen, E., & Riveral, A. (1997b). A psychobiologic approach to pediatric pain: Part I. History, physiology, and assessment strategies. Current Problems in Pediatrics, 27(6), 225–253.

    PubMed  CAS  Google Scholar 

  • Zeltzer, L. K., Bush, J. P., Chen, E., & Riveral, A. (1997c). A psychobiologic approach to pediatric pain: Part II. Prevention and treatment. Current Problems in Pediatrics, 27(7), 264–284.

    PubMed  CAS  Google Scholar 

  • Zernikow, B., Michel, E., & Anderson, B. (2007). Transdermal fentanyl in childhood and adolescence: A comprehensive literature review. The Journal of Pain, 8(3), 187–207.

    Article  PubMed  CAS  Google Scholar 

  • Zernikow, B., Michel, E., Craig, F., & Anderson, B. J. (2009). Pediatric palliative care: Use of opioids for the management of pain. Paediatric Drugs, 11(2), 129–151.

    Article  PubMed  Google Scholar 

  • Zhou, S. F. (2009a). Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I. Clinical Pharmacokinetics, 48(11), 689–723.

    Article  PubMed  CAS  Google Scholar 

  • Zhou, S. F. (2009b). Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part II. Clinical Pharmacokinetics, 48(12), 761–804.

    Article  PubMed  CAS  Google Scholar 

  • Zhou, S. F., Liu, J. P., & Chowbay, B. (2009). Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metabolism Reviews, 41(2), 89–295.

    Article  PubMed  CAS  Google Scholar 

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  1. Division of Pain Medicine, Department of Anesthesiology, University of Alabama School of Medicine, 619 South 19th Street, JT-862, Birmingham, AL, 35249-6810, USA

    Thomas R. Vetter MD, MPH

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    Rhonda J. Moore

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Vetter, T.R. (2013). Pediatric Chronic Pain. In: Moore, R.J. (eds) Handbook of Pain and Palliative Care. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1651-8_11

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  • DOI: https://doi.org/10.1007/978-1-4419-1651-8_11

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