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The ASCRS Textbook of Colon and Rectal Surgery pp 669–690Cite as

Colorectal Cancer: Epidemiology, Etiology, and Molecular Basis

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Abstract

Colorectal cancer (CRC) is a disease with a major worldwide burden. It is the fourth most frequently diagnosed malignancy in men and third most common in women, with almost one million people developing CRC annually.1 In the world, CRC is the third most common cause of cancer death, responsible for 639,000 deaths annually.2 In the USA, CRC is the third most common cancer in men and women and the second most common cause of cancer death overall, accounting for 11% of cancers diagnosed.3 It was estimated that 147,000 cases were diagnosed in the USA in 2009 and that there were 50,000 deaths from the disease.3

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Authors and Affiliations

  1. Department of Surgery, New York University School of Medicine, New York, NY, USA

    Harvey G. Moore MD, FACS, FASCRS

  2. Department of Surgery, St. Michael’s Hospital, University of Toronto, Toronto, ON, Canada

    Nancy N. Baxter MD, PhD

  3. Department of Colorectal Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA

    Jose G. Guillem MD, PhD

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  1. Harvey G. Moore MD, FACS, FASCRS
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  2. Nancy N. Baxter MD, PhD
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  3. Jose G. Guillem MD, PhD
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Editors and Affiliations

  1. Department of Colon and Rectal Surgery, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA

    David E. Beck MD, FACS, FASCRS

  2. Department of Colorectal Surgery, Lahey Clinic, Tufts University School of Medicine, Burlington, Massachusetts, USA

    Patricia L. Roberts MD, FACS, FASCRS

  3. Section of Colon and Rectal Surgery, Rush Medical Center, Chicago, Illinois, USA

    Theodore J. Saclarides MD, FACS, FASCRS

  4. Department of Surgery, Spectrum Health, Grand Rapids, Michigan, USA

    Anthony J. Senagore MD, FACS, FASCRS

  5. Department of Surgery, UCI Medical Center, Orange, California, USA

    Michael J. Stamos MD, FACS, FASCRS

  6. Department of Colorectal Surgery, Cleveland Clinic Florida, Weston, Florida, USA

    Steven D. Wexner MD, FACS, FASCRS, FRCS, FRCS(Ed)

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Moore, H.G., Baxter, N.N., Guillem, J.G. (2011). Colorectal Cancer: Epidemiology, Etiology, and Molecular Basis. In: Beck, D.E., Roberts, P.L., Saclarides, T.J., Senagore, A.J., Stamos, M.J., Wexner, S.D. (eds) The ASCRS Textbook of Colon and Rectal Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1584-9_38

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