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Circadian Clocks and Metabolism

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The Circadian Clock

Part of the book series: Protein Reviews ((PRON,volume 12))

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Abstract

The processes that underlie circadian timekeeping and the regulation of metabolic homeostasis are tightly and reciprocally linked. It is no surprise that many aspects of modern lifestyle such as sleep curtailment, shift work and artificial lighting simultaneously affect the clock and metabolic control. Deregulation of central and peripheral clocks affects metabolic state via processes such as glucose homeostasis or lipid processing while metabolic dysfunction impacts on circadian rhythmicity at both physiological and molecular levels. This chapter summarises the current knowledge of the processes underlying these phenomena, drawing from epidemiological, clinical, animal and molecular studies. It delineates major open problems and outlines some possible approaches towards an application of chronobiological science for the clinics and society.

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Acknowledgements

I would like to thank Dr. Judit Kovac for helpful comments on the manuscript. H.O.’s work is supported by an Emmy Noether fellowship of the Deutsche Forschungsgemeinschaft.

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  1. Circadian Rhythms Group, Max Planck Institute for Biophysical Chemistry, 37077, Göttingen, Germany

    Henrik Oster

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Correspondence to Henrik Oster .

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  1. Inst. Biochimie, Université de Fribourg, rue du Musee 5, Fribourg, 1700, Switzerland

    Urs Albrecht

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Oster, H. (2010). Circadian Clocks and Metabolism. In: Albrecht, U. (eds) The Circadian Clock. Protein Reviews, vol 12. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1262-6_5

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