The Toxic Effects of Formaldehyde on the Nervous System

  • Ahmet SongurEmail author
  • Oguz Aslan Ozen
  • Mustafa Sarsilmaz
Part of the Reviews of Environmental Contamination and Toxicology book series (RECT, volume 203)


Formaldehyde (FA) (formula: HCHO; IUPAC name: metanal) is a member of the aldehyde family and is one of the simplest organic molecules. FA is an irritating, colorless gas that has a pungent smell (Franklin et al. 2000; Smith 1992; Songur et al. 2003; Yamato et al. 2005). It is rarely found in its original state because it has a short half-life in air and decomposes in light to form a toxic substance. FA is highly soluble in water, as well as in most organic solvents, and is a highly reactive molecule that can be irritating to tissues through direct contact. Furthermore, FA causes cytotoxicity through the formation of strong DNA–protein cross-links, as well as cross-links with other molecules, e.g., amino acids (Cheng et al. 2003; Gurel et al. 2005; Metz et al. 2004).


Dentate Gyrus Neurotoxic Effect Caffeic Acid Phenethyl Ester Early Postnatal Period Pyramidal Cell Layer 
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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Ahmet Songur
    • 1
    Email author
  • Oguz Aslan Ozen
    • 2
  • Mustafa Sarsilmaz
    • 3
  1. 1.Department of AnatomySchool of Medicine, University of KocatepeAfyonkarahisarTurkey
  2. 2.Department of AnatomySchool of Medicine, University of Namik KemalTekirdagTurkey
  3. 3.Department of AnatomySchool of Medicine, University of FiratElazigTurkey

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