Photodynamic Therapy for the Treatment of Verrucae, Condylomata Acuminata, and Molluscum Contagiosum Lesions

Chapter

Abstract

The use of ALA-PDT has been shown to be successful for the treatment of recalcitrant verrucae, condylomata acuminata, and molluscum contagiosum lesions. Studies have shown that ALA-PDT is a useful modality for these lesions and that it should be considered when confronted with a patient with any of these viral conditions. Additional studies are warranted to further evaluate protocols used, light sources, and incubation times, to determine how to make the therapy even more appealing to clinicians and patients alike.

Keywords

Placebo Burning Dioxide Urea DMSO 

References

  1. 1.
    Jeffes EW, McCullough JL, Weinstein GD, Kaplan R, Glazer SD, Taylor JR. Photodynamic therapy of actinic keratoses with topical aminolevulinic acid hydrochloride and fluorescent blue light. J Am Acad Dermatol. 2001;45:96–104.PubMedCrossRefGoogle Scholar
  2. 2.
    Stender IM. Treatment of human papilloma virus. In: Goldman MP, editor. Photodynamic therapy. Munich: Elsevier; 2005. p. 77–88.Google Scholar
  3. 3.
    Bourke JF, Berth-Jones J, Hutchinson PE. Cryotherapy of common viral warts at intervals of 1, 2, and 3 weeks. Br J Dermatol. 1995;132:433–6.PubMedCrossRefGoogle Scholar
  4. 4.
    Logan RA, Zachary CB. Outcome of carbondioxide laser therapy for persistent cutaneous viral warts. Br J Dermatol. 1989;121:99.PubMedCrossRefGoogle Scholar
  5. 5.
    Tan OT, Hurwitz TM, Stafford TJ. Pulsed dye laser treatment of recalcitrant verrucae, a premliminary report. Lasers Surg Med. 1993;13:127–37.PubMedCrossRefGoogle Scholar
  6. 6.
    Hirose R, Hori M, Shukuwa R, Udono M, Yamada M, Koide T, et al. Topical treatment of resistant warts with glutaraldehyde. J Dermatol. 1994;21:248–53.PubMedGoogle Scholar
  7. 7.
    Bunney MH, Nolan MW, Williams DA. An assessment of methods of treating viral warts by comparative treatment trials based on standard design. Br J Dermatol. 1976;94:667–80.PubMedCrossRefGoogle Scholar
  8. 8.
    Halasz CL. Treatment of common warts using the infrared conagulator. J Dermatol Surg Oncol. 1994;20:252–6.PubMedGoogle Scholar
  9. 9.
    Brodell RT, Breadle DL. The treatment of palmar and plantar warts using natural alpha interferon and a needleless injector. Dermatol Surg. 1995;21:213–8.PubMedGoogle Scholar
  10. 10.
    James MP, Collier PM, Aherne W, Hardcastle A, Lovegrove S. Histologic, pharmacologic and immunocytochemical effects of injection of bleomycin. J Am Acad Dermatol. 1993;28:933–7.PubMedCrossRefGoogle Scholar
  11. 11.
    Shah KC, Patel RM, Umrigar DP. Dinitroclorobenzene treatment of verrucae plana. J Dermatol. 199118(11):639–42.Google Scholar
  12. 12.
    Schneede P. Genital human papillomarvirus infections. Curr Opin Urol. 2002;12:57–61.PubMedCrossRefGoogle Scholar
  13. 13.
    Siegfried EC. Warts and molluscum contagiosum on children: an approach to therapy. Dermatol Ther. 1997;2:51–67.Google Scholar
  14. 14.
    Verbov J. How to manage warts. Arch Der Child. 1999;80:97–9.CrossRefGoogle Scholar
  15. 15.
    Lewis EJ, Lam M, Crutchfield CE. An update on molluscum contagiosum. Cutis. 1997;60:29–34.PubMedGoogle Scholar
  16. 16.
    Husar K, Skerlev M. Molluscum contagiosum from infancy to maturity. Clin Dermatol. 2002;20:170–2.PubMedCrossRefGoogle Scholar
  17. 17.
    Coldiron BM, Bergstresser PR. Prevalence and clinical spectrum of skin disease in patients infected with human immunodeficiency virus. Arch Dermatol. 1989;125:357–61.PubMedCrossRefGoogle Scholar
  18. 18.
    Czelasta A, Yen-Moore A, Vander Straten M, Carrasco D, Tyring SK. An overview of sexually transmitted diseases. Part III. Sexually transmitted diseases in HIV-infected patients. J Am Acad Dermatol. 2000;43:409–32.CrossRefGoogle Scholar
  19. 19.
    Schwartz JJ, Myskowsk PL. Molluscum contagiosum in patients with humanimmunodeficiency virus infection: a review of twenty-seven patients. J Am Acad Dermatol. 1992;27:583–8.PubMedCrossRefGoogle Scholar
  20. 20.
    Lowy DR. Molluscum contagiosum. In: Freedberg IM, Eisen AZ, Wolff K, et al., editors. Dermatology in general medicine. New York: McGraw-Hill; 1999. p. 2478–81.Google Scholar
  21. 21.
    Matis WL, Triana A, Shapiro R, Eldred L, Polk BF, Hood AF. Dermatologic findings associated with human immunodeficiency virus infection. J Am Acad Dermatol. 1987;17(5 Pt 1):746–51.PubMedCrossRefGoogle Scholar
  22. 22.
    Goodman DS, Teplitz ED, Wishner A, Klein RS, Burk PG, Hershenbaum E. Prevalence of cutaneous disease in patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex. J Am Acad Dermatol. 1987;17(2 Pt 1):210–20.PubMedCrossRefGoogle Scholar
  23. 23.
    Schwartz JJ, Myskowski PL. Molluscum contagiosum in patients with human immunodeficiency virus infection. A review of twenty-seven patients. J Am Acad Dermatol. 1992;27(4):583–8.PubMedCrossRefGoogle Scholar
  24. 24.
    Epstein WL, Senecal I, Krasnobrod H. Viral antigens in human epidermal tumors: localization of an antigen to molluscum contagiosum. J Invest Dermatol. 1963;40:51.Google Scholar
  25. 25.
    Kwittken J. Molluscum contagiosum: some new histologic observations. Mt Sina J Med. 1980;47:583.Google Scholar
  26. 26.
    Ammann R, Hunziker T, Braathen LR. Topical photodynamic therapy in verrucae. Dermatology. 1995;191:346–7.PubMedCrossRefGoogle Scholar
  27. 27.
    Smetana Z, Malik Z, Orenstein A, et al. Treatment of viral infections with 5-aminolevulinic acid and light. Lasers Surg Med. 1997;21:351–8.PubMedCrossRefGoogle Scholar
  28. 28.
    Stender IM, Na R, Fogh H, et al. Photodynamic therapy with 5-aminolevulinic acid or placebo for recalcitrant foot and hand warts: randomized double-blind trial. Lancet. 2000;355:963–6.PubMedCrossRefGoogle Scholar
  29. 29.
    Fabbrocini G, Costanzo M, Riccardo A, et al. Photodynamic therapy with topical 5-aminolevulinic acid for the treatment of plantar warts. J Photochem Photobiol B. 2001;61(1–2):30–4.PubMedCrossRefGoogle Scholar
  30. 30.
    Stender IM, Lock-Andersen J, Wulf HC. Recalcitrant hand and foot warts successfully treated with photodynamic therapy with topical 5-aminolaevulinic acid: a pilot study. Clin Exp Dermatol. 1999;24(3):154–9.PubMedCrossRefGoogle Scholar
  31. 31.
    Mizuki D, Kaneko T, Hanada K. Successful treatment of topical photodynamic therapy using 5-aminolevulinic acid for plane warts. Br J Dermatol. 2003;149(5):1087–8.PubMedCrossRefGoogle Scholar
  32. 32.
    Smucler R, Jatsova E. Comparative study of aminolevulic acid photodynamic therapy plus pulsed dye laser versus pulsed dye laser alone in treatment of viral warts. Photomed Laser Surg. 2005;23(2):202–5.PubMedCrossRefGoogle Scholar
  33. 33.
    Gold MH, Pope A. Fractional resurfacing aiding photodynamic therapy of a recalcitrant plantar verruca – a case report & review of the literature. J Clin Aesthet Dermatol. 2008;1(1):30–3.PubMedGoogle Scholar
  34. 34.
    Stefanaki IM, Georgiou S, Themelis GC, et al. In vivo fluorescence kinetics and photodynamic therapy in condylomata acuminate. Br J Dermatol. 2003;149:972–6.PubMedCrossRefGoogle Scholar
  35. 35.
    Wang XL, Wang HW, Wang HS, et al. Topical 5-aminovaevulinic clylomata acuminate. Br J Dermatol. 2004;151:880–5.PubMedCrossRefGoogle Scholar
  36. 36.
    Chen K, Chang BZ, Ju M, et al. Comparative study of photodynamic therapy vs CO2 laser vaporization in treatment of condylomata acuminate, a randomized clinical trial. Br J Dermatol. 2007;156:516–20.PubMedCrossRefGoogle Scholar
  37. 37.
    Liang J, Lu XN, Tang H, et al. Evaluation of photodynamic therapy using topical aminolevulinic acid hydrochloride in the treatment of condylomata acuminata: a comparative, randomized clinical trial. Photodermatol Photoimmunol Photomed. 2009;25(6):293–7.PubMedCrossRefGoogle Scholar
  38. 38.
    Gold MH. The Use of ALA-PDT in the treatment of recalcitrant molluscum contagiosum in HIV/AIDS affected individuals. J Laser Surg Med. 2003;15(Suppl):40.Google Scholar
  39. 39.
    Moiin A, Gold MH. Treatment of verrucae vulgaris and molluscum contagiosum with photodynamic therapy. Dermatol Clin. 2007;25:75–80.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Gold Skin Care Center, Tennessee Clinical Research CenterNashvilleUSA
  2. 2.Department of DermatologyVanderbilt University School of Medicine and NursingNashvilleUSA

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