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Hereditary Colorectal Cancer

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Abstract

Colorectal cancer is both a genetic and epigenetic disease. It arises because of an accumulation of genetic and epigenetic abnormalities that perturb gene expression and lead to carcinogenesis within the colorectal mucosa. The classes of genes primarily involved are largely those concerned with regulation of cell growth: tumor suppressor genes and proto-oncogenes, and the average sporadic colorectal cancer has accumulated 90 different mutations.1 Most mutations occur because of the environment. However, about one third of colorectal cancers have a hereditary component. Hereditary colorectal cancer is important because members of affected families can be identified as high risk and be advised to have early, intensive surveillance or even prophylactic surgery, because of the complex, multidisciplinary care the families need, and because of what it teaches about the biology of sporadic colorectal cancer. In this chapter, the syndromes of hereditary colorectal cancer are reviewed.

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Acknowledgment.

This chapter was previously authored by Robin K.S. Phillips and Susann K. Clark (separate ­chapter) and Lawrence C. Rusin and Susan Galandiuk ­(separate ­chapter) in the first edition. The two chapters were merged for this second edition.

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Authors and Affiliations

  1. Department of Colorectal Surgery, Digestive Diseases Institute, Cleveland Clinic Foundation, Cleveland, OH, USA

    James Church MBChB, MMedSci, FRACS

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  1. James Church MBChB, MMedSci, FRACS
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Editors and Affiliations

  1. Department of Colon and Rectal Surgery, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA

    David E. Beck MD, FACS, FASCRS

  2. Department of Colorectal Surgery, Lahey Clinic, Tufts University School of Medicine, Burlington, Massachusetts, USA

    Patricia L. Roberts MD, FACS, FASCRS

  3. Section of Colon and Rectal Surgery, Rush Medical Center, Chicago, Illinois, USA

    Theodore J. Saclarides MD, FACS, FASCRS

  4. Department of Surgery, Spectrum Health, Grand Rapids, Michigan, USA

    Anthony J. Senagore MD, FACS, FASCRS

  5. Department of Surgery, UCI Medical Center, Orange, California, USA

    Michael J. Stamos MD, FACS, FASCRS

  6. Department of Colorectal Surgery, Cleveland Clinic Florida, Weston, Florida, USA

    Steven D. Wexner MD, FACS, FASCRS, FRCS, FRCS(Ed)

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© 2011 ASCRS (American Society of Colon and Rectal Surgeons)

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Church, J. (2011). Hereditary Colorectal Cancer. In: Beck, D.E., Roberts, P.L., Saclarides, T.J., Senagore, A.J., Stamos, M.J., Wexner, S.D. (eds) The ASCRS Textbook of Colon and Rectal Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1584-9_37

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