The Lipid A Receptor

  • Kiyoshi TakedaEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 667)


The lipid A receptor consists of several subunits. Lipopolysaccharide binding protein (LBP) is a serum protein facilitating association of lipid A with CD14. The Lipid A-LBP-CD14 complex is further delivered to Toll-like receptor 4 (TLR4), which is essential for lipid A-mediated cellular activation. TLR4 associates with MD-2, which is required for surface expression and recognition of lipid A. In addition, the RP 10S-MD-1 complex mediates TLR4-mediated response in B cells and negatively regulates TLR4-mediated response in dendritic cells. Thus, lipid A receptor’s function varies among cell populations.


Mouse Peritoneal Macrophage Toll Receptor Therapy Dendritic Cell Human Heat Shock Protein Large Polymeric Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2009

Authors and Affiliations

  1. 1.Department of Molecular GeneticsMedical Institute of Bioregulation, Kyushu UniversityFukuokaJapan

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