Case–Control Studies

  • Jørn Olsen
  • Kaare Christensen
  • Jeff Murray
  • Anders Ekbom
Part of the Springer Series on Epidemiology and Public Health book series (SSEH, volume 1)


A follow-up study on chronic diseases usually needs to be large with a long follow-up period to provide a sufficient number of cases to be informative. Most of the participants in the study will provide little information since they will remain disease-free. A case–-control sampling strategy may sometimes be possible and it can usually be conducted at a much lower cost than a follow-up.


Multiple Sclerosis Multiple Sclerosis Patient Source Population Exposure Data Incidence Rate Ratio 
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    Miettinen OS. Subject selection in case-referent studies with a secondary base. J Chronic Dis 1987;40(2):186–187.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Jørn Olsen
    • 1
  • Kaare Christensen
    • 2
  • Jeff Murray
    • 3
  • Anders Ekbom
    • 4
  1. 1.School of Public HealthUniversity of California, Los AngelesLos AngelesUSA
  2. 2.Institute of Public HealthUniversity of Southern DenmarkOdense CDenmark
  3. 3.Department of Pediatrics, 2182 MedLabsUniversity of IowaIowa CityUSA
  4. 4.Department of MedicineKarolinska InstitutetStockholmSweden

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