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Cytotoxic/Protective Activity of Nitric Oxide in Cancer

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Nitric Oxide (NO) and Cancer

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Nitric oxide (NO) is an important signaling molecule that plays a significant role in the regulation of cancer biological functions. Accumulating evidences have reported two facets of NO as a possible mediator of cancer development and anti-cancer therapeutics. The paradoxical action of NO in cancer biology depends on concentration, chemical variability, cancer microenvironment, etc. As an anti-cancer therapeutic, NO may be useful as in vivo chemo-sensitizers or radiosensitizers to target chemo- and radioresistant tumors. However, continuous exposure to NO is associated with neoplastic transformation and metastasis through induction of cancer proliferation, invasion, and expression of angiogenic factors. Moreover, recent advances suggest that the expression of iNOS can serve as a prognostic marker. Therefore, an approach to modulate NO production and regulation of signaling pathways for iNOS expression may open up new avenues of research by allowing a potential approach to effective treatment of cancer.

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Authors and Affiliations

  1. Department of Microbiology, Infection Signaling Network Research Center, College of Medicine, Chungnam National University, Daejeon, 301–747, Republic of Korea

    Eun-Kyeong Jo

  2. Department of Microbiology and Immunology, Wonkwang University School of Medicine, Iksan, 570-749, Republic of Korea

    Hyun-Ock Pae

  3. Department of Internal Medicine and Airway Remodeling Laboratory, Chonbuk National University Medical School, Jeonju, 570-752, Republic of Korea

    Yong Chul Lee

  4. School of Biological Sciences, Ulsan University College of Natural Sciences, Daehackrho 102, Namgu, Ulsan, 680-749, Republic of Korea

    Hun-Taeg Chung

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  1. Dept. Microbiology, Immunology &, Molecular Genetics, University of California, Los Angeles, Charles E. Young Dr. E. 609, Los Angeles, 90095, California, USA

    Benjamin Bonavida

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Jo, EK., Pae, HO., Lee, Y.C., Chung, HT. (2010). Cytotoxic/Protective Activity of Nitric Oxide in Cancer. In: Bonavida, B. (eds) Nitric Oxide (NO) and Cancer. Cancer Drug Discovery and Development. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1432-3_7

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