FoxO Proteins and Cardiac Pathology

  • Albert Wong
  • Elizabeth A. WoodcockEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 665)


The FoxO family of transcription factors mediate a wide range of cellular responses from cell death to cell survival, growth inhibition and glucose utilization. This complex array of responses is regulated by an equally complex regulatory system, involving phosphorylation, ubiquitinization and acetylation, in addition to interactions with other transcription factors and transcriptional modifiers. In heart, FoxO proteins have been shown to be involved in development, in limiting hypertrophic growth responses and in cardioprotection provided by silent information regulator 1 (Sirt1). However, the range of responses mediated by FoxO proteins and the clear evidence for involvement of FoxO regulators in cardiac pathology, suggest that further pathological actions of FoxO family members remain to be elucidated.


Cardiac Hypertrophy Serum Response Factor Cardiac Pathology cAMP Response Element Binding Protein Forkhead Transcription Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer+Business Media 2009

Authors and Affiliations

  1. 1.Molecular Cardiology LaboratoryBaker IDI Heart and Diabetes InstituteMelbourneAustralia
  2. 2.Department of Biochemistry and Molecular BiologyMonash UniversityClaytonAustralia

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