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FoxO Proteins and Cardiac Pathology

  • Chapter
Forkhead Transcription Factors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 665))

Abstract

The FoxO family of transcription factors mediate a wide range of cellular responses from cell death to cell survival, growth inhibition and glucose utilization. This complex array of responses is regulated by an equally complex regulatory system, involving phosphorylation, ubiquitinization and acetylation, in addition to interactions with other transcription factors and transcriptional modifiers. In heart, FoxO proteins have been shown to be involved in development, in limiting hypertrophic growth responses and in cardioprotection provided by silent information regulator 1 (Sirt1). However, the range of responses mediated by FoxO proteins and the clear evidence for involvement of FoxO regulators in cardiac pathology, suggest that further pathological actions of FoxO family members remain to be elucidated.

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Authors and Affiliations

  1. Molecular Cardiology Laboratory, Baker IDI Heart and Diabetes Institute, PO Box 6492, St. Kilda Road Central, Melbourne, 8008, Victoria, Australia

    Albert Wong & Elizabeth A. Woodcock

  2. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

    Albert Wong

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  1. Albert Wong
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  2. Elizabeth A. Woodcock
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Correspondence to Elizabeth A. Woodcock .

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Editors and Affiliations

  1. Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  2. Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  3. Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  4. Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  5. Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

  6. Institute of Environmental Health Sciences, Wayne State University School of Medicine, Detroit, Michigan, USA

    Kenneth Maiese MD

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Wong, A., Woodcock, E.A. (2009). FoxO Proteins and Cardiac Pathology. In: Maiese, K. (eds) Forkhead Transcription Factors. Advances in Experimental Medicine and Biology, vol 665. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1599-3_6

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