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A Role for eNOS in Oncogenic Ras-Driven Cancer

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Nitric Oxide (NO) and Cancer

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Nitric oxide (NO) is a highly diffusible gas that is generated by the family of nitric oxide synthases and is increasingly associated with tumorigenesis. While both pro- and anti-tumorigenic properties have been ascribed to NO signaling, recent evidence suggests that eNOS or endothelial nitric oxide synthase promotes tumor formation through its effects on proliferation, cell survival, and angiogenesis. In this chapter we discuss recent evidence that eNOS promotes tumorigenic growth through the activation of the Ras family of proteins.

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Authors and Affiliations

  1. Department of Pharmacology and Cancer Biology, Department of Radiation Oncology, Duke University Medical Center, Durham, NC, 27710, USA

    David F. Kashatus & Christopher M. Counter

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  1. David F. Kashatus
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  2. Christopher M. Counter
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Correspondence to Christopher M. Counter .

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  1. Dept. Microbiology, Immunology &, Molecular Genetics, University of California, Los Angeles, Charles E. Young Dr. E. 609, Los Angeles, 90095, California, USA

    Benjamin Bonavida

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Kashatus, D.F., Counter, C.M. (2010). A Role for eNOS in Oncogenic Ras-Driven Cancer. In: Bonavida, B. (eds) Nitric Oxide (NO) and Cancer. Cancer Drug Discovery and Development. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1432-3_2

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