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The Biology of FoxP3: A Key Player in Immune Suppression during Infections, Autoimmune Diseases and Cancer

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 665)

Abstract

The Transcription factor FoxP3belongs to the forkhead/winged-helix familyoftranscriptional regulators and shares general structural features with other FoxP family members. FoxP3 functions as a master of transcription for the development of regulatory T-cells (Treg cells) both in humans and in mice. Natural genetic mutations of FoxP3 that disrupt its function in humans result in an autoimmune syndrome called Immune Polyendocrinopathy, Enteropathy, X-linked (IPEX) and in mice, its deletion causes the Scurfy phenotype, with similar pathology. The finding that FoxP3 is required for the development and function of Tregs has led to an explosion of research in determining its regulation and function in the immune system. Understanding the biological properties of FoxP3 has a wide range of implications for immune tolerance, autoimmune disorders, inflammation and immune response to infectious diseases and cancer.

Keywords

Foxp3 Expression Forkhead Transcription Factor FoxP3 Gene Neonatal Diabetes Mellitus Forkhead Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer+Business Media 2009

Authors and Affiliations

  1. 1.Department of MicrobiologyNew York University School of Medicine, Smilow Research CenterNew YorkUSA
  2. 2.Department of MicrobiologyNYU Cancer InstituteNew YorkUSA
  3. 3.New York University School of MedicineNew YorkUSA

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