Cardiovascular Disease and Neurocognitive Function

  • Shari R. Waldstein
  • Carrington Rice Wendell
  • Megan M. Hosey
  • Stephen L. Seliger
  • Leslie I. Katzel


Cardiovascular (CV) diseases confer substantial increase in risk for ischemic and hemorrhagic stroke. Yet, outside the context of clinical stroke, the brain is an under-recognized target organ of a spectrum of CV diseases. Although it has long been known that CV risk factors and diseases contribute to the development of vascular dementia, we now know that similar risk is conferred for Alzheimer’s disease. Importantly, long before clinical manifestations of stroke or dementia are apparent, CV risk factors and diseases negatively impact the brain and neurocognitive function. We suggest that there is a continuum of neurocognitive and neurobiological impairment associated with increasingly severe manifestations of CV disease across the life span. Here we provide a broad overview of current knowledge pertaining to the relation of CV risk factors and diseases to dementia, neurocognitive function, and the brain.


Atrial Fibrillation Cognitive Decline Pulse Wave Velocity Coronary Artery Bypass Grafting Surgery APOE Genotype 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Preparation of this chapter was supported, in part, by NIH grant 2RO1 AG015112 to SRW.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Shari R. Waldstein
    • 1
    • 2
    • 3
  • Carrington Rice Wendell
    • 1
  • Megan M. Hosey
    • 1
  • Stephen L. Seliger
    • 4
  • Leslie I. Katzel
    • 5
    • 3
  1. 1.Department of PsychologyUniversity of Maryland, Baltimore CountyBaltimoreUSA
  2. 2.Division of Gerontology and Geriatric Medicine, Department of Medicine, School of MedicineUniversity of MarylandBaltimoreUSA
  3. 3.Geriatric Research Education and Clinical CenterBaltimore Veterans Affairs Medical CenterBaltimoreUSA
  4. 4.Division of Nephrology, Department of Medicine, School of MedicineUniversity of MarylandBaltimoreUSA
  5. 5.Division of Gerontology, Department of Medicine, School of MedicineUniversity of MarylandBaltimoreUSA

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