Endoscopic Ablation of Barrett’s Esophagus and Early Esophageal Cancer

  • Virginia R. Litle
  • Thomas J. Watson
  • Jeffrey H. Peters
Chapter

Abstract

Barrett’s esophagus develops as a result of chronic, pathologic reflux of gastro-duodenal contents into the esophagus. The diagnosis is made upon the endoscopic finding of columnar lined epithelium in the distal esophagus associated with specialized intestinal metaplasia (IM) on histology [1, 2]. Barrett’s esophagus is classified as non-dysplastic IM, low-grade dysplasia (LGD), or high-grade dysplasia (HGD). Population-based studies suggest that Barrett’s esophagus is present in 1–2% of the US adult population [3] and is increasing in prevalence [4]. Screening upper endoscopy in patients undergoing colonoscopy has shown a remarkably high prevalence, varying from 7% to as much as 25% depending upon the population screened. In a general population of patients undergoing colonoscopy, Rex et al. reported that 6.8% were found to have esophageal intestinal metaplasia [5].

Keywords

Barrett’s esophagus Intestinal metaplasia Argon plasma coagulation cryotherapy Endoscopic mucosal resection Multipolar electrocoagulation Photodynamic therapy Radiofrequency ablation Dysplasia 

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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Virginia R. Litle
    • 1
  • Thomas J. Watson
    • 2
  • Jeffrey H. Peters
    • 3
  1. 1.Department of SurgeryUniversity of Rochester School of Medicine and DentistryRochesterUSA
  2. 2.Division of Thoracic and Foregut Surgery, Department of SurgeryUniversity of Rochester Medical CenterRochesterUSA
  3. 3.Department of SurgeryStrong Memorial Hospital, University of RochesterRochesterUSA

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