Abstract
Topical therapies may be used for treating mild to moderate acne. In the recent years, antibiotics, especially tetracyclines, have been used for the treatment of acne. For very severe cases, isotretinoin is still probably the therapy of choice. Photodynamic therapy (PDT) may be an alternative to antibiotic treatment in selected cases. However, the exact treatment scheme is not established yet. We know neither the relevant concentration of the prodrug nor the proper intensity of the light or the total light dose. PDT may be used in selected cases, but much more research has to be done before PDT of acne can be used in routine clinical practice.
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References
Sigurdsson V, Knulst AC, van Weelden H. Phototherapy of acne vulgaris with visible light. Dermatology. 1997;194:256–60.
Leyden JJ, McGinley K, Mills OH, et al. Topical antibiotics and topical antimicrobial agents in acne therapy. Acta Derm Venereol Suppl (Stockh). 1980;Suppl 89:75–82.
Leyden JJ, Shalita AR. Rational therapy for acne vulgaris: an update on topical treatment. J Am Acad Dermatol. 1986;15:907–15.
Leyden JJ, McGinley KJ, Cavalieri S, et al. Propionibacterium acnes resistance to antibiotics in acne patients. J Am Acad Dermatol. 1983;8:41–5.
Oprica C, Emtestam L, Lapins J, et al. Antibiotic-resistant Propionibacterium acnes on the skin of patients with moderate to severe acne in Stockholm. Anaerobe. 2004;10:155–64.
Eady EA, Gloor M, Leyden JJ. Propionibacterium acnes resistance: a worldwide problem. Dermatology. 2003;206:54–6.
Batt AL, Bruce IB, Aga DS. Evaluating the vulnerability of surface waters to antibiotic contamination from varying wastewater treatment plant discharges. Environ Pollut. 2006;142:295–302.
Kong WD, Zhu YG, Fu BJ, et al. The veterinary antibiotic oxytetracycline and Cu influence functional diversity of the soil microbial community. Environ Pollut. 2006;143:129–37.
Pillsbury DM, Shelly WB, Kligman A. A manual of cutaneous medicine, vol. 1. Philadelphia: WB Saunders; 1961.
O’Brien SC, Lewis JB, Cunliffe WJ. The Leeds revised acne grading system. J Dermatol Treat. 1998;9:215–20.
Eady EA, Cove JH. Is acne an infection of blocked pilosebaceous follicles? Implications for antimicrobial treatment. Am J Clin Dermatol. 2000;1:201–9.
Cunliffe WJ, Holland DB, Jeremy A. Comedone formation: etiology, clinical presentation, and treatment. Clin Dermatol. 2004;22:367–74.
Tan HH. Topical antibacterial treatments for acne vulgaris: comparative review and guide to selection. Am J Clin Dermatol. 2004;5:79–84.
Tappeiner H, Jesionek A. Therapeutische versuche mit fluoreszierenden stoffen. Münch Med Wochenschr. 1903;47:2042–4.
Divaris DX, Kennedy JC, Pottier RH. Phototoxic damage to sebaceous glands and hair follicles of mice after systemic administration of 5-aminolevulinic acid correlates with localized protoporphyrin IX fluorescence. Am J Pathol. 1990;136:891–7.
Peng Q, Soler AM, Warloe T, et al. Selective distribution of porphyrins in skin thick basal cell carcinoma after topical application of methyl 5-aminolevulinate. J Photochem Photobiol B. 2001;62:140–5.
Sandberg C, Halldin CB, Ericson MB, et al. Bioavailability of aminolaevulinic acid and methylaminolaevulinate in basal cell carcinomas: a perfusion study using microdialysis in vivo. Br J Dermatol. 2008;159:1170–6.
Ericson MB, Sandberg C, Stenquist B, et al. Photodynamic therapy of actinic keratosis at varying fluence rates: assessment of photobleaching, pain and primary clinical outcome. Br J Dermatol. 2004;151: 1204–12.
Ashkenazi H, Malik Z, Harth Y, et al. Eradication of Propionibacterium acnes by its endogenic porphyrins after illumination with high intensity blue light. FEMS Immunol Med Microbiol. 2003;35:17–24.
Redondo P, Marquina M, Pretel M, et al. Methyl-ALA-induced fluorescence in photodynamic diagnosis of basal cell carcinoma prior to Mohs micrographic surgery. Arch Dermatol. 2008;144:115–7.
Cunliffe WJ, Goulden V. Phototherapy and acne vulgaris. Br J Dermatol. 2000;142:855–6.
Hongcharu W, Taylor CR, Chang Y, et al. Topical ALA-photodynamic therapy for the treatment of acne vulgaris. J Invest Dermatol. 2000;115:183–92.
Pollock B, Turner D, Stringer MR, et al. Topical aminolaevulinic acid-photodynamic therapy for the treatment of acne vulgaris: a study of clinical efficacy and mechanism of action. Br J Dermatol. 2004;151:616–22.
Wiegell SR, Wulf HC. Photodynamic therapy of acne vulgaris using 5-aminolevulinic acid versus methyl aminolevulinate. J Am Acad Dermatol. 2006;54:647–51.
Horfelt C, Funk J, Frohm-Nilsson M, et al. Topical methyl aminolaevulinate photodynamic therapy for treatment of facial acne vulgaris: results of a randomized, controlled study. Br J Dermatol. 2006;155: 608–13.
Horfelt C, Stenquist B, Larko O, et al. Photodynamic therapy for acne vulgaris: a pilot study of the dose-response and mechanism of action. Acta Derm Venereol. 2007;87:325–9.
Mills OH, Porte M, Kligman AM. Enhancement of comedogenic substances by ultraviolet radiation. Br J Dermatol. 1978;98:145–50.
Papageorgiou P, Katsambas A, Chu A. Phototherapy with blue (415 nm) and red (660 nm) light in the treatment of acne vulgaris. Br J Dermatol. 2000;142:973–8.
Sadick NS. Handheld LED array device in the treatment of acne vulgaris. J Drugs Dermatol. 2008;7:347–50.
Horfelt C, Stenquist B, Halldin CB, et al. Single low-dose red light is as efficacious as methyl-aminolevulinate–photodynamic therapy for treatment of acne: clinical assessment and fluorescence monitoring. Acta Derm Venereol. 2009;89:372–8.
Skiveren J, Haedersdal M, Philipsen PA, et al. Morphine gel 0.3% does not relieve pain during topical photodynamic therapy: a randomized, double-blind, placebo-controlled study. Acta Derm Venereol. 2006;86:409–11.
Sandberg C, Stenquist B, Rosdahl I, et al. Important factors for pain during photodynamic therapy for actinic keratosis. Acta Derm Venereol. 2006;86: 404–8.
Holmes MV, Dawe RS, Ferguson J, et al. A randomized, double-blind, placebo-controlled study of the efficacy of tetracaine gel (Ametop) for pain relief during topical photodynamic therapy. Br J Dermatol. 2004;150:337–40.
Langan SM, Collins P. double-blind, placebo-controlled prospective study of the efficacy of topical anaesthesia with a eutetic mixture of lignocaine 2.5% and prilocaine 2.5% for topical 5-aminolaevulinic acid-photodynamic therapy for extensive scalp actinic keratoses. Br J Dermatol. 2006;154:146–9.
Grapengiesser S, Ericson M, Gudmundsson F, et al. Pain caused by photodynamic therapy of skin cancer. Clin Exp Dermatol. 2002;27:493–7.
Wiegell SR, Skiveren J, Philipsen PA, et al. Pain during photodynamic therapy is associated with protoporphyrin IX fluorescence and fluence rate. Br J Dermatol. 2008;158:727–33.
Borelli C, Herzinger T, Merk K, et al. Effect of subcutaneous infiltration anesthesia on pain in photodynamic therapy: a controlled open pilot trial. Dermatol Surg. 2007;33:314–8.
Paoli J, Halldin C, Ericson MB, et al. Nerve blocks provide effective pain relief during topical photodynamic therapy for extensive facial actinic keratoses. Clin Exp Dermatol. 2008;33:559–64.
Halldin CB, Paoli J, Sandberg C, et al. Nerve blocks enable adequate pain relief during topical photodynamic therapy of field cancerization on the forehead and scalp. Br J Dermatol. 2009;160:795–800.
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Sandberg, C., Wennberg, AM., Larkö, O. (2011). Photodynamic Therapy of Acne. In: Gold, M. (eds) Photodynamic Therapy in Dermatology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1298-5_9
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DOI: https://doi.org/10.1007/978-1-4419-1298-5_9
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