Honoring Dr. Elisabeth Bock

  • Vladimir BerezinEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 663)


I first met Elisabeth in October 1980 when I came to the Protein Laboratory and spent 9 months working under her supervision as a guest researcher. It was an exciting time where I was introduced to the most powerful tools of protein purification and identification at the time and also to NCAM-related research. I returned to the laboratory in 1993, and since then Elisabeth and I have been working in close collaboration on determining the structure and function of the NCAM molecule.


  1. 1.
    Jørgensen OS, Bock E (1974) Brain specific synaptosomal membrane proteins demonstrated by crossed immunoelectrophoresis. J Neurochem 23:879-880PubMedCrossRefGoogle Scholar
  2. 2.
    Bock E, Dissing J (1975) Demonstration of enolase activity connected to the brain specific protein 14-3-2. Scand J Immunol 4:31-36CrossRefGoogle Scholar
  3. 3.
    Bock E, Jørgensen OS (1975) Rat brain synaptic vesicles and plasma membranes compared by crossed immunoelectro-phoresis. FEBS Lett 52:37-39PubMedCrossRefGoogle Scholar
  4. 4.
    Gaardsvoll H, Obendorf D, Winkler H, Bock E (1988) Demonstration of immunochemical identity between the synaptic vesicle proteins synaptin and synaptophysin/p38. FEBS Lett 242:117-120PubMedCrossRefGoogle Scholar
  5. 5.
    Jensen PH, Soroka V, Thomsen NK, Berezin V, Bock E, Fl P (1999) Structure and interactions of NCAM modules 1 and 2 - basic elements in neural cell adhesion. Nature Struct Biol 6:486-493PubMedCrossRefGoogle Scholar
  6. 6.
    Kasper C, Rasmussen H, Kastrup JS, Ikemizu S, Jones EY, Berezin V, Bock E, Kjøller Larsen I (2000) Structural basis of cell-cell adhesion by NCAM. Nature Struct Biol 7:389-393PubMedCrossRefGoogle Scholar
  7. 7.
    Soroka V, Kolkova K, Kastrup J, Diederichs K, Breed J, Kiselyov V, Fl P, Larsen IK, Welte W, Berezin V, Bock E, Kasper C (2003) Structure and interactions of NCAM Ig1-2-3 suggest a novel zipper mechanism for homophilic adhesion. Structure 10:1291-1301CrossRefGoogle Scholar
  8. 8.
    Thomsen NK, Soroka V, Jensen PH, Berezin V, Kiselyov VV, Bock E, Poulsen FM (1996) The three-dimensional structure of the first domain of neural cell adhesion molecule. Nat Struct Biol 3:581-585PubMedCrossRefGoogle Scholar
  9. 9.
    Ditlevsen D, Køhler L, Berezin V, Bock E (2007) Cyclic GMP signalling pathway plays a role in NCAM-mediated neurite outgrowth and survival. J Neurosci Res 85:703-711PubMedCrossRefGoogle Scholar
  10. 10.
    Kolkova K, Stensmann H, Berezin V, Bock E, Larsson C (2005) Distinct roles of PKC isoforms in NCAM-mediated neurite outgrowth. J.Neurochem 92:886-894PubMedCrossRefGoogle Scholar
  11. 11.
    Kolkova K, Novitskaya V, Pedersen N, Berezin V, Bock E (2000) NCAM-stimulated neurite outgrowth depends on activation of protein kinase C and the Ras-Mitogen activated protein kinase pathway. J Neurosci 20:2238-2246PubMedGoogle Scholar
  12. 12.
    Rønn LCB, Olsen M, Østergaard S, Kiselyov V, Berezin V, Mortensen MT, Lerche MH, Jensen PH, Soroka V, Saffell JL, Doherty P, FlM P, Bock E, Holm A (1999) Identification of a neuritogenic ligand of the first Ig module of NCAM by means of a combinatorial library of synthetic peptides. Nat Biotechnol 17:1000-1005PubMedCrossRefGoogle Scholar
  13. 13.
    Kiselyov V, Soroka V, Berezin V, Bock E (2005) Structural biology of NCAM homophilic binding and activation of FGFR. J Neurochem 94:1169-1179PubMedCrossRefGoogle Scholar
  14. 14.
    Kiselyov VV, Skladchikova G, Hinsby A, Jensen PH, Kulahin N, Soroka V, Pedersen N, Tsetlin V, Berezin V, Poulsen FM, Berezin V, Bock E (2003) Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP. Structure (Camb) 11:691-701CrossRefGoogle Scholar
  15. 15.
    Cambon K, Hansen SM, Venero C, Herrero I, Skibo G, Berezin V, Bock E, Sandi C (2004) A synthetic NCAM mimetic peptide promotes synaptogenesis, enhances presynaptic function and facilitates memory consolidation J. Neuroscience 24:4197-4204PubMedCrossRefGoogle Scholar
  16. 16.
    Klementiev B, Novikova T, Novitskaya V, Walmod PS, Dmytriyeva Pakkenberg B, Berezin V, Bock E (2007) An NCAM-derived peptide reduces neuropathological signs and cognitive impairment induced by Aβ 25-35. Neuroscience 145:209-224PubMedCrossRefGoogle Scholar
  17. 17.
    Klementiev B, Novikova T, Korshunova I, Berezin V, Bock E (2008) The NCAM-derived P2 peptide facilitates recovery of cognitive and motor function and ameliorates neuropathology following traumatic brain injury. Eur J Neurosci 27:2885-2896PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Protein Laboratory, Department of Neuroscience and PharmacologyUniversity of CopenhagenCopenhagen NDenmark

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