Inhibitory Control Deficits in Childhood: Definition, Measurement, and Clinical Risk for Substance Use Disorders

  • Iliyan Ivanov
  • Jeffrey Newcorn
  • Kelly Morton
  • Michelle Tricamo
Chapter

Abstract

This chapter examines how the behavioral trait of impulsivity, when present in childhood as feature of disruptive behavior disorders such as attention deficit/hyperactivity disorder (ADHD) and conduct disorder (CD), may contribute to the development of substance abuse disorders in adolescence. We discuss the relationship between the constructs of impulsivity and inhibitory control deficits and review their clinical manifestations in youth with ADHD and CD. We also review evidence suggesting that high levels of impulsivity in children can be viewed as a predictor of later substance abuse, and provide information about the possible biological underpinnings of such risk factors. The hypotheses that biological factors could potentially mediate the transition from drug experimentation to drug abuse and dependence is important for the development of prevention and treatment strategies to combat different types of addiction. Clinical considerations related to biological and psychological therapeutic interventions for impulsive types of behaviors in childhood and adolescence are also discussed.

References

  1. Achenbach, T.M. (1991). Manual for the child behavior checklist/4–18 and 1991. Profile. Burlington, VT: University of Vermont Department of Psychiatry.Google Scholar
  2. Anderson, A.L., Reid, M.S., Li, S.H., Holmes, T., Shemanski, L., Slee, A., Smith, E.V., Kahn, R., Chiang, N., Vocci, F., Ciraulo, D., Dackis, C., Roache, J.D., Salloum, I.M., Somoza, E., Urschel, H.C. & Elkashef, A. M. (2009). Modafinil for the treatment of cocaine dependence. Drug and Alcohol Dependence, 104(1–2), 133–9.PubMedCrossRefGoogle Scholar
  3. Aron, J. L. & Paulus, M.P. (2007). Location, location: Using functional magnetic resonance imaging to pinpoint brain differences relevant to stimulant use. Addiction,102 (Supplement 1), 33–43.Google Scholar
  4. Barkley, R. A., Fischer, M., Smallish, L., & Fletcher, K. (2003). Does the treatment of attention-deficit/hyperactivity disorder with stimulants contribute to drug use/abuse? A 13-year prospective study. Pediatrics, 111, 97–109.PubMedCrossRefGoogle Scholar
  5. Barkley, R.A., Fischer, M., Edelbrock, C.S., & Smallish, L. (1990). The adolescent outcome of hyperactive children diagnosed by research criteria: I. An 8-year prospective follow-up study. Journal of the American Academy of Child and Adolescent Psychiatry, 29, 546–557.Google Scholar
  6. Barratt, E.S. (1994). Impulsiveness and aggression. in Violence and mental disorder: developments in risk assessment, Monahan J and Steadman HJ (eds). Chicago, University of Chicago Press, 61–79.Google Scholar
  7. Barratt, E.S. (1959). Anxiety and impulsiveness related to psychomotor efficiency. Perceptual and Motor Skills, 9, 191–198.CrossRefGoogle Scholar
  8. Bechara, A.R., Damasio, H., Damasio & Anderson, S.W. (1994). Insensitivity to future consequences following damage to human prefrontal cortex, Cognition, 50 (1–3), 7–15PubMedCrossRefGoogle Scholar
  9. Biederman, J., Monuteaux, M.C., Spencer, T., Wilens, T.E., Macpherson, H.A., & Faraone, S.V. (2008). Stimulant therapy and risk for subsequent substance use disorders in male adults with ADHD: a naturalistic controlled 10-year follow-up study. American Journal of Psychiatry, 165, 597–603.PubMedCrossRefGoogle Scholar
  10. Biederman, J., Wilens, T., Mick, E., Spencer, T., & Faraone, S. V. (1999). Pharmacotherapy of attention-deficit/hyperactivity disorder reduces risk for substance use disorder. Pediatrics, 104, e20.PubMedCrossRefGoogle Scholar
  11. Bush, G. (2010). Attention-deficit/hyperactivity disorder and attention networks. Neuropsychopharmacology, 35(1), 278–300.PubMedCrossRefGoogle Scholar
  12. Buss, A.H. (1975) A temperament theory of personality development. New York: John Wiley.Google Scholar
  13. Cantwell, D.P., Lewinsohn, P.M., Rohde, P. & Seeley, J.R. (1997). Correspondence between adolescent report and parent report of psychiatric diagnostic data. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 610–619.PubMedCrossRefGoogle Scholar
  14. Carbonneau, R., Tremblay, R.E., Vitaro F., Dobkin, P.L., Saucier, J.F. & Pihl, R.O. (1998). Paternal alcoholism, paternal absence and the development of problem behaviors in boys from age six to twelve years. Journal of Studies on Alcohol and Drugs, 59(4), 387–98.Google Scholar
  15. Clark, L., Cools, R. & Robbins, T.W. (2004) The neuropsychology of ventral prefrontal cortex: decision-making and reversal learning. Brain Cognition 55, 41–53.CrossRefGoogle Scholar
  16. Cloninger, C.R., Przybeck, T.R., Svrakic, D.M. & Wetzel, R.D. (1994) The Temperament and Character Inventory (TCI): a guide to its development and use. Washington University, St Louis, Missouri: Center for psychobiology of personality.Google Scholar
  17. Conners, K. (2000). Conners’ Rating Scales-Revised Technical Manual. North Tonawanda, New York: Multi Health Systems.Google Scholar
  18. Crews, F., He, J. & Hodge, C. (2007). Adolescent cortical development: A critical period of vulnerability for addiction. Pharmacology Biochemistry and Behavior, 86(2), 189–199.CrossRefGoogle Scholar
  19. Dackis, C.A., Kampman, K. M., Lynch, K.G., Pettinati, H.M. & O’Brien, C.P. (2005). A double blind, placebo controlled trial of modafinil for cocaine dependence. Neuropyschopharmacology, (30), 205–211.CrossRefGoogle Scholar
  20. Daugherty, T.K. & Quay, H.C. (2006) Response perseveration and delayed responding in childhood behavior disorders. Journal of Child Psychology and Psychiatry. 32 (3), 453–461.CrossRefGoogle Scholar
  21. Davids, E. & Gastpar, M. (2003). Attention-deficit/hyperactivity disorder and substance abuse. Journal of Psychiatric Practice, 30(4), 182–6.Google Scholar
  22. Dennis, M., Godley, S.H., Diamond, G., Tims, F.M., Babor, T., Donaldson, J., Liddle, H., Titus, J.C., Kaminer, Y., Webb, C., Hamilton, N. & Funk, R. (2004). The Cannabis Youth Treatment (CYT) Study: Main findings from two randomized trials. Journal of Substance Abuse Treatment,27(3),197–213.Google Scholar
  23. DeWit, D.J., Adlaf, E.M., Offord, D.R. & Ogborne, A.C. (2000). Age at first alcohol use: A risk factor for the development of alcohol disorders. American Journal of Psychiatry, 157(5), 745–50.PubMedCrossRefGoogle Scholar
  24. Dickman, S.J. (1990). Functional and dysfunctional impulsivity: personality and cognitive correlates. Journal of Personality and Social Psychology, 58, 95–102.PubMedCrossRefGoogle Scholar
  25. Dom, G., De Wilde, B., Hulstijn, W., van den Brink, W. & Sabbe, B. (2006). Behavioural aspects of impulsivity in alcoholics with and without a cluster-B personality disorder. Alcohol and Alcoholism, 41(4), 412–20.PubMedCrossRefGoogle Scholar
  26. Dom, G., Sabbe, B., Hulstijn, W. & van den Brink, W. (2005). Substance use disorders and the orbitofrontal cortex: systematic review of behavioural decision-making and neuroimaging studies. British Journal of Psychiatry, 187, 209–20.PubMedCrossRefGoogle Scholar
  27. Duncan, J. & Owen, A.M. (2000). Common regions of the human frontal lobe recruited by diverse cognitive demands. Trends in Neuroscience, 23(10), 475–83.CrossRefGoogle Scholar
  28. Eriksen, B.A. & Eriksen, C.W. (1974) Effects of noise letters upon the identification of a target letter in a nonsearch task, Perception & Psychophysics 16, 143–149.CrossRefGoogle Scholar
  29. Eysenck, S.B.G. & Eysenck, E.H. (1977). The place of impulsiveness in a dimensional system of personality description. British Journal of Social Clinical Psychology, 16(1), 57–68.Google Scholar
  30. Evenden, J.L. (1999) Varieties of impulsivity. Psychopharmacology. 146(4), 348–61.PubMedCrossRefGoogle Scholar
  31. Everitt, B.J. & Wolf, M.E. (2002). Psychomotor stimulant addiction: a neural systems perspective. The Journal of Neuroscience, 22(9), 3312–3320.PubMedGoogle Scholar
  32. Garavan, H. & Hester, R. (2007). The role of cognitive control in cocaine dependence. Neuropsychological Review, 17(3), 337–45.CrossRefGoogle Scholar
  33. Grabowski, J., Rhoades, H., Schmitz, J., Stotts, A., Daruzska, L.A., Creson, D. & Moeller, F.G. (2001). Dextroamphetamine for cocaine-dependence treatment: a double-blind randomized clinical trial. Journal of Clinical Psychopharmacology, 21(5), 522–6.PubMedCrossRefGoogle Scholar
  34. Grant, B.F. & Dawson, D.A. (1998). Age of onset of drug use and its association with DSM-IV drug abuse and dependence: Results from the National Longitudinal Alcohol Epidemiologic Survey. Journal of Substance Abuse, 10(2), 163–73.PubMedCrossRefGoogle Scholar
  35. Goldstein, R.Z., Craig, A.D., Bechara, A., Garavan, H., Childress, A.R., Paulus, M.P., & Volkow, N.D. (2009). The neurocircuitry of impaired insight in drug addiction. Trends in Cognitive Science, 13(9), 372–80.CrossRefGoogle Scholar
  36. Gordon, S.M., Tulak, F. & Troncale, J. (2004). Prevalence and characteristics of adolescent patients with co-occurring ADHD and substance dependence. Journal of Addiction Diseases, 23, 31–40.CrossRefGoogle Scholar
  37. Halperin, J.M., Newcorn, J.H., Matier, K., Bedi, G., Hall, S. & Sharma, V. (1995). Impulsivity and the initiation of fights in children with disruptive behavior disorders. Journal of Child Psycholology and Psychiatry, 36(7), 1199–211.CrossRefGoogle Scholar
  38. Heil, S.H., Holmes, H.W., Bickel, W.K., Higgins, S.T., Badger, G.J., Laws, H.F. Comparison of the subjective, physiological, and psychomotor effects of atomoxetine and methylphenidate in light drug users. Dr Alcohol Dependence 2002;67(2):149–56.CrossRefGoogle Scholar
  39. Jasinski, D.R., Krishnan, S. Abuse liability and safety of oral lisdexamfetamine dimesylate in individuals with a history of stimulant abuse. J Psychopharmacol. 2009 Jun;23(4):419–27.CrossRefGoogle Scholar
  40. Jentsch, J.D. & Taylor, J.R. (1999). Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli. Psychopharmacology, 146(4), 373–390.PubMedCrossRefGoogle Scholar
  41. Kaiser, N.M., Hoza, B. & Hurt, E.A. (2008). Multimodal treatment for childhood attention- deficit/hyperactivity disorder. Expert Review of Neuropathy, 8(10), 1573–1583.CrossRefGoogle Scholar
  42. Lambert, N.M. & Hartsough, C.S. (1998). Prospective study of tobacco smoking and substance dependencies among samples of ADHD and non-ADHD participants. Journal of Learning Disabilties, 31(6), 533–44.CrossRefGoogle Scholar
  43. Ledgerwood, D.M. (2008). Contingency management for smoking cessation: Where do we go from here? Current Drug Abuse Review, 1(3), 340–349.CrossRefGoogle Scholar
  44. Lejuez, C.W., Read, J.P., Kahler, C.W., Richards, J.B., Ramsey, S.E., Stuart, G.L., Strong, D.R. & Brown, R.A. (2002) Evaluation of a behavioral measure of risk taking: The Balloon Analogue Risk Task (BART). Journal of Experimental Psychology: Applied, 8, 75–84.PubMedCrossRefGoogle Scholar
  45. Logan, G.D., Cowan, W.B. & Davis, K.A. (1984) On the ability to inhibit simple and choice reaction time responses: a model and a method. Journal of Experimental Psychology: Human Perception and Performance 10, 276–29.PubMedCrossRefGoogle Scholar
  46. Lynskey, M.T. & Fergusson, D.M. (1995) Childhood conduct problems, attention deficit behaviors, and adolescent alcohol, tobacco, and illicit drug use. Journal of Abnormal Child Psychology, 23, 281–302.PubMedCrossRefGoogle Scholar
  47. MacLeod, C.M. (1991). Half a century of research on the Stroop effect: An integrative review. Psychogy Bulletin. 109, 163–203.CrossRefGoogle Scholar
  48. Mannuzza, S., Klein, R.G., Truong, N.L., Moulton, J.L., III, Roizen, E.R., Howell, K.H., Castellanos, F.X. (2008). Age of methylphenidate treatment initiation in children with ADHD and later substance abuse: Prospective follow-up into adulthood. American Journal of Psychiatry, 165, 604–609.PubMedCrossRefGoogle Scholar
  49. Martel, M.M., Pierce, L., Nigg, J.T., Jester, J.M., Adams, K., Puttler, L.I., Buu, A., Fitzgerald, H. & Zucker, R.A. (2009). Temperament pathways to childhood disruptive behavior and adolescent substance abuse: testing a cascade model. Journal of Abnormal Child Psychology. 37(3), 363–73.PubMedCrossRefGoogle Scholar
  50. Moeller, F.G., Barratt, E.S., Dougherty, D.M., Schmitz, J.M. & Swann, A.C. (2001) Psychiatric aspects of impulsivity. American Journal of Psychiatry, 158(11), 1783–93.PubMedCrossRefGoogle Scholar
  51. Moeller F.G., Schmitz J.M., Herin D., Kjome K.L. (2008) Use of stimulants to treat cocaine and methamphetamine abuse. Current Psychiatry Review, 10(5), 385–91.CrossRefGoogle Scholar
  52. Molina, B.S.G., Flory, K., Hinshaw, S.P., Greiner, A.R., Arnold, L.E., Swanson, J.M. Wigal, T. (2007). Delinquent behavior and emerging substance use in the MTA at 36 months: prevalence, course, and treatment effects. Journal of the American Academy of Child and Adolescent Psychiatry, 46, 1027–1039.CrossRefGoogle Scholar
  53. Molina, B.S. & Pelham, Jr., W.E. (2003). Childhood predictors of adolescent substance use in a longitudinal study of children with ADHD. Journal of Abnormal Psychology, 112(3), 497–507.PubMedCrossRefGoogle Scholar
  54. Mooney, M.E., Herin, D.V., Schmitz, J.M., Moukaddam, N., Green, C.E. & Grabowski, J. (2009). Effects of oral methamphetamine on cocaine use: a randomized, double-blind, placebo-controlled trial. Drug and Alcohol Dependence, 101(1–2), 34–41.PubMedCrossRefGoogle Scholar
  55. Moss, H.B. & Lynch, K.G. (2001). Comorbid disruptive behavior disorder symptoms and their relationship to adolescent alcohol use disorders. Drug and Alcohol Dependence, 64(1), 75–83.PubMedCrossRefGoogle Scholar
  56. Norwalk, K., Norvilitis, J.M., MacLean, M.G. ADHD symptomatology and its relationship to factors associated with college adjustment. J Atten Disord. 2009 Nov;13(3):251–8.CrossRefGoogle Scholar
  57. Patton, J.M., Stanford, M.S. & Barratt, E.S. (1995). Factor Structure of the Barratt Impulsiveness Scale. Journal of Clinical Psychology, 51, 768–774.PubMedCrossRefGoogle Scholar
  58. Perry, J.L. & Carroll, M.E. (2008) The role of impulsive behaviors in drug abuse. Psychopharmacology, 200(1):1–26.PubMedCrossRefGoogle Scholar
  59. Ramirez, A., Ekselius, L. & Ramklint, M. Mental disorders among young adults self-referred and referred by professionals to specialty mental health care. Psychiatr Serv. 2009 Dec;60(12):1649–55CrossRefGoogle Scholar
  60. Rangaswamy, M., Porjesz, B., Ardekani, B.A., Choi, S.J., Tanabe, J.L., Lim, K.O., & Begleiter, H. A functional MRI study of visual oddball: evidence for frontoparietal dysfunction in subjects at risk for alcoholism. Neuroimage, 2004. 21(1): p. 329–39.PubMedCrossRefGoogle Scholar
  61. Rhode, P., Kahler, C. W., Lewinsohn, P. M. & Brown, R. A. (2004). Psychiatric disorders, familial factors, and cigarette smoking: Associations with progression to daily smoking. Nicotine and Tobacco Research, 6(1), 119–132.CrossRefGoogle Scholar
  62. Robinson, T.E. & Kolb, B. (1997). Persistent structural modifications in nucleus accumbens and prefrontal cortex neurons produced by previous experience with amphetamine. Journal of Neuroscience, 17, 8491–8497.PubMedGoogle Scholar
  63. Rogers, R.D., Everitt, B.J., Baldacchino, A., Blackshaw, A.J., Swainson, R., Wynne, K., Baker, N.B., Hunter, J., Carthy, T., Booker, E., London, M., Deakin, J.F., Sahakian, B.J. & Robbins, T.W. (1999) Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: evidence for monoaminergic mechanisms, Neuropsychopharmacology, 20, 322–339.PubMedCrossRefGoogle Scholar
  64. Schweinsburg, A.D., Paulus, M.P., Barlett, V.C., Killeen, L.A., Caldwell, L.C., Pulido, C., Brown, S.A. & Tapert, S.F. An FMRI study of response inhibition in youths with a family history of alcoholism. Ann N Y Acad Sci, 2004. 1021: p. 391–4.PubMedCrossRefGoogle Scholar
  65. Shrier, L.A., Harris, S.K., Kurland, M. & Knight, J.R. (2003). Substance use problems and associated psychiatric symptoms among adolescents in primary care. Pediatrics, 111, e699–e705.PubMedCrossRefGoogle Scholar
  66. Shaw, P., Lalonde, F., Lepage, C., Rabin, C., Eckstrand, K., Sharp, W., Greenstein, D., Evans, A., Giedd, J.N. & Rapoport, J. Development of cortical asymmetry in typically developing children and its disruption in attention-deficit/hyperactivity disorder. Arch Gen Psychiatry. 2009 Aug;66(8):888–96. CrossRefGoogle Scholar
  67. Spear, L.P., The adolescent brain and age-related behavioral manifestations. Neurosci Biobehav Rev, 2000. 24(4): p. 417–63.PubMedCrossRefGoogle Scholar
  68. Smith, B.H., Pelham, W.E., Jr., Gnagy, E., Molina, B. & Evans, S. (2001) The reliability, validity, and unique contributions of self-report by adolescents receiving treatment for attention-deficit/hyperactivity disorder. Journal of Consult and Clinical Psychology. 68(3):489–99CrossRefGoogle Scholar
  69. Sonuga-Barke, E. J. (2003). The dual pathway model of AD/HD: an elaboration of neuro- developmental characteristics. Neuroscience Biobehavior Review, 27(7), 593–604.CrossRefGoogle Scholar
  70. Spencer, T.J., Biederman, J. & Mick, E. Attention-deficit/hyperactivity disorder: diagnosis, lifespan, comorbidities, and neurobiology. Ambul Pediatr. 2007 Jan-Feb;7(1 Suppl):73–81.Google Scholar
  71. Tarter, R.E., Kirisci L., Mezzich, A., Cornelius, J.R., Pajer, K., Vanyukov, M., Gardner, W., Blackson T., & Clark, D. (2003). Neurobehavioral disinhibition in childhood predicts early age at onset of substance use disorder. American Journal of Psychiatry, 160(6), 1078–85.PubMedCrossRefGoogle Scholar
  72. Tarter, R., Vanyukov, M., Giancola, P., Dawes, M., Blackson, T., Mezzich, A. & Clark, D.B. (1999). Etiology of early age onset substance use disorder: a maturational perspective. Developmental Psychopathology, 11(4), 657–83.CrossRefGoogle Scholar
  73. Thompson, L.L., Riggs, P.D., Mikulich, S.K. & Crowley, T.J. (1996). Contribution of ADHD symptoms to substance problems and delinquency in conduct-disordered adolescents. Journal of Abnormal Child Psychology, 24(3), 325–47.PubMedCrossRefGoogle Scholar
  74. Vocci, F.J. & Montoya, I.D. (2009) Psychological treatments for stimulant misuse, comparing and contrasting those for amphetamine dependence and those for cocaine dependence. Current Opinion in Psychiatry. 22(3), 263–8PubMedCrossRefGoogle Scholar
  75. Wigal, S.B. (2009). Efficacy and safety limitations of attention-deficit hyperactivity disorder pharmacotherapy in children and adults. CNS Drugs, 23(Supplement 1), 21–31.Google Scholar
  76. Winstanley, C.A., Eagle, D.M. & Robbins, T.W. (2006). Behavioral models of impulsivity in relation to ADHD: translation between clinical and preclinical studies. Clinical Psychology Review, 26(4), 379–95.PubMedCrossRefGoogle Scholar
  77. Zuckerman, M., Kolin, E.A., Price, L. & Zoob, I. (1964). Development of a Sensation seeking scale, Journal of Consulting Psychology. 28(6), 477–482.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Iliyan Ivanov
    • 1
  • Jeffrey Newcorn
  • Kelly Morton
  • Michelle Tricamo
  1. 1.Mount Sinai School of MedicineNew YorkUSA

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