Skip to main content

Medications for ADHD

  • Chapter
  • First Online:
Attention Deficit Hyperactivity Disorder Handbook
  • 4581 Accesses

Abstract

Medications, especially central nervous system stimulants, are an important part of treatment of ADHD. The use of stimulants for the treatment of hyperactive behavior in children was first described in 1937, beginning with amphetamines. Controlled trials of methylphenidate (Ritalin®) in the 1960s demonstrated significant benefits without serious side effects. In addition to a lessening of motor activity, focus and attention were increased and schoolwork, grades, and social behavior were improved. In small to moderate doses, methylphenidate benefits learning without impairing creative or flexible thinking. The value of stimulant medication in the management of ADHD has withstood the test of time.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abramowitz AJ, Dulcan MK, et al. ADHD children’s responses to stimulant medication and two intensities of a behavioral intervention. Beha Modif. 1992;16:193–203.

    Article  CAS  Google Scholar 

  • Ahmann PA, et al. Placebo-controlled evaluation of Ritalin side effects. Pediatrics. 1993;91:1101–1106.

    PubMed  CAS  Google Scholar 

  • Auci DL, et al. Methylphenidate and the immune system (Letter to the editor). J Am Acad Child Adolesc Psychiatry. 1997;36:1015–1016.

    Article  PubMed  CAS  Google Scholar 

  • Barkley RA, Fischer M, Edelbrock CS, Smallish L. The adolescent outcome of hyperactive children diagnosed by research criteria: I. An 8-year prospective follow-up study. J Am Acad Child Adolesc Psychiatry. 1990;29:546–557.

    Google Scholar 

  • Barkley RA, et al. Attention deficit disorder with and without hyperactivity: Clinical response to three dose levels of methylphenidate. Pediatrics. 1991;87:519–531.

    PubMed  CAS  Google Scholar 

  • Barkley RA, et al. Motor vehicle driving competencies and risks in teens and young adults with attention deficit hyperactivity disorder. Pediatrics. 1996;98:1089–1095.

    PubMed  CAS  Google Scholar 

  • Barrickman LL, et al. Bupropion versus methylphenidate in the treatment of attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 1995;34:649–657.

    Article  PubMed  CAS  Google Scholar 

  • Biederman J, et al. Diagnostic continuity between child and adolescent ADHD. J Am Acad Child Adolesc Psychiatry. 1998;37:305–313.

    Article  PubMed  CAS  Google Scholar 

  • Biederman J, Swanson JM, Wigal SB, et al. Efficacy and safety of modafinil film-coated tablets in children and adolescents with attention-deficit/hyperactivity disorders: results of a randomized, double-blind, placebo-controlled, flexible-dose study. Pediatrics. 2005;116:e777–784.

    Google Scholar 

  • Biederman J, Krishnan S, Zhang Y, McGough JJ, Findling RL. Efficacy and tolerability of lisdexamfetamine dimesylate (NRP-104) in children with attention-deficit/hyperactivity disorder: a phase III, multicenter, randomized, double-blind, forced-dose, parallel-group study. Clin Ther. 2007;29:450–463.

    Article  PubMed  CAS  Google Scholar 

  • Bowen J, et al. Stimulant medication and attention-deficit hyperactivity disorder. The child’s perspective. AJDC. 1991;145:291–295.

    PubMed  CAS  Google Scholar 

  • Bradley C. The behavior of children receiving Benzedrine. Am J Psychiatry. 1937;94:577–585.

    Google Scholar 

  • Bradley C. Benzedrine and dexedrine in the treatment of children’s behavior disorders. Pediatrics. 1950;5:24–36.

    PubMed  CAS  Google Scholar 

  • Brown RT, Amler RW, Freeman WS, et al. Treatment of attention-deficit/hyperactivity disorder: overview of the evidence. Pediatrics. 2005;115:e749–757.

    Article  PubMed  Google Scholar 

  • Buitelaar JK, Van der Gaag RJ, Swaab-Barneveld H, Kuiper M. Prediction of clinical response to methylphenidate in children with attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 1995;34:1025–1032.

    Article  PubMed  CAS  Google Scholar 

  • Cantwell DP, Swanson J, Connor DF. Case study: adverse response to clonidine. J Am Acad Child Adolesc Psychiatry. 1997;36:539–544.

    Google Scholar 

  • Casat CD, et al. A double-blind trial of bupropion in children with attention deficit disorder. Psychopharmacol Bull. 1987;23:120–122.

    PubMed  CAS  Google Scholar 

  • Castellanos FX, et al. Controlled stimulant treatment of ADHD and comorbid Tourette’s syndrome: effects of stimulant and dose. J Am Acad Child Adolesc Psychiatry. 1997;36:58.

    Article  Google Scholar 

  • Clay TH, et al. Clinical and neuropsychological effects of the novel antidepressant bupropion. Psychopharmacol Bull. 1988;24:143–148.

    PubMed  CAS  Google Scholar 

  • Conners CK, Eisenberg L. The effects of methylphenidate on symptomatology and learning in disturbed children. Am J Psychiatry. 1963;120:458–464.

    PubMed  CAS  Google Scholar 

  • Cox DJ, Merkel RL, Moore M, et al. Relative benefits of stimulant therapy with OROS methylphenidate versus mixed amphetamine salts extended release in improving the driving performance of adolescent drivers with attention-deficit/hyperactivity disorder. Pediatrics. 2006;118:e704–e710.

    Article  PubMed  Google Scholar 

  • Daviss WB, Patel NC, Robb AS, et al. Clonidine for attention-deficit/hyperactivity disorder: II. ECG changes and adverse events analysis. J Am Acad Child Adolesc Psychiatry. 2008;47:189–198.

    Google Scholar 

  • Denckla MB, Bemporad JR, MacKay MC. Tics following methylphenidate administration. J Am Med Assoc. 1976;235:1349–1351.

    Article  CAS  Google Scholar 

  • Douglas VI, et al. Do high doses of stimulants impair flexible thinking in attention-deficit hyperactivity disorder? J Am Acad Child Adolesc Psychiatry. 1995;34:877–885.

    Article  PubMed  CAS  Google Scholar 

  • DuPaul GJ, Rapport MD. Does methylphenidate normalize the classroom performance of children with attention deficit disorder? J Am Acad Child Adolesc Psychiatry. 1993;32:190–198.

    Article  PubMed  CAS  Google Scholar 

  • Dulcan MK. Treatment of children and adolescents. In: RE Hales, SC Yodofsky, JA Talbott (eds). The American Psychiatric Press Textbook of Psychiatry. 2nd ed. Washington, DC: American Psychiatric Press; 1994:pp 1209–1250

    Google Scholar 

  • Dworkin N. Atomoxetine induced electrocardiographic repolarization changes with palpitations in a child. J Am Acad Child Adolesc Psychiatry. 2005;44:510.

    Article  PubMed  Google Scholar 

  • Feeney DJ, Klykylo WM. Medication-induced seizures (Letter to the editor). J Am Acad Child Adolesc Psychiatry. 1997;36:1018–1019.

    Article  PubMed  CAS  Google Scholar 

  • Feldman H, et al. Methylphenidate in children with seizures and attention-deficit disorder. AJDC. 1989;143:1081–1086.

    PubMed  CAS  Google Scholar 

  • Findling RL, Childress AC, Krishnan S, McGough JJ. Long-term effectiveness and safety of lisdexamfetamine dimesylate in school-aged children with attention-deficit/hyperactivity disorder. CNS Spectr. 2008;13:614–620.

    PubMed  Google Scholar 

  • Funk JB, et al. Attention deficit hyperactivity disorder, creativity, and the effects of methylphenidate. Pediatrics. 1993;91:816–819.

    PubMed  CAS  Google Scholar 

  • Gilbert DL, Wang Z, Sallee FR, et al. Dopamine transporter genotype influences the physiological response to medication in ADHD. Brain. 2006;129:2038–2046.

    Article  PubMed  Google Scholar 

  • Gillberg C, et al. Long-term stimulant treatment of children with attention-deficit hyperactivity disorder symptoms. Arch Gen Psychiatry. 1997;54:857–864.

    Article  PubMed  CAS  Google Scholar 

  • Goldman LS, et al. Diagnosis and treatment of attention-deficit/hyperactivity disorder in children and adolescents. J Am Med Assoc. 1998;279:1100–1107.

    Article  CAS  Google Scholar 

  • Greenhill LL, Muniz R, Ball RR, et al. Efficacy and safety of dexmethylphenidate extended-release capsules in children with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2006;45:817–823.

    Article  PubMed  Google Scholar 

  • Gross-Tsur V, et al. Epilepsy and attention deficit hyperactivity disorder: Is methylphenidate safe and effective? J Pediatr. 1997;130:670–674.

    Article  PubMed  CAS  Google Scholar 

  • Hammer SA, Pasternak JF, Zecker SG, Trommer BL. Stimulant therapy and seizure risk in children with ADHD. Pediatr Neurol. 2001;24:99–102.

    Article  Google Scholar 

  • Handen BL, et al. Prediction of response to methylphenidate among children with ADHD and mental retardation. J Am Acad Child Adolesc Psychiatry. 1994;33:1185–1193.

    Article  PubMed  CAS  Google Scholar 

  • Hochman JA, et al. Exacerbation of autoimmune hepatitis: another hepatotoxic effect of pemoline therapy. Pediatrics. 1998;101:106–108.

    Article  PubMed  CAS  Google Scholar 

  • Hood J, Baird G, Rankin PM, Isaacs E. Immediate effects of methylphenidate on cognitive attention skills of children with attention-deficit-hyperactivity disorder. Dev Med Child Neurol. 2005;47:408–414.

    Article  PubMed  Google Scholar 

  • Jensen PS, et al. Collaborative multimodal treatment study of children with ADHD. Arch Gen Psychiatry. 1997;54:865–870.

    Article  PubMed  Google Scholar 

  • Johnston C, Pelham WE, Hoza J, Sturges J. Psychostimulant rebound in attention deficit disordered boys. J Am Acad Child Adolesc Psychiatry. 1988;27:806–810.

    Article  PubMed  CAS  Google Scholar 

  • Keuthen NJ, et al. Retrospective review of treatment outcome for 63 patients with trichotillomania. Am J Psychiatry. 1998;155:560–561.

    PubMed  CAS  Google Scholar 

  • Kouris S. Methylphenidate-induced obsessive-compulsiveness. J Am Acad Child Adolesc Psychiatry. 1998;37:135.

    Article  PubMed  CAS  Google Scholar 

  • Kratochvil CJ, Wilens TE, Greenhill LL, et al. Effects of long-term atomoxetine treatment for young children with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2006;45:919–927.

    Article  PubMed  Google Scholar 

  • Lopez FA, Ginsberg LD, Arnold V. Effect of lisdexamfetmine dimesylate on parent-rated measures in children aged 6 to 12 years with attention-deficit/hyperactivity disorder: a secondary analysis. Postgrad Med. 2008;120:89–102.

    Article  PubMed  Google Scholar 

  • Malhotra S, Santosh PJ. An open clinical trial of buspirone in children with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 1998;37:364–371.

    Article  PubMed  CAS  Google Scholar 

  • Mannuzza S, et al. Adult psychiatric status of hyperactive boys grown up. Am J Psychiatry. 1998;155:493–498.

    PubMed  CAS  Google Scholar 

  • Marcus SC, Wan GJ, Kemner JE, Olfson M. Continuity of methylphenidate treatment for attention-deficit/hyperactivity disorder. Arch Pediatr Adolesc Med. 2005;159:572–578.

    Article  PubMed  Google Scholar 

  • Martin A, Scahill L, Vitulano L, King RA. Stimulant use and trichotillomania. J Am Acad Child Adolesc Psychiatry. 1998;37:349–350.

    Google Scholar 

  • McBride MC, et al. Use of Ritalin in the hyperactive patient with seizures controlled by anticonvulsant drugs. Ann Neurol. 1986;20:428.

    Google Scholar 

  • McGough JJ, Biederrman J, Wigal SB, et al. Long-term tolerability and effectiveness of once-daily mixed amphetamine salts (Aderrall XR) in children with ADHD. J Am Acad Child Adolesc Psychiatry. 2005;44:530–538.

    Article  PubMed  Google Scholar 

  • Millichap JG, et al. Hyperkinetic behavior and learning disorders: III. Battery of neuropsychological tests in controlled trial of methylphenidate. Am J Dis Child. 1968;116:235–244.

    PubMed  CAS  Google Scholar 

  • Millichap JG. Drugs in management of minimal brain dysfunction. Ann N Y Acad Sci. 1973;205:321–334.

    Article  PubMed  CAS  Google Scholar 

  • Millichap JG (Ed). Learning Disabilities and Related Disorders: Facts and Current Issues. Chicago, IL: Year Book Medical Publishers; 1977.

    Google Scholar 

  • Millichap JG. Usage of CNS stimulants for ADHD by pediatric neurologists. Ped Neur Briefs. 1996;10:65.

    Google Scholar 

  • Millichap JG. Progress in Pediatric Neurology III. Chicago, IL: PNB Publishers; 1997a.

    Google Scholar 

  • Millichap JG. Medication-induced seizures in ADHD. Ped Neur Briefs. 1997b;11:63, May.

    Google Scholar 

  • Millichap MG. Locus of control in children with ADHD. Personal communication. 1998.

    Google Scholar 

  • Millichap JG, Swisher CN. Ritalin-induced seizures in two children with ADHD. Ped Neur Briefs. 1997;11:38, May.

    Google Scholar 

  • Miyazaki M, Ito H, Saijo T, et al. Favorable response of ADHD with giant SEP to extended-release valproate. Brain Dev. 2006;28:470–472.

    Article  PubMed  Google Scholar 

  • Mosholder AD, Gelperin K, Hammad TA, Phelan K, Johann-Liang R. Hallucinations and other psychotic symptoms associated with the use of attention-deficit/hyperactivity disorder drugs in children. Pediatrics. 2009;123:611–616.

    Article  PubMed  Google Scholar 

  • Musten LM, et al. Effects of methylphenidate on preschool children with ADHD: cognitive and behavioral functions. J Am Acad Child Adolesc Psychiatry. 1997;36:1407–1415.

    Article  PubMed  CAS  Google Scholar 

  • National Institute of Mental Health. Multimodal Treatment Study of ADHD follow-up: 24-month outcomes of treatment strategies for attention-deficit/hyperactivity disorder. Pediatrics. 2004;113:754–761.

    Article  Google Scholar 

  • Nolan EE, Gadow KD. Children with ADHD and tic disorder and their classmates: behavioral normalization with methylphenidate. J Am Acad Child Adolesc Psychiatry. 1997;36:597–604.

    Article  PubMed  CAS  Google Scholar 

  • O‘Toole K, Abramowitz A, Morris R, Dulcan M. Effects of methylphenidate on attention and nonverbal learning in children with attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 1997;36:531–538.

    Article  PubMed  Google Scholar 

  • Poulton A. Growth on stimulant medication; clarifying the confusion: a review. Arch Dis Child. 2005;90:801–806.

    Article  PubMed  CAS  Google Scholar 

  • Rajesh AS, Bates G, Wright JGC. Atomoxetine-induced electrocardiogram changes. Arch Dis Child. 2006;91:1023–1024.

    Article  PubMed  CAS  Google Scholar 

  • Rapport MD, et al. Attention deficit disorder and methylphenidate: Normalization rates, clinical effectiveness, and response prediction in 76 children. J Am Acad Child Adolesc Psychiatry. 1994;33:882–893.

    Article  PubMed  CAS  Google Scholar 

  • Rapport MD, Denney C. Titrating methylphenidate in children with attention-deficit/hyperactivity disorder: Is body mass predictive of clinical response? J Am Acad Child Adolesc Psychiatry. 1997;36:523–530.

    Article  PubMed  CAS  Google Scholar 

  • Riggs PD. Approach to treatment of ADHD in adolescents with substance use disorders and conduct disorder. J Am Acad Child Adolesc Psychiatry. 1998;37:331–332.

    Article  PubMed  CAS  Google Scholar 

  • Rosh JR, et al. Four cases of severe hepatotoxicity associated with pemoline: Possible autoimmune pathogenesis. Pediatrics. 1998;101:921–923.

    Article  PubMed  CAS  Google Scholar 

  • Safer D, et al. Depression of growth in hyperactive children on stimulant drugs. N Engl J Med. 1972;287:217.

    Article  PubMed  CAS  Google Scholar 

  • Safer DJ, et al. Increased methylphenidate usage for attention deficit disorder in the 1990s. Pediatrics. 1996;98:1084–1088.

    PubMed  CAS  Google Scholar 

  • Satterfield JH, Cantwell DP, Schell A, Blaschke T. Growth of hyperactive children treated with methylphenidate. Arch Gen Psychiatry. 1979;36:212–217.

    Google Scholar 

  • Schachar RJ, et al. Behavioral, situational, and temporal effects of treatment of ADHD with methylphenidate. J Am Acad Child Adolesc Psychiatry. 1997;36:754–763.

    Article  PubMed  CAS  Google Scholar 

  • Shevell M, Schreiber R. Pemoline-associated hepatic failure: a critical analysis of the literature. Pediatr Neurol. 1997;16:14–16.

    Article  PubMed  CAS  Google Scholar 

  • Silva RR, et al. Carbamazepine use in children and adolescents with features of attention-deficit hyperactivity disorder: a meta-analysis. J Am Acad Child Adolesc Psychiatry. 1996;35:352–358.

    Article  PubMed  CAS  Google Scholar 

  • Silva R, Muniz R, McCague K, Childress A, Brams M, Mao A. Treatment of children with attention-deficit/hyperactivity disorder: Results of a randomized, multicenter, double-blind, crossover study of extended-release D-methylphenidate and D,L-methylphenidate and placebo in a laboratory classroom setting. Psychopharmacol Bull. 2008;41:19–33.

    PubMed  Google Scholar 

  • Simeon JG, et al. Bupropion effects in attention deficit and conduct disorders. Can J Psych. 1986;31:581–585.

    CAS  Google Scholar 

  • Smith BH, et al. Equivalent effects of stimulant treatment for attention-deficit hyperactivity disorder during childhood and adolescence. J Am Acad Child Adolesc Psychiatry. 1998;378:314–321.

    Article  Google Scholar 

  • Spencer T, et al. Bupropion exacerbates tics in children with attention deficit hyperactivity disorder and Tourette’s syndrome. J Am Acad Child Adolesc Psychiatry. 1993;32:211–214.

    Article  PubMed  CAS  Google Scholar 

  • Spencer T, et al. Pharmacotherapy of ADHD reviewed. J Am Acad Child Adolesc Psychiatry. 1996;35:409–432.

    Article  PubMed  CAS  Google Scholar 

  • Spencer TJ, Faraone SV, Biederman J, et al. Does prolonged therapy with long-acting stimulant suppress growth in children with ADHD? J Am Acad Child Adolesc Psychiatry. 2006;45:527–537.

    Article  PubMed  Google Scholar 

  • Sprague R, Sleator E. Methylphenidate in hyperkinetic children: Differences in dose effects on learning and social behavior. Science. 1977;198:1274–1276.

    Article  PubMed  CAS  Google Scholar 

  • Stein MA, et al. Methylphenidate dosing: twice daily versus three times daily. Pediatrics. 1996;98:748–756.

    PubMed  CAS  Google Scholar 

  • Swanson JM, et al. Analog classroom assessment of Adderall in children with ADHD. J Am Acad Child Adolesc Psychiatry. 1998;37:519–526, May.

    Article  PubMed  CAS  Google Scholar 

  • Swartwood MO, et al. Methylphenidate effects on EEG, behavior, and performance in boys with ADHD. Pediatr Neurol. 1998;18:244–250.

    Article  PubMed  CAS  Google Scholar 

  • Tannock R, Schachar RJ, Carr RP, Logan GD. Dose response effects of methylphenidate on academic performance and overt behavior in hyperactive children. Pediatrics. 1989;84:648–657.

    Google Scholar 

  • Volkow ND, Fowler JS, Logan J, et al. Effects of modafinil on dopamine and dopamine transporters in the male human brain. J Am Med Assoc. 2009;301:1148–1154.

    Article  CAS  Google Scholar 

  • Waring ME, Lapane KL. Overweight in children and adolescents in relation to attention-deficit/hyperactivity disorder: Results from a national sample. Pediatrics. 2008;12:e1–e5.

    Article  Google Scholar 

  • Whalen CK, et al. Does stimulant medication improve the peer status of hyperactive children? J Consult Clin Psychol. 1989;57:5435–5449.

    Google Scholar 

  • Whalen CK, Henker B, et al. Natural social behaviors in hyperactive children: Dose effects of methylphenidate. J Consult Clin Psychol. 1987;55:187–193.

    Article  PubMed  CAS  Google Scholar 

  • Wilens TE, et al. Cardiovascular effects of therapeutic doses of tricyclic antidepressants in children and adolescents. J Am Acad Child Adolesc Psychiatry. 1996;35:1491–1501.

    Article  PubMed  CAS  Google Scholar 

  • Wilens TE, McBurnett K, Bukstein O, et al. Multisite controlled study of OROS methylphenidate in the treatment of adolescents with attention-deficit/hyperactivity disorder. Arch Pediatr Adolesc Med. 2006;160:82–90.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Millichap, J.G. (2010). Medications for ADHD. In: Attention Deficit Hyperactivity Disorder Handbook. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1397-5_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4419-1397-5_9

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-1396-8

  • Online ISBN: 978-1-4419-1397-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics