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Bacterial Toxins as Immunomodulators

  • Chapter
Pathogen-Derived Immunomodulatory Molecules

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 666))

Abstract

Bacterial toxins are the causative agent of pathology in a variety of diseases. Although not always the primary target of these toxins, many have been shown to have potent immuno-modulatory effects, for example, inducing immune responses to co-administered antigens and suppressing activation of immune cells. These abilities of bacterial toxins can be harnessed and used in a therapeutic manner, such as in vaccination or the treatment of autoimmune diseases. Furthermore, the ability of toxins to gain entry to cells can be used in novel bacterial toxin based immuno-therapies in order to deliver antigens into MHC Class I processing pathways. Whether the immunomodulatory properties of these toxins arose in order to enhance bacterial survival within hosts, to aid spread within the population or is pure serendipity, it is interesting to think that these same toxins potentially hold the key to preventing or treating human disease.

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Authors and Affiliations

  1. Department of Cellular and Molecular Medicine, School of Medicine Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, UK

    David S. Donaldson & Neil A. Williams

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  1. David S. Donaldson
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  2. Neil A. Williams
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Correspondence to Neil A. Williams .

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  1. Inflammation and Immunity Group, Institute of Molecular Medicine, Trinity College, Dublin, Ireland

    Padraic G. Fallon BSc, MSc, PhD

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Donaldson, D.S., Williams, N.A. (2009). Bacterial Toxins as Immunomodulators. In: Fallon, P.G. (eds) Pathogen-Derived Immunomodulatory Molecules. Advances in Experimental Medicine and Biology, vol 666. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1601-3_1

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