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The Toxic Effects of Formaldehyde on the Nervous System

  • Ahmet SongurEmail author
  • Oguz Aslan Ozen
  • Mustafa Sarsilmaz
Chapter
Part of the Reviews of Environmental Contamination and Toxicology book series (RECT, volume 203)

Abstract

Formaldehyde (FA) (formula: HCHO; IUPAC name: metanal) is a member of the aldehyde family and is one of the simplest organic molecules. FA is an irritating, colorless gas that has a pungent smell (Franklin et al. 2000; Smith 1992; Songur et al. 2003; Yamato et al. 2005). It is rarely found in its original state because it has a short half-life in air and decomposes in light to form a toxic substance. FA is highly soluble in water, as well as in most organic solvents, and is a highly reactive molecule that can be irritating to tissues through direct contact. Furthermore, FA causes cytotoxicity through the formation of strong DNA–protein cross-links, as well as cross-links with other molecules, e.g., amino acids (Cheng et al. 2003; Gurel et al. 2005; Metz et al. 2004).

Keywords

Dentate Gyrus Neurotoxic Effect Caffeic Acid Phenethyl Ester Early Postnatal Period Pyramidal Cell Layer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Ahmet Songur
    • 1
    Email author
  • Oguz Aslan Ozen
    • 2
  • Mustafa Sarsilmaz
    • 3
  1. 1.Department of AnatomySchool of Medicine, University of KocatepeAfyonkarahisarTurkey
  2. 2.Department of AnatomySchool of Medicine, University of Namik KemalTekirdagTurkey
  3. 3.Department of AnatomySchool of Medicine, University of FiratElazigTurkey

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