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The Development of IPV

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History of Vaccine Development

Abstract

Jonas Salk died on 23 June 1995, and so is prevented from writing about the ­development of what he called “non-infectious polio vaccine”. My credentials to undertake the task are not perfect. I never worked for Jonas directly and by the time I reached Toronto to take up a Research Fellowship in Virus Diseases under the directions of Dr. Andrew Rhodes at the Hospital for Sick Children in September 1954, the Francis Trial of injectable polio vaccine (IPV) was already in progress.

Toronto, at the time of working for Andrew Rhodes, was an excellent place to observe the development of both IPV and oral polio vaccine (OPV). Rhodes in 1947 had set up a polio research unit at the Connaught Laboratories associated with the School of Hygiene of the University of Toronto. This unit was to play a decisive role in the development of IPV.

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References

  1. Kolmer JA. Vaccination against acute anterior poliomyelitis. Am J Public Health 1936;26:125–35

    Google Scholar 

  2. Brodie M, Park WH. Active immunisation against poliomyelitis. Am J Public Health 1936;26:119–25

    Article  CAS  Google Scholar 

  3. Sabin AB, Olitsky PK. Cultivation of poliomyelitis virus in human embryonic nervous tissue. Proc Soc Exp Biol Med 1936;31:357–9

    Google Scholar 

  4. Burnet FM, McNamara J. Immunological differences between strains of poliomyelitis virus. Br J Ex Path 1931;12:57–61

    Google Scholar 

  5. Enders JF, Weller TH, Robbins FC. Cultivation of the Lansing strain of poliomyelitis virus in cultures of various human embryonic tissues. Science 1949;109:234–45

    Article  Google Scholar 

  6. Bodian D. Morgan IM, Howe HA. Differentiation of types of poliomyelitis viruses; the grouping of fourteen strains into three basic immunologic types. Am J Hyg 1949;49:234–45

    PubMed  CAS  Google Scholar 

  7. Salk J. Poliomyelitis Vaccine in the fall of 1955. Am J Public Health 1956;46:1–14

    Article  CAS  Google Scholar 

  8. Van Riper HE. Progress in the control of paralytic poliomyelitis through vaccination. Can J Public Health 1955;46:427–48

    Google Scholar 

  9. Morgan JF, Morton HJ, Parker RC. Nutrition of animal cells in tissue culture. 1. Initial studies on a synthetic medium. Proc Soc Exp Biol and Med 1950;73:1–8

    Google Scholar 

  10. Maitland HB, Maitland MC. Cultivation of vaccinia virus without tissue culture. Lancet 1928;2:596–7

    Google Scholar 

  11. Wood W, Shimada FT. Isolation of strains of Virus B from tissue cultures of cynomolgus and rhesus kidney. Can J Publ Hlth 1954;45:509–18

    CAS  Google Scholar 

  12. Farrell LN, Wood W, Franklin RE, Shimada F, Macmorine H, Rhodes AJ. Cultivation of poliomyelitis virus in tissue culture: VI methods for quantity production of poliomyelitis viruses in cultures of monkey kidney. Can J Public Health 1953;44:273–80

    PubMed  CAS  Google Scholar 

  13. Francis TM Jr, Napier JA, Voight RB et al. Evaluation of the 1954 field trial of poliomyelitis vaccine. Final Report Ann Arbor University of Michigan 1957

    Google Scholar 

  14. Fantes KH. Concentrations and partial purification of poliomyelitis viruses. J Hygiene 1962;60:123–33

    Article  CAS  Google Scholar 

  15. LeBouvier GL. The D to C change in poliovirus particles. Br J Exper Path 1959;40:605–20

    CAS  Google Scholar 

  16. Beale AJ. The D-antigen content in polio vaccine as a measure of potency. Lancet 1961;2:1166–8

    Google Scholar 

  17. Hull R, Minner JR, Mascoli GC. New agents recovered from tissue culture of monkey kidney cells: III Recovery of additional agents both from cultures of monkey kidney tissues and directly from tissues and excreta. Am J Hyg 1959;68:31–44

    Google Scholar 

  18. Sweet DH, Hilleman MR. The vacoulating virus, SV40. Proc Soc Exp Biol Med 1960;105:420–7

    Google Scholar 

  19. Van Wesel AL4, van Steenis G, van der Marel P, Osterhouse ADM. Inactivated poliovirus ­vaccine: current production methods and new developments. Rev Infect Dis 1984; 6 (suppl 2):335–40

    Google Scholar 

  20. Montagnon B, Fanget B, Vincent-Falguet JC. Industrial scale production of inactivated ­poliovirus vaccine prepared by culture of Vero cells and microcarriers. Rev Infect Dis 1984;6S:341–4

    Google Scholar 

  21. Beale AJ, Mason PJ, The measurement of D-antigen in poliovirus preparations. J Hyg 1962;60 :113–21

    Article  CAS  Google Scholar 

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Beale, A.J. (2011). The Development of IPV. In: Plotkin, S. (eds) History of Vaccine Development. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1339-5_20

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