FOXL2: At the Crossroads of Female Sex Determination and Ovarian Function

  • Bérénice A. Benayoun
  • Aurélie Dipietromaria
  • Claude Bazin
  • Reiner A. VeitiaEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 665)


The gene FOXL2 encodes a forkhead transcription factor whose mutations are responsible for the blepharophimosis ptosis epicanthus-inversus syndrome. This genetic disorder is characterized by eyelid and mild craniofacial abnormalities often in association with premature ovarian failure. FOXL2 orthologs are found throughout the animal phylum and its sequence is highly conserved in vertebrates. FOXL2 is one ofthe earliest ovarian markers and it offers,along with its targets, a model to study ovarian development and function. In this chapter, we review recent data concerningits mutations, targets, regulation and functions. Studies ofthe cellular consequences ofFOXL2 mutations seem to indicate that aggregation is a common pathogenic mechanism. However, no reliable genotype/phenotype correlation has been established to predict the exact impact ofpoint mutations in the coding region of FOXL2. FOXL2 has been suggested to be involved in the regulation of cholesterol homeostasis, steroid metabolism, apoptosis, reactive oxygen species detoxification and inflammation processes. Interestingly, all these processes are not equally affected by FOXL2 mutations. The elucidation of the impact of the FOXL2 function in the ovary will allow a better understanding of normal ovarian development and function as well as the pathogenic mechanisms underlying BPES.


Premature Ovarian Failure Forkhead Transcription Factor Ovarian Dysfunction Forkhead Domain polyAlanine Tract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer+Business Media 2009

Authors and Affiliations

  • Bérénice A. Benayoun
    • 1
    • 2
  • Aurélie Dipietromaria
    • 1
    • 2
  • Claude Bazin
    • 1
    • 2
  • Reiner A. Veitia
    • 1
    • 2
    Email author
  1. 1.Institut Jacques MonodBâtiment BuffonParis Cx 13France
  2. 2.Université Paris Diderot-Paris 7ParisFrance

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