The History of Pertussis Vaccination: From Whole-Cell to Subunit Vaccines

  • Marta Granström


A review of all studies and trials cannot be made in this context, but two sources are recommended, i.e., Whooping cough by Joseph E. Lapin [1] and a review by Fine and Clarkson [2]. In the early years of the twentieth century, attempts were made to develop whole-cell vaccines, but for these early studies, the current definition of vaccination may not be valid since many workers have considered prophylaxis to include preventive treatment in the incubation period of the disease, as noted by Lapin.


Vaccine Efficacy Pertussis Toxin Subunit Vaccine Pertussis Vaccine Whooping Cough 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Lapin JH. Whooping Cough. Springfield, III: Charles C Thomas, 1943Google Scholar
  2. 2.
    Finw PEM, Clarkson JA. Reflections on the efficacy of pertussis vaccines. Rev Infect Dis 1987;9:866–83CrossRefGoogle Scholar
  3. 3.
    Madsen T. Vaccination against whooping cough. JAMA 1933; 101:187–188Google Scholar
  4. 4.
    Rasmussen RK. Om kighoste og kighostevaccination i Ejde lægedistrikt paa Færøerne. Bibliot f læger 1925; 131–148Google Scholar
  5. 5.
    Kofoed SE. Nogle oplysninger om optræ af kighoste i Sandø præld (Færøerne) 1923–24 ­speceilt med henblik paa anvendelse af kighostevaccin. Ugesk f lœger 1926; 88:585–588Google Scholar
  6. 6.
    Medical Research Council. The prevention of whooping-cough by vaccination. Br Med J 1951; 1:1463–1471CrossRefGoogle Scholar
  7. 7.
    Medical Research Council. Vaccination against whooping-cough. Relation between protection of children and results of laboratory tests. Br Med J 1956; 2:454–462Google Scholar
  8. 8.
    Medical Research Council. Vaccination against whooping cough. Br Med J 1959; 1:994–1000CrossRefGoogle Scholar
  9. 9.
    International Symposium on Pertussis Vaccine Trials. Trial synopsis, 1995Google Scholar
  10. 10.
    Romanus V, Jonsell R, Berquist SO. Pertussis in Sweden after the cessation of general immunization in 1979. Pediatr Infect Dis J 1987;6:364–371PubMedGoogle Scholar
  11. 11.
    Griffith AH. Permanent brain damage and pertussis vaccination: is the end of the saga in sight? Vaccine 1989; 7:199–210PubMedCrossRefGoogle Scholar
  12. 12.
    Wardlaw AC Parton R. Pathogenesis and Immunity in Pertussis. Chichester: John Wiley & Sons Ltd, 1988Google Scholar
  13. 13.
    Cody CL, Baraff LJ, Cherry JD, Marcy SM, Manclark CR. Nature and rates of adverse reactions associated with DTP and DT immunizations in infants and children. Pediatrics 1981; 68:650–660PubMedGoogle Scholar
  14. 14.
    Pitman M. Pertussis toxin: the cause of the harmful effects and prolonged immunity of whooping cough. A hypothesis. Rev Infec Dis 1979; 1:401–412Google Scholar
  15. 15.
    Robbins JB, Pittman M, Trollfors B, Lagergård TA, Taranger J, Schneerson R. Primum non noncore: a pharmacologically inert pertussis toxoid alone should be the next pertussis vaccine. Pediatr Infect Dis J 1993; 12:795–807PubMedCrossRefGoogle Scholar
  16. 16.
    Sato Y, Kimura M, Fukumi H. Development of a pertussis component vaccine in Japan. Lancet 1984;1:122–126PubMedCrossRefGoogle Scholar
  17. 17.
    Ad hoc group for the study of pertussis vaccines. Placebo-controlled trial of the two ­acellular pertussis vaccines in Sweden – protective efficacy and adverse events. Lancet 1988; 1:955–960Google Scholar
  18. 18.
    Blackwelder WC, Storsæter J, Olin P, Hallander HO. Acellular pertussis vaccines. Efficacy and evaluation of case definitions. AJDC 1991; 145:1285–1289Google Scholar
  19. 19.
    Tuomanen E. Piracy of adhesions: attachment of superinfecting pathogens to respiratory cilia by secreted adhesins of Bordetella pertussis. Infect Immun 1986; 54:905–8Google Scholar
  20. 20.
    Granström M, Olinder-Nielsen AM, Holmblad P, Mark A, Hanngren K. Specific immunoglobulin for treatment of whooping cough. Lancet 1991; 338:1230–1233PubMedCrossRefGoogle Scholar
  21. 21.
    Granström M, Granström G. Serological correlates in whooping cough. Vaccine 1993; 11:445–448PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Clinical MicrobiologyKarolinska HospitalStockholmSweden

Personalised recommendations