Genetic Influences on Thyroid Function Tests

  • Wendy M. van der Deure
  • Marco Medici
  • Robin P. Peeters
  • Theo J. Visser
Part of the Thyroid Function Testing book series (ENDO, volume 28)


In this review we will discuss the possible effects of polymorphic variation in the genes important for thyroid hormone synthesis, metabolism, and action, on the interindividual variation in thyroid functions tests. The genes involved are summarized in the following outline of thyroid hormone production and action, but their role is discussed in detail in other sections (Chaps. 1 and 4). In addition to these genes, we will also briefly discuss the possible contribution of genetic variation in the thyroid-specific transcription factors which are known to be important for thyroid development and regulation: TTF1, TTF2, and Pax8.


Thyroid Hormone Congenital Hypothyroidism Thyroid Function Test Thyroid Hormone Concentration Thyroid Hormone Synthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Wendy M. van der Deure
  • Marco Medici
  • Robin P. Peeters
  • Theo J. Visser
    • 1
  1. 1.Department of Internal Medicine, Erasmus MCErasmus University Medical SchoolGE RotterdamThe Netherlands

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