Abstract
I first met Elisabeth in October 1980 when I came to the Protein Laboratory and spent 9 months working under her supervision as a guest researcher. It was an exciting time where I was introduced to the most powerful tools of protein purification and identification at the time and also to NCAM-related research. I returned to the laboratory in 1993, and since then Elisabeth and I have been working in close collaboration on determining the structure and function of the NCAM molecule.
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References
Jørgensen OS, Bock E (1974) Brain specific synaptosomal membrane proteins demonstrated by crossed immunoelectrophoresis. J Neurochem 23:879-880
Bock E, Dissing J (1975) Demonstration of enolase activity connected to the brain specific protein 14-3-2. Scand J Immunol 4:31-36
Bock E, Jørgensen OS (1975) Rat brain synaptic vesicles and plasma membranes compared by crossed immunoelectro-phoresis. FEBS Lett 52:37-39
Gaardsvoll H, Obendorf D, Winkler H, Bock E (1988) Demonstration of immunochemical identity between the synaptic vesicle proteins synaptin and synaptophysin/p38. FEBS Lett 242:117-120
Jensen PH, Soroka V, Thomsen NK, Berezin V, Bock E, Fl P (1999) Structure and interactions of NCAM modules 1 and 2 - basic elements in neural cell adhesion. Nature Struct Biol 6:486-493
Kasper C, Rasmussen H, Kastrup JS, Ikemizu S, Jones EY, Berezin V, Bock E, Kjøller Larsen I (2000) Structural basis of cell-cell adhesion by NCAM. Nature Struct Biol 7:389-393
Soroka V, Kolkova K, Kastrup J, Diederichs K, Breed J, Kiselyov V, Fl P, Larsen IK, Welte W, Berezin V, Bock E, Kasper C (2003) Structure and interactions of NCAM Ig1-2-3 suggest a novel zipper mechanism for homophilic adhesion. Structure 10:1291-1301
Thomsen NK, Soroka V, Jensen PH, Berezin V, Kiselyov VV, Bock E, Poulsen FM (1996) The three-dimensional structure of the first domain of neural cell adhesion molecule. Nat Struct Biol 3:581-585
Ditlevsen D, Køhler L, Berezin V, Bock E (2007) Cyclic GMP signalling pathway plays a role in NCAM-mediated neurite outgrowth and survival. J Neurosci Res 85:703-711
Kolkova K, Stensmann H, Berezin V, Bock E, Larsson C (2005) Distinct roles of PKC isoforms in NCAM-mediated neurite outgrowth. J.Neurochem 92:886-894
Kolkova K, Novitskaya V, Pedersen N, Berezin V, Bock E (2000) NCAM-stimulated neurite outgrowth depends on activation of protein kinase C and the Ras-Mitogen activated protein kinase pathway. J Neurosci 20:2238-2246
Rønn LCB, Olsen M, Østergaard S, Kiselyov V, Berezin V, Mortensen MT, Lerche MH, Jensen PH, Soroka V, Saffell JL, Doherty P, FlM P, Bock E, Holm A (1999) Identification of a neuritogenic ligand of the first Ig module of NCAM by means of a combinatorial library of synthetic peptides. Nat Biotechnol 17:1000-1005
Kiselyov V, Soroka V, Berezin V, Bock E (2005) Structural biology of NCAM homophilic binding and activation of FGFR. J Neurochem 94:1169-1179
Kiselyov VV, Skladchikova G, Hinsby A, Jensen PH, Kulahin N, Soroka V, Pedersen N, Tsetlin V, Berezin V, Poulsen FM, Berezin V, Bock E (2003) Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP. Structure (Camb) 11:691-701
Cambon K, Hansen SM, Venero C, Herrero I, Skibo G, Berezin V, Bock E, Sandi C (2004) A synthetic NCAM mimetic peptide promotes synaptogenesis, enhances presynaptic function and facilitates memory consolidation J. Neuroscience 24:4197-4204
Klementiev B, Novikova T, Novitskaya V, Walmod PS, Dmytriyeva Pakkenberg B, Berezin V, Bock E (2007) An NCAM-derived peptide reduces neuropathological signs and cognitive impairment induced by Aβ 25-35. Neuroscience 145:209-224
Klementiev B, Novikova T, Korshunova I, Berezin V, Bock E (2008) The NCAM-derived P2 peptide facilitates recovery of cognitive and motor function and ameliorates neuropathology following traumatic brain injury. Eur J Neurosci 27:2885-2896
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Berezin, V. (2010). Honoring Dr. Elisabeth Bock. In: Berezin, V. (eds) Structure and Function of the Neural Cell Adhesion Molecule NCAM. Advances in Experimental Medicine and Biology, vol 663. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1170-4_26
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