Skip to main content

Endometriosis

  • Chapter
  • First Online:
  • 3330 Accesses

Abstract

Endometriosis is a disease characterized by the presence of endometrial glands and stroma outside the uterine cavity. It is one of the most common conditions requiring surgery for women during their reproductive years. Endometriosis, while not fatal, may be associated with disabling pain and intractable infertility. The degree of symptoms varies widely and does not always correspond to the extent of pathology encountered at surgery. Small lesions may cause severe pain and infertility, while larger lesions may be asymptomatic and be found only incidentally during surgery for other diagnoses. Diagnosis is typically made or confirmed at laparoscopy or during laparotomy. Colon and rectal surgeons often become involved in the management of patients with intestinal endometriosis. This involvement may occur as a result of a combined procedure with a gynecologist or in the management of an endometrioma masquerading as a neoplastic or inflammatory lesion. Treatment for endometriosis is usually multimodal and may require surgery in those patients with infertility, pelvic pain, obstruction, or a poor response to hormonal suppression. While advances in diagnostic tests and therapy have been made, endometriosis remains a frustrating and incompletely understood disease for both the patient and her physicians.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   229.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Hasson HM. Incidence of endometriosis in diagnostic laparoscopy. J Reprod Med. 1976;16:135–8.

    CAS  PubMed  Google Scholar 

  2. Drake TS, Grunert GM. The unsuspected pelvic factor in the infertility evaluation. Fertil Steril. 1980;34:27–31.

    Article  CAS  Google Scholar 

  3. Houston DE, Noller KL, Melton III J, Selwyn BJ. The epidemiology of pelvic endometriosis. Clin Obstet Gynecol. 1988;31(4):787–800.

    Article  CAS  Google Scholar 

  4. Halme J, Stovall D. Endometriosis and its medical management. In: Walch EE, Zacur HA, editors. Reproductive medicine and surgery. St. Louis: Mosby; 1995. p. 695–710.

    Google Scholar 

  5. Moen MH. Is a long period without childbirth a risk factor for endometriosis? Hum Reprod. 1991;6:1404–7.

    Article  CAS  Google Scholar 

  6. Miyazawa K. Incidence of endometriosis among Japanese women. Obstet Gynecol. 1976;48:407–9.

    CAS  PubMed  Google Scholar 

  7. Ridley JH. The histogenesis of endometriosis. A review of facts and fancies. Obstet Gynecol Surv. 1968;20:1–35.

    Article  Google Scholar 

  8. Sampson JA. Perforating hemorrhagic (chocolate) cysts of the ovary, their importance and especially their relation to pelvic adenomas of endometrial type. Arch Surg. 1921;3:245–323.

    Article  Google Scholar 

  9. Telinde RW, Scott RB. Experimental endometriosis. Am J Obstet Gynecol. 1950;60:1147–73.

    Article  CAS  Google Scholar 

  10. Ridley JH, Edwards KI. Experimental endometriosis in the human. Am J Obstet Gynecol. 1958;76:783–90.

    Article  CAS  Google Scholar 

  11. Simpson JL, Elias S, Malinak LR, Buttram VC. Heritable aspects of endometriosis. 1. Genetic studies. Am J Obstet Gynecol. 1980;137:327–31.

    Article  CAS  Google Scholar 

  12. Dmowski WP, Steele RW, Baker GF. Deficient cellular immunity in endometriosis. Am J Obstet Gynecol. 1981;141:377–83.

    Article  CAS  Google Scholar 

  13. Vigano P, Vercellini P, DiBlasio AM, et al. Deficient anti-endometrium lymphocyte mediated cytotoxicity in patients with endometriosis. Fertil Steril. 1991;56:894–9.

    Article  CAS  Google Scholar 

  14. Oosterlynck DJ, Cornillie FJ, Waer M, et al. Women with endometriosis show a defect in natural killer activity resulting in a decreased cytotoxicity to autologous endometrium. Fertil Steril. 1991;56:45–51.

    Article  CAS  Google Scholar 

  15. Thomas EJ, Cooke ID. Impact of gestrinone on the course of asymptomatic endometriosis. Br Med J. 1987;294:272–4.

    Article  CAS  Google Scholar 

  16. Bergqvist A, Thorbjorn B, Hogstrom L, et al. Effects of triptorelin versus placebo on the symptoms of endometriosis. Fertil Steril. 1998;69:702–8.

    Article  CAS  Google Scholar 

  17. Evers JLH. The second-look laparoscopy for evaluation of the result of medical treatment of endometriosis should not be performed during ovarian suppression. Fertil Steril. 1987;47:502–4.

    Article  CAS  Google Scholar 

  18. Vercillini P, Fedele L, Molteni P, et al. Laparoscopy in the diagnosis of gynecologic chronic pelvic pain. Int J Gynaecol Obstet. 1990;32:261–5.

    Article  Google Scholar 

  19. Koninckx PR, Meuleman C, Demeyere S, et al. Suggestive evidence that pelvic endometriosis is a progressive disease, whereas deeply infiltrating endometriosis is associated with pelvic pain. Fertil Steril. 1991;55:759–65.

    Article  CAS  Google Scholar 

  20. Schulman H, Duvivier R, Blattner P. The uterine contractility index: a research and diagnostic tool in dysmenorrhea. Am J Obstet Gynecol. 1983;145:1049–58.

    Article  CAS  Google Scholar 

  21. Liu DTY, Hitchcock A. Endometriosis: its association with retrograde menstruation, dysmenorrhea and tubal pathology. Br J Obstet Gynecol. 1986;93:859–62.

    Article  CAS  Google Scholar 

  22. Cornillie FJ, Oosterlynck DJ, Lauweryns J, et al. Deeply infiltrating pelvic endometriosis: histology and clinical significance. Fertil Steril. 1990;53:978–93.

    Article  CAS  Google Scholar 

  23. Badaway S, Marshall L, Gabal A, et al. The concentration of 13,14-dihydro-15-keto-prostaglandin F2alpha and prostaglandin E2 in peritoneal fluid of infertile patients with and without endometriosis. Fertil Steril. 1982;38:166–70.

    Article  Google Scholar 

  24. Dawood M, Khan-Dawood F, Wilson L. Peritoneal fluid prostaglandins and prostanoids in women with endometriosis, chronic pelvic inflammatory disease, and pelvic pain. Am J Obstet Gynecol. 1984;148:391–5.

    Article  CAS  Google Scholar 

  25. Hull MGR, Glazener CMA, Kelly NJ, et al. Population study of causes, treatment, and outcome of infertility. Br Med J. 1985;291:1693–7.

    Article  CAS  Google Scholar 

  26. Fortier KJ, Haney AF. The pathologic spectrum of uterotubal junction obstruction. Obstet Gynecol. 1985;65:93–8.

    CAS  PubMed  Google Scholar 

  27. Buttram Jr VC, Reiter RC. Endometriosis. In: Buttram Jr VC, Reiter RC, editors. Surgical treatment of the infertile female. Baltimore: Williams & Wilkins; 1985. p. 89–148.

    Google Scholar 

  28. Garcia CR, David SS. Pelvic endometriosis: infertility and pelvic pain. Am J Obstet Gynecol. 1977;129:740–7.

    Article  CAS  Google Scholar 

  29. Inoue M, Kobayshi Y, Honda I, et al. The impact of endometriosis on the reproductive outcome of infertile patients. Am J Obstet Gynecol. 1992;167:278–82.

    Article  CAS  Google Scholar 

  30. Jansen RPS. Minimal endometriosis and reduced fecundability: prospective evidence from an artificial insemination by donor program. Fertil Steril. 1986;46:141–3.

    Article  CAS  Google Scholar 

  31. Floberg J, Backdahl M, Silfersward C, et al. Postpartum perforation of the colon due to endometriosis. Acta Obstet Gynecol Scand. 1984;63:183–4.

    Article  CAS  Google Scholar 

  32. Prystowsky JB, Stryker SJ, Ujiki GT, Poticha SM. Gastrointestinal endometriosis. Arch Surg. 1988;123:855–8.

    Article  CAS  Google Scholar 

  33. Aure JC, Hoeg K, Kolstad P. Carcinoma of the ovary and endometriosis. Acta Obstet Gynecol Scand. 1971;50:63–7.

    Article  CAS  Google Scholar 

  34. Yantiss RK, Clement PB, Young RH. Neoplastic and pre-neoplastic changes in gastrointestinal endometriosis. Am J Surg Pathol. 2000;24:513–24.

    Article  CAS  Google Scholar 

  35. Kennedy SH, Starkey PM, Sargent I, et al. Anti-endometrial antibodies in endometriosis measured by an enzyme-linked immunosorbent assay before and after treatment with danazol and nafarelin. Obstet Gynecol. 1990;75:914–7.

    CAS  PubMed  Google Scholar 

  36. Chapron C, Dumontier I, Dousset B, et al. Results and role of rectal endoscopic ultrasonography for patients with deep pelvic endometriosis. Hum Reprod. 1998;13:2266–70.

    Article  CAS  Google Scholar 

  37. Doniec JM, Kahlke V, Peetz F, et al. Rectal endometriosis: high sensitivity and specificity of endorectal ultrasound with an impact for the operative management. Dis Colon Rectum. 2003;46:1667–73.

    Article  Google Scholar 

  38. Bazot M, Darai E, Hourani R, et al. Deep pelvic endometriosis: MR imaging for diagnosis and prediction of extension of disease. Radiology. 2004;232:379–89.

    Article  Google Scholar 

  39. Kinkel K, Chapron C, Balleyguier C, et al. Magnetic resonance imaging characteristics of deep endometriosis. Hum Reprod. 1999;14:1080–6.

    Article  CAS  Google Scholar 

  40. Kennedy SH, Soper ND, Mojiminiyi OA. Immunoscintigraphy of endomentriosis. A preliminary study. Br J Obstet Gynecol. 1988;95:693–7.

    Article  CAS  Google Scholar 

  41. Vasquez G, Cornillie FJ, Brosens IO. Peritoneal endometriosis: scanning electron microscopy in visually normal peritoneum. Fertil Steril. 1986;42:696–703.

    Article  Google Scholar 

  42. American Society for Reproductive Medicine. Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril. 1997;67:817–21.

    Article  Google Scholar 

  43. Donnez J, Nisolle M, Casanas-Roux F, et al. Stereometric evaluation of peritoneal endometriosis and endometriotic nodules of the rectovaginal septum. Hum Reprod. 1995;11:224–8.

    Article  Google Scholar 

  44. Koninckx PR. Deeply infiltrating endometriosis. In: Brosens I, Donnez J, editors. Endometriosis: research and management. Carnforth: Parthenon Publishing; 1993. p. 437–46.

    Google Scholar 

  45. Martin DC, Hubert GD, Vander Zwaag R, et al. Laparoscopic appearances of peritoneal endometriosis. Fertil Steril. 1989;51:63–7.

    Article  CAS  Google Scholar 

  46. Koninckx PR, Martin DC. Deep endometriosis: a consequence of infiltration or retraction or possibly adenomyosis externa? Fertil Steril. 1992;58:924–8.

    Article  CAS  Google Scholar 

  47. Vercellini P, Aimi G, Panazza S, et al. A gonadotropin-releasing hormone agonist versus a low-dose oral contraceptive for pelvic pain associated with endometriosis. Fertil Steril. 1992;60:75–9.

    Article  Google Scholar 

  48. Dmowski WP, Radwanska E, Rana N. Recurrent endometriosis following hysterectomy and oophorectomy: the role of residual ovarian fragments. Int J Gynaecol Obstet. 1988;26:93–103.

    Article  CAS  Google Scholar 

  49. Dmowski WP, Gebel H, Braun DP. The role of cell mediated immunity in pathogenesis of endometriosis. Acta Obstet Gynecol Scand. 1994;159:7–14.

    CAS  Google Scholar 

  50. Noble AD, Letchworth AT. Medical treatment of endometriosis: a comparative trial. Postgrad Med J. 1979;55:37–9.

    PubMed  Google Scholar 

  51. Wheeler JM, Knitte JD, Miller JD. Depot Leuprolide versus danazol in treatment of women with symptomatic endometriosis. Am J Obstet Gynecol. 1992;167:1367–71.

    Article  CAS  Google Scholar 

  52. Hall LH, Malone JM, Ginsburg KA. Flare-up of endometriosis induced by gonadotropin-releasing hormone agonist leading to bowel obstruction. Fertil Steril. 1995;64:1204–6.

    Article  CAS  Google Scholar 

  53. Redwine DB. Endometriosis persisting after castration: clinical characteristics and results of surgical management. Obstet Gynecol. 1994;83:405–13.

    CAS  PubMed  Google Scholar 

  54. Olive DL, Lee KL. Analysis of sequential treatment protocols for endometriosis-associated infertility. Am J Obstet Gynecol. 1986;154:613.

    Article  CAS  Google Scholar 

  55. Remorgida V, Ragni N, Ferrero S, et al. How complete is full thickness disc resection of bowel endometriotic lesions? A prospective surgical and histologic study. Hum Reprod. 2005;20:2317–20.

    Article  CAS  Google Scholar 

  56. Nezhat C, Pennington E, Nezhat F, Silfen SL. Laparoscopically assisted anterior rectal wall resection and reanastomosis for deeply infiltrating endometriosis. Surg Laparosc Endosc. 1991;1:106–8.

    Article  CAS  Google Scholar 

  57. Redwine DB, Koning M, Sharpe DR. Laparoscopically assisted transvaginal segmental resection of the rectosigmoid colon for endometriosis. Fertil Steril. 1996;65:193–7.

    Article  CAS  Google Scholar 

  58. Darai E, Ackerman G, Bazot M, et al. Laparoscopic segmental colon resection for endometriosis: limits and complications. Surg Endosc. 2007;21:2039–43.

    Article  CAS  Google Scholar 

  59. Wheeler JM, Malinak LR. Recurrent endometriosis. Contrib Gynecol Obstet. 1987;16:13–21.

    CAS  PubMed  Google Scholar 

  60. Bailey HR, Ott MT, Hartendorp P. Aggressive surgical management for advanced colorectal endometriosis. Dis Colon Rectum. 1994;37:747–53.

    Article  CAS  Google Scholar 

  61. Buttram VC, Reiter RC, Ward SM. Treatment of endometriosis with Danazol: report of a six year prospective study. Fertil Steril. 1985;43:353.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2011 ASCRS (American Society of Colon and Rectal Surgeons)

About this chapter

Cite this chapter

Snyder, M.J. (2011). Endometriosis. In: Beck, D.E., Roberts, P.L., Saclarides, T.J., Senagore, A.J., Stamos, M.J., Wexner, S.D. (eds) The ASCRS Textbook of Colon and Rectal Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1584-9_25

Download citation

  • DOI: https://doi.org/10.1007/978-1-4419-1584-9_25

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-1581-8

  • Online ISBN: 978-1-4419-1584-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics