Regulation of Angiogenesis by Macrophages

  • Rajendra S. Apte
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 664)


Abnormal angiogenesis is a cardinal feature in the pathophysiology of several diseases of the retina including retinopathy of prematurity, diabetic retinopathy and choroidal neovascularization associated with age-related macular degeneration. Recent evidence has implicated macrophages as components of the innate immune system that play a key role in regulating angiogenesis in the retina and choroid. This review will focus on the role of macrophages in regulating ocular angiogenesis.


Diabetic Retinopathy Tumor Associate Macrophage Macrophage Polarization Macrophage Phenotype Immune Privilege 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Ophthalmology and Visual Sciences, Developmental Biology, Barnes Retina InstituteWashington University School of MedicineSt. LouisUSA

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