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Lipid A in Cancer Therapies Preclinical Results

  • Daniele Reisser
  • Jean-François JeanninEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 667)

Abstract

Studies in animal models showed that the antitumoral effect of LPS and of their biologically active moiety, lipid A, is indirect and relies on the induction of an immune response both innate and specific, leading to cytokine production. They also affect tumor development by inhibiting tumor blood flow and induce necrosis as well as apoptosis of tumor cells. Lipids A have been tested in animals, either alone or as adjuvant in therapeutic vaccines. The efficacy of treatments depends on the type of molecule and on the protocol. In general, increased survival was obtained, accompanied in some cases by tumor regression and cure.

Keywords

Antitumoral Effect Peritoneal Carcinomatosis Cancer Immunol Tumor Cell Injection Synthetic Lipid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2009

Authors and Affiliations

  1. 1.Tumor Immunology and Immunotherapy Laboratory Inserm U866University of BurgundyDijonFrance

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